Spread of blaCTX-M-15-Producing Enterobacteriaceae and OXA-23-Producing Acinetobacter baumannii Sequence Type 2 in Tunisian Seafood

Yosra Mani (1) , Wejdene Mansour (1, 2) , Agnese Lupo (3) , Estelle Saras (3) , Olfa Bouallègue (1, 4) , Jean-Yves Madec (3) , Marisa Haenni (3)

1 CHU Sahloul - Hôpital Universitaire Sahloul
2 Institut Supérieur des Sciences Appliquées et de Technologie de Mahdia
3 AVB - Unité Antibiorésistance et Virulence Bactériennes
4 Université de Sousse

Bivalves are filter-feeding animals and markers of bacterial pollution. We report a massive spread of blaCTX-M-15 through dominant Escherichia coli and Klebsiella pneumoniae lineages and/or plasmid subtypes (F31:A4:B1) as well as the presence of OXA-23-producing Acinetobacter baumannii sequence type 2 (ST2) in seafood, highlighting a direct risk for the consumer. These findings should urge authorities to consider hospital effluents, and also farm and urban effluents, as important sources of extended-spectrum-beta-lactamase (ESBL)/carbapenemase producers that filter-feeding animals can concentrate and further spread to humans.

Keywords: seafood; seafood; ESBL; carbapenemase; E. coli; Acinetobacter; OXA-23; CTX-M-15; IncF; plasmid

Domains: Life Sciences [q-bio]; Microbiology and Parasitology; Bacteriology

Yosra Mani, Wejdene Mansour, Agnese Lupo, Estelle Saras, Olfa Bouallègue, et al.. Spread of blaCTX-M-15-Producing Enterobacteriaceae and OXA-23-Producing Acinetobacter baumannii Sequence Type 2 in Tunisian Seafood. Antimicrobial Agents and Chemotherapy, 2018, 62 (9), pp.e00727-18. ⟨10.1128/AAC.00727-18.⟩. ⟨anses-04018163⟩