Review and Perspectives on the Structure-Function Relationships of the Gag Subunits of Feline Immunodeficiency Virus

Mathieu Long (1, 2) , Johan Toesca (1, 3) , Christophe Guillon (1)

1 MMSB - Microbiologie moléculaire et biochimie structurale / Molecular Microbiology and Structural Biochemistry
2 Skane University Hospital [Lund]
3 EVIR - Virus enveloppés, vecteurs et immunothérapie – Enveloped viruses, Vectors and Immuno-therapy

The Gag polyprotein is implied in the budding as well as the establishment of the supramolecular architecture of infectious retroviral particles. It is also involved in the early phases of the replication of retroviruses by protecting and transporting the viral genome towards the nucleus of the infected cell until its integration in the host genome. Therefore, understanding the structure–function relationships of the Gag subunits is crucial as each of them can represent a therapeutic target. Though the field has been explored for some time in the area of Human Immunodeficiency Virus (HIV), it is only in the last decade that structural data on Feline Immunodeficiency Virus (FIV) Gag subunits have emerged. As FIV is an important veterinary issue, both in domestic cats and endangered feline species, such data are of prime importance for the development of anti-FIV molecules targeting Gag. This review will focus on the recent advances and perspectives on the structure–function relationships of each subunit of the FIV Gag polyprotein

Mots clés: Feline Immunodeficiency Virus; FIV; Human Immunodeficiency Virus; HIV; Gag; matrix; capsid; nucleocapsid; late domain; structure

Domaines: Virologie; Biologie structurale [q-bio.BM]

Mathieu Long, Johan Toesca, Christophe Guillon. Review and Perspectives on the Structure-Function Relationships of the Gag Subunits of Feline Immunodeficiency Virus. Pathogens, 2021, 10 (11), pp.1502. ⟨10.3390/pathogens10111502⟩. ⟨hal-03433930⟩