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Vaccine-induced rabies case in a cow (Bos taurus): Molecular characterisation of vaccine strain in brain tissue

Vlad Vuta 1 Evelyne Picard-Meyer 2 Emmanuelle Robardet 2 Gheorghe Barboi 1 Razvan Motiu 3 Florica Barbuceanu 3, 1 Constantin Vlagioiu 3 Florence Cliquet 2
1 Institute for Diagnosis and Animal Health
2 LRFSN - Laboratoire de la rage et de la faune sauvage de Nancy
3 University of Agronomic Study and Veterinary Medicine Bucharest
Abstract : Rabies is a fatal neuropathogenic zoonosis caused by the rabies virus of the Lyssavirus genus, Rhabdoviridae family. The oral vaccination of foxes - the main reservoir of rabies in Europe - using a live attenuated rabies virus vaccine was successfully conducted in many Western European countries. In July 2015, a rabies vaccine strain was isolated from the brain tissues of a clinically suspect cow (Bos taurus) in Romania. The nucleotide analysis of both N and G gene sequences showed 100% identity between the rabid animal, the GenBank reference SAD B19 strain and five rabies vaccine batches used for the national oral vaccination campaign targeting foxes.
Keywords : Rabies Fox Vaccine Pathogenicity Sequencing SAD B19
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Journal articles
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https://hal-anses.archives-ouvertes.fr/anses-03433242
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Submitted on : Wednesday, November 17, 2021 - 4:17:52 PM
Last modification on : Thursday, November 18, 2021 - 3:52:20 AM

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Vlad Vuta, Evelyne Picard-Meyer, Emmanuelle Robardet, Gheorghe Barboi, Razvan Motiu, et al.. Vaccine-induced rabies case in a cow (Bos taurus): Molecular characterisation of vaccine strain in brain tissue. Vaccine, Elsevier, 2016, 34 (41), pp.5021-5025. ⟨10.1016/j.vaccine.2016.08.013⟩. ⟨anses-03433242⟩

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