Skip to Main content Skip to Navigation
Journal articles

Human biomonitoring initiative (HBM4EU): Human biomonitoring guidance values (HBM-GVs) derived for cadmium and its compounds

Abstract : The methodology agreed within the framework of the HBM4EU project is used in this work to derive HBM-GVs for the general population (HBM-GV GenPop) and for workers (HBM-GV Worker) exposed to cadmium (Cd) and its compounds. Methods: For Cd, a significant number of epidemiological studies with dose-response relationships are available, in particular for kidney effects. These effects are described in terms of a relation between urinary Cd (U-Cd) or blood Cd (B-Cd) levels and low molecular weight proteinuria (LMWP) markers like beta-2-microglobulin (β2M) and retinol-binding protein (RBP). In order to derive HBM-GVs for the general population and workers, an assessment of data from evaluations conducted by national or international organisations was undertaken. In this work, it appeared relevant to select renal effects as the critical effect for the both groups, however, differences between general population (including sensitive people) and workers (considered as an homogenous population of adults who should not be exposed to Cd if they suffer from renal diseases) required the selection of different key studies (i.e. conducted in general population for HBM-GV GenPop and at workplace for HBM-GV Worker). Results and conclusions: For U-Cd, a HBM-GV GenPop of 1 µg/g creatinine (creat) is recommended for adults older than 50 years, based on a robust meta-analysis performed by EFSA (EFSA, 2009a). To take into account the accumulation of Cd in the human body throughout life, threshold or 'alert' values according to age were estimated for U-Cd. At workplace, a HBM-GV Worker of 2 μg/g creat is derived from the study of Chaumont et al., (2011) for U-Cd, and in addition to this recommendation a HBM-GV worker for B-Cd of 5 µg/L is also proposed. The HBM-GV Worker for U-Cd is similar to the biological limit value (BLV) set by the new amendment of the European Carcinogens and Mutagens Directive in June 2019 (2 µg/g creat for U-Cd).
Document type :
Journal articles
Complete list of metadata

https://hal-anses.archives-ouvertes.fr/anses-03098328
Contributor : Sophie Guitton <>
Submitted on : Tuesday, January 5, 2021 - 5:04:24 PM
Last modification on : Wednesday, June 16, 2021 - 10:44:07 AM
Long-term archiving on: : Wednesday, April 7, 2021 - 9:35:57 AM

File

1-s2.0-S0160412020322923-main-...
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License

Identifiers

Collections

Citation

Farida Lamkarkach, Eva Ougier, Robert Garnier, Claude Viau, Marike Kolossa-Gehring, et al.. Human biomonitoring initiative (HBM4EU): Human biomonitoring guidance values (HBM-GVs) derived for cadmium and its compounds. Environment International, Elsevier, 2021, 147, pp.106337. ⟨10.1016/j.envint.2020.106337⟩. ⟨anses-03098328⟩

Share

Metrics

Record views

27

Files downloads

51