Clinical and microbiological efficacy of micafungin on Geosmithia argillacea infection in a cystic fibrosis patient

Christophe Marguet (1) , Loïc Favennec (2) , Olivier Matray (3, 4) , Sébastien Bertout (5) , Sandrine Giraud (6) , Laure Couderc (1) , Rachid Zouhair (7) , Christine Leguillon (1) , Gilles Gargala (4) , Jean-Jacques Ballet (8) , Jean-Philippe Bouchara (6)

1 Service de pédiatrie médicale et médecine de l'adolescent [Rouen]
2 PROTAL - Protozooses Transmises par l'Alimentation (Cryptosporidiose, Giardose et Toxoplasmose) : Mode de Contamination et Pathogénie (PROTAL) - EA 3800
3 ESCAPE - Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle
4 Hôpital Charles Nicolle [Rouen]
5 TransVIHMI - Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes
6 GEIHP - Groupe d'Étude des Interactions Hôte-Pathogène
7 UMI - جامعة مولاي إسماعيل = Université Moulay Ismaïl
8 Immunology Department, Caen University Hospital,

Cystic fibrosis (CF) patients are at high risk of colonization of the airways by a number of fungi, including the emerging opportunistic fungus Geosmithia argillacea. We report the eradication of respiratory G. argillacea associated with clinical resolution of severe symptoms by high-dose and prolonged micafungin therapy in a young CF patient.

Mots clés: Cystic fibrosis; Geosmithia argillacea; Micafungin; Pulmonary exacerbation

Domaines: Sciences du Vivant [q-bio]

Christophe Marguet, Loïc Favennec, Olivier Matray, Sébastien Bertout, Sandrine Giraud, et al.. Clinical and microbiological efficacy of micafungin on Geosmithia argillacea infection in a cystic fibrosis patient. Medical Mycology Case Reports, 2012, 1 (1), pp.79 - 81. ⟨10.1016/j.mmcr.2012.08.004⟩. ⟨hal-03134624⟩