Skip to Main content Skip to Navigation
Journal articles

A retrospective and regional approach assessing the genomic diversity of Salmonella Dublin

Abstract : From a historically rare serotype, Salmonella enterica subsp. enterica Dublin slowly became one of the most prevalent Salmonella in cattle and raw milk cheese in some regions of France. We present a retrospective genomic analysis of 480 S. Dublin isolates to address the context, evolutionary dynamics, local diversity and the genesis processes of regional S. Dublin outbreaks events between 2015 and 2017. Samples were clustered and assessed for correlation against metadata including isolation date, isolation matrices, geographical origin and epidemiological hypotheses. Significant findings can be drawn from this work. We found that the geographical distance was a major factor explaining genetic groups in the early stages of the cheese production processes (animals, farms) while down-the-line transformation steps were more likely to host genomic diversity. This supports the hypothesis of a generalised local persistence of strains from animal to finished products, with occasional migration. We also observed that the bacterial surveillance is representative of diversity, while targeted investigations without genomics evidence often included unrelated isolates. Combining both approaches in phylogeography methods allows a better representation of the dynamics, of outbreaks.
Complete list of metadata
Contributor : Christine Druesne Connect in order to contact the contributor
Submitted on : Friday, September 2, 2022 - 3:40:19 PM
Last modification on : Friday, September 30, 2022 - 4:04:13 AM


Publication funded by an institution


Distributed under a Creative Commons Attribution 4.0 International License



Madeleine de Sousa Violante, Gaëtan Podeur, Valérie Michel, Laurent Guillier, Nicolas Radomski, et al.. A retrospective and regional approach assessing the genomic diversity of Salmonella Dublin. NAR Genomics and Bioinformatics, Oxford University Press, 2022, 4 (3), pp.lqac047. ⟨10.1093/nargab/lqac047⟩. ⟨anses-03767215⟩



Record views


Files downloads