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Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks

Sebastian Hoffmann 1 Elisa Aiassa 2 Michelle Angrish 3 Claire Beausoleil 4 Frederic Bois 5 Laura Ciccolallo 2 Peter Craig 6 Rob de Vries 1 Jean Lou C M Dorne 2 Ingrid Druwe 7 Stephen Edwards 8 Chantra Eskes 2 Marios Georgiadis 2 Thomas Hartung 1 Aude Kienzler 2 Elisabeth Kristjansson 9 Juleen Lam 10 Laura Martino 2 Bette Meek 9 Rebecca Morgan 11 Irene Munoz-Guajardo 2 Pamela Noyes 7 Elena Parmelli 12 Aldert Piersma 13 Andrew Rooney 3 Emily Sena 14 Kristie Sullivan José Tarazona 2 Andrea Terron 2 Kris Thayer 7 Jan Turner Jos Verbeek 15 Didier Verloo 2 Mathieu Vinken 16 Sean Watford 17 Paul Whaley 1 Daniele Wikoff Kate Willett 18 Katya Tsaioun 1 
Abstract : The workshop titled "Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks" was co-organized by the Evidence-based Toxicology Collaboration and the European Food Safety Authority (EFSA), and hosted by EFSA at its headquarters in Parma, Italy on October 2 and 3, 2019. The goal was to explore integration of systematic review methods with mechanistic evidence evaluation. Participants were invited to work on concrete products to advance the exploration of how evidence-based approaches can support the development and application of adverse outcome pathways (AOP) in chemical risk assessment. The workshop discussions were centered around three related themes: 1) assessing certainty in AOPs, 2) literature-based AOP development and 3) integrating certainty in AOPs and non-animal evidence into decision frameworks. Several challenges, mostly related to methodology, were identified, and largely determined the workshop recommendations. The workshop recommendations included the comparison and potential alignment of processes used to develop AOP and systematic review methodology, including the translation of vocabulary of evidence-based methods to AOP and vice versa, the development and improvement of evidence mapping and text mining methods and tools, as well as a call for a fundamental change in chemical risk and uncertainty assessment methodology if to be conducted based on AOPs and new approach methodologies (NAM). The usefulness of evidence-based approaches for mechanism-based chemical risk assessments was stressed, particularly the potential contribution of the rigor and transparency inherent to such approaches in building stakeholders' trust for implementation of NAM evidence and AOP into chemical risk assessment.
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Submitted on : Friday, April 22, 2022 - 10:34:44 AM
Last modification on : Tuesday, April 26, 2022 - 3:33:51 AM
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Sebastian Hoffmann, Elisa Aiassa, Michelle Angrish, Claire Beausoleil, Frederic Bois, et al.. Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks. ALTEX - Alternatives to Animal Experimentation, Elsevier, In press, ⟨10.14573/altex.2202141⟩. ⟨anses-03649013⟩



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