Integration of PK/PD for dose optimization of Cefquinome against Staphylococcus aureus causing septicemia in cattle - Archive ouverte HAL Access content directly
Journal Articles Frontiers in Microbiology Year : 2015

Integration of PK/PD for dose optimization of Cefquinome against Staphylococcus aureus causing septicemia in cattle

, , , (1) , , , , , , , ,
1
Ahmad Ijaz
  • Function : Author
Hao Haihong
  • Function : Author
Huang Lingli
  • Function : Author
Wang Xu
  • Function : Author
Chen Dongmei
  • Function : Author
Tao Yanfei
  • Function : Author
Xie Shuyu
  • Function : Author
Xiuhua Kuang
  • Function : Author
Li Juan
  • Function : Author
Dan Wan
  • Function : Author
Yuan Zonghui
  • Function : Author

Abstract

Cefquinome is a fourth generation cephalosporin with antimicrobial activity against gram negative and gram positive bacterial species, including Staphylococcus aureus. The aim of our study was to observe the ex-vivo activity of cefquinome against Staphylococcus aureus strains by using bovine serum from intravenously treated cattle. Cefquinome kinetics were measured by liquid chromatography and UV detection. In vitro post antibiotic effects (PAEs) and mutant prevention concentrations were determined with S. aureus strain ATCC 12598. Cefquinome exhibited time-dependent killing and produced in vitro PAEs increasing with concentration and time of exposure. A pharmacokinetic-pharmacodynamic model was established to simulate the efficacy of cefquinome for different dosage regimens. A dosage of 2 mg/kg every 12 h for 3 days was expected to reach a bactericidal activity against S. aureus in case of septicemia.

Dates and versions

anses-01203282 , version 1 (22-09-2015)

Identifiers

Cite

Ahmad Ijaz, Hao Haihong, Huang Lingli, Pascal Sanders, Wang Xu, et al.. Integration of PK/PD for dose optimization of Cefquinome against Staphylococcus aureus causing septicemia in cattle. Frontiers in Microbiology, 2015, 6, pp.588. ⟨10.3389/fmicb.2015.00588⟩. ⟨anses-01203282⟩

Collections

ANSES
63 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More