A novel BoLA class II molecule with a tissue distribution different from BoLA-DR or BoLA-DQ molecules

Distribution tissulaire d'une molécule de classe II du BoLA distincte de BoLA-DR et -DQ

A. Ababou (1, 2) , Françoise Féménia (3) , François Crespeau (1) , Jean-Jacques Fontaine (1) , Wc Davis (1) , Daniel Levy (1, 2)

1 ENVA - École nationale vétérinaire d'Alfort
2 INRA - Institut National de la Recherche Agronomique
3 Unité mixte de recherche biologie moléculaire et immunologie parasitaires et fongiques

This study was designed to investigate the lymphoid tissue distribution of a new BoLA class II molecule defined by a unique monoclonal antibody H42A. We immunostained various lymphoid organs of 4-month-old Holstein calves with this monoclonal antibody and compared its tissue distribution to the BoLA-DR and BoLA-DQ expressions. Our results demonstrate a unique tissue distribution of the H42A-defined molecules, restricted to epithelial cells of the thymic medulla but extending in the periphery to the different cells involved in antigen presentation (B-cells, macrophages and dendritic cells). The peculiar distribution of this new BoLA class II molecule suggests that it has a specific function.

Domaines: Médecine vétérinaire et santé animale; Immunologie

A. Ababou, Françoise Féménia, François Crespeau, Jean-Jacques Fontaine, Wc Davis, et al.. A novel BoLA class II molecule with a tissue distribution different from BoLA-DR or BoLA-DQ molecules. Veterinary Research, 1995, 26, pp.319-327. ⟨hal-02703211⟩