Mixtures of Lipophilic Phycotoxins: Exposure Data and Toxicological Assessment

Abstract : Lipophilic phycotoxins are secondary metabolites produced by phytoplanktonic species. They accumulate in filter-feeding shellfish and can cause human intoxication. Regulatory limits have been set for individual toxins, and the toxicological features are well characterized for some of them. However, phycotoxin contamination is often a co-exposure phenomenon, and toxicological data regarding mixtures effects are very scarce. Moreover, the type and occurrence of phycotoxins can greatly vary from one region to another. This review aims at summarizing the knowledge on (i) multi-toxin occurrence by a comprehensive literature review and (ii) the toxicological assessment of mixture effects. A total of 79 publications was selected for co-exposure evaluation, and 44 of them were suitable for toxin ratio calculations. The main toxin mixtures featured okadaic acid in combination with pectenotoxin-2 or yessotoxin. Only a few toxicity studies dealing with co-exposure were published. In vivo studies did not report particular mixture effects, whereas in vitro studies showed synergistic or antagonistic effects. Based on the combinations that are the most reported, further investigations on mixture effects must be carried out.
Document type :
Journal articles
Complete list of metadatas

Cited literature [118 references]  Display  Hide  Download

https://hal-anses.archives-ouvertes.fr/anses-01790013
Contributor : Emmanuelle Chiffoleau <>
Submitted on : Friday, May 11, 2018 - 3:26:26 PM
Last modification on : Tuesday, February 19, 2019 - 3:14:07 PM

File

alarcan26.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Jimmy Alarcan, Ronel Biré, Ludovic Le Hegarat, Valérie Fessard. Mixtures of Lipophilic Phycotoxins: Exposure Data and Toxicological Assessment. Marine drugs, MDPI, 2018, 16 (2), pp.1-26. ⟨10.3390/md16020046⟩. ⟨anses-01790013⟩

Share

Metrics

Record views

53

Files downloads

74