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Journal Articles Journal of Antimicrobial Chemotherapy Year : 2009

MLST typing of Escherichia coli isolates overproducing AmpC {beta}-lactamase.

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Abstract

Escherichia coli is the major commensal aerobic bacterium of the digestive tract of humans and animals, but is also the most frequent human bacterial pathogen. As a consequence, resistance mechanisms carried by this species are of particular concern. One of these mechanisms is the overproduction of the chromosomal AmpC β-lactamase, leading to increased MICs of most β-lactams including third-generation cephalosporins. AmpC overproduction is caused by various mutations in the ampC promoter (–42, –32 and –11) increasing homology with the consensus promoter for RNA polymerase,

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hal-00405448 , version 1 (20-07-2009)

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A. Guillouzouic, N. Caroff, S. Dauvergne, D. Lepelletier, Agnès Perrin-Guyomard, et al.. MLST typing of Escherichia coli isolates overproducing AmpC {beta}-lactamase.. Journal of Antimicrobial Chemotherapy, 2009, 63 (6), pp.1290-2. ⟨10.1093/jac/dkp099⟩. ⟨hal-00405448⟩

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