Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks - Archive ouverte HAL Access content directly
Journal Articles ALTEX - Alternatives to Animal Experimentation Year : 2022

Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks

(1) , (2) , (3) , (4) , (5) , (2) , (6) , (1) , (2) , (7) , (8) , (2) , (2) , (1) , (2) , (9) , (10) , (2) , (9) , (11) , (2) , (7) , (12) , (13) , (3) , (14) , , (2) , (2) , (7) , , (15) , (2) , (16) , (17) , (1) , , (18) , (1)
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
Frederic Bois
  • Function : Author
Aude Kienzler
  • Function : Author
  • PersonId : 765880
  • IdRef : 176157069
Rebecca Morgan
Kristie Sullivan
  • Function : Author
Jan Turner
  • Function : Author
Daniele Wikoff
  • Function : Author

Abstract

The workshop titled "Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks" was co-organized by the Evidence-based Toxicology Collaboration and the European Food Safety Authority (EFSA), and hosted by EFSA at its headquarters in Parma, Italy on October 2 and 3, 2019. The goal was to explore integration of systematic review methods with mechanistic evidence evaluation. Participants were invited to work on concrete products to advance the exploration of how evidence-based approaches can support the development and application of adverse outcome pathways (AOP) in chemical risk assessment. The workshop discussions were centered around three related themes: 1) assessing certainty in AOPs, 2) literature-based AOP development and 3) integrating certainty in AOPs and non-animal evidence into decision frameworks. Several challenges, mostly related to methodology, were identified, and largely determined the workshop recommendations. The workshop recommendations included the comparison and potential alignment of processes used to develop AOP and systematic review methodology, including the translation of vocabulary of evidence-based methods to AOP and vice versa, the development and improvement of evidence mapping and text mining methods and tools, as well as a call for a fundamental change in chemical risk and uncertainty assessment methodology if to be conducted based on AOPs and new approach methodologies (NAM). The usefulness of evidence-based approaches for mechanism-based chemical risk assessments was stressed, particularly the potential contribution of the rigor and transparency inherent to such approaches in building stakeholders' trust for implementation of NAM evidence and AOP into chemical risk assessment.
Fichier principal
Vignette du fichier
Hoffmann_2022.pdf (605.82 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

anses-03649013 , version 1 (22-04-2022)

Licence

Attribution - CC BY 4.0

Identifiers

Cite

Sebastian Hoffmann, Elisa Aiassa, Michelle Angrish, Claire Beausoleil, Frederic Bois, et al.. Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks. ALTEX - Alternatives to Animal Experimentation, In press, ⟨10.14573/altex.2202141⟩. ⟨anses-03649013⟩

Collections

ANSES
203 View
34 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More