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Epidemiology and Molecular Analyses of Influenza B Viruses in Senegal from 2010 to 2019

Abstract : Influenza virus types A and B are responsible for acute viral infections that affect annually 1 billion people, with 290,000 to 650,000 deaths worldwide. In this study, we investigated the circulation of influenza B viruses over a 10-year period (2010–2019). Specimens from patients suspected of influenza infection were collected. Influenza detection was performed following RNA extraction and real-time RT-PCR. Genes coding for hemagglutinin (HA) and neuraminidase (NA) of influenza B viruses were partially sequenced, and phylogenetic analyses were carried out subsequently. During the study period, we received and tested a total of 15,156 specimens. Influenza B virus was detected in 1322 (8.7%) specimens. The mean age of influenza B positive patients was 10.9 years. When compared to reference viruses, HA genes from Senegalese circulating viruses showed deletions in the HA1 region. Phylogenetic analysis highlighted the co-circulation of B/Victoria and B/Yamagata lineage viruses with reassortant viruses. We also noted a clear seasonal pattern of circulation of influenza B viruses in Senegal.
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https://hal.archives-ouvertes.fr/hal-03691695
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Submitted on : Thursday, June 9, 2022 - 11:47:15 AM
Last modification on : Tuesday, June 14, 2022 - 9:03:46 AM
Long-term archiving on: : Saturday, September 10, 2022 - 6:45:55 PM

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Cheikh Talibouya Touré, Amary Fall, Soa Fy Andriamandimby, Mamadou Malado Jallow, Deborah Goudiaby, et al.. Epidemiology and Molecular Analyses of Influenza B Viruses in Senegal from 2010 to 2019. Viruses, MDPI, 2022, 14 (5), pp.1063. ⟨10.3390/v14051063⟩. ⟨hal-03691695⟩

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