MLST typing of Escherichia coli isolates overproducing AmpC {beta}-lactamase.

A. Guillouzouic , N. Caroff , S. Dauvergne , D. Lepelletier , Agnès Perrin-Guyomard (1) , I. Kempf (2) , A. Reynaud , S. Corvec

1 Laboratoire d'études et de recherches sur les médicaments vétérinaires et les désinfectants
2 Laboratoire d'études et de recherches avicoles, porcines et piscicoles

Escherichia coli is the major commensal aerobic bacterium of the digestive tract of humans and animals, but is also the most frequent human bacterial pathogen. As a consequence, resistance mechanisms carried by this species are of particular concern. One of these mechanisms is the overproduction of the chromosomal AmpC β-lactamase, leading to increased MICs of most β-lactams including third-generation cephalosporins. AmpC overproduction is caused by various mutations in the ampC promoter (–42, –32 and –11) increasing homology with the consensus promoter for RNA polymerase,

Domains: Microbiology and Parasitology

A. Guillouzouic, N. Caroff, S. Dauvergne, D. Lepelletier, Agnès Perrin-Guyomard, et al.. MLST typing of Escherichia coli isolates overproducing AmpC {beta}-lactamase.. Journal of Antimicrobial Chemotherapy, 2009, 63 (6), pp.1290-2. ⟨10.1093/jac/dkp099⟩. ⟨hal-00405448⟩