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MLST typing of Escherichia coli isolates overproducing AmpC {beta}-lactamase.

Abstract : Escherichia coli is the major commensal aerobic bacterium of the digestive tract of humans and animals, but is also the most frequent human bacterial pathogen. As a consequence, resistance mechanisms carried by this species are of particular concern. One of these mechanisms is the overproduction of the chromosomal AmpC β-lactamase, leading to increased MICs of most β-lactams including third-generation cephalosporins. AmpC overproduction is caused by various mutations in the ampC promoter (–42, –32 and –11) increasing homology with the consensus promoter for RNA polymerase,
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Submitted on : Monday, July 20, 2009 - 3:01:49 PM
Last modification on : Tuesday, October 23, 2018 - 9:54:02 PM

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A. Guillouzouic, N. Caroff, S. Dauvergne, D. Lepelletier, Agnès Perrin-Guyomard, et al.. MLST typing of Escherichia coli isolates overproducing AmpC {beta}-lactamase.. Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2009, 63 (6), pp.1290-2. ⟨10.1093/jac/dkp099⟩. ⟨hal-00405448⟩



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