Puumala Virus Variants Circulating in Forests of Ardennes, France: Ten Years of Genetic Evolution

Guillaume Castel; Elodie Monchatre-Leroy; Marc López-Roig; Séverine Murri; Mathilde Couteaudier; Franck Boué; Denis Augot; Frank Sauvage; Dominique Pontier; Viviane Hénaux; Philippe Marianneau; Jordi Serra-Cobo; Noël Tordo

doi:10.3390/pathogens10091164

Journal articles

Puumala Virus Variants Circulating in Forests of Ardennes, France: Ten Years of Genetic Evolution

Guillaume Castel ^{1, *} Elodie Monchatre-Leroy ^{2, *} Marc López-Roig ^{3, 4} Séverine Murri ⁵ Mathilde Couteaudier ⁶ Franck Boué ² Denis Augot ^{2, 7, 8} Frank Sauvage ^{9, 10} Dominique Pontier ^{10, 11} Viviane Hénaux ⁵ Philippe Marianneau ⁵ Jordi Serra-Cobo ^{3, 4} Noël Tordo ^{12, 13, 14}

* Corresponding author

1 UMR CBGP - Centre de Biologie pour la Gestion des Populations

2 LRFSN - Laboratoire de la rage et de la faune sauvage de Nancy

3 IRBio UB - Institut de Recerca de la Biodiversitat - Biodiversity Research Institute [Barcelona, Spain]

4 Department de Biologia Evolutiva, Ecologia i Ciències Ambientals

5 Laboratoire de Lyon [ANSES]

6 MAVIVH - U1259 Inserm - CHRU Tours - Morphogénèse et antigénicité du VIH et du virus des Hépatites

7 SFR CAP Santé (Champagne-Ardenne Picardie Santé)

8 ESCAPE - Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle

9 Seenovate

10 LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558

11 LabEx Ecofect

12 Stratégies Antivirales

13 Institut Pasteur [Paris]

14 Institut Pasteur de Guinée

Abstract : In Europe, Puumala virus (PUUV) transmitted by the bank vole (Myodes glareolus) is the causative agent of nephropathia epidemica (NE), a mild form of haemorrhagic fever with renal syndrome. In France, very little is known about the spatial and temporal variability of the virus circulating within bank vole populations. The present study involved monitoring of bank vole population dynamics and PUUV microdiversity over a ten-year period (2000–2009) in two forests of the Ardennes region: Elan and Croix-Scaille. Ardennes region is characterised by different environmental conditions associated with different NE epidemiology. Bank vole density and population parameters were estimated using the capture/marking/recapture method, and blood samples were collected to monitor the overall seroprevalence of PUUV in rodent populations. Phylogenetic analyses of fifty-five sequences were performed to illustrate the genetic diversity of PUUV variants between forests. The pattern of the two forests differed clearly. In the Elan forest, the rodent survival was higher, and this limited turn-over resulted in a lower seroprevalence and diversity of PUUV sequences than in the Croix-Scaille forest. Uncovering the links between host dynamics and virus microevolution is improving our understanding of PUUV distribution in rodents and the NE risk.

Keywords : evolution microdiversity seroprevalence Myodes glareolus Orthohantavirus population dynamics

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Microbiology and Parasitology / Virology

Life Sciences [q-bio] / Biodiversity / Systematics, Phylogenetics and taxonomy

Life Sciences [q-bio] / Santé publique et épidémiologie

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https://hal-anses.archives-ouvertes.fr/anses-03388067
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Submitted on : Wednesday, October 20, 2021 - 11:00:43 AM
Last modification on : Wednesday, May 18, 2022 - 3:06:03 PM
Long-term archiving on: : Friday, January 21, 2022 - 7:33:10 PM

Puumala Virus Variants Circulating in Forests of Ardennes, France: Ten Years of Genetic Evolution

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Puumala Virus Variants Circulating in Forests of Ardennes, France: Ten Years of Genetic Evolution

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