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Journal articles
Comparative analysis of both genomic segments of betanodaviruses isolated from epizootic outbreaks in farmed fish species provides evidence for genetic reassortment.
Abstract : Sequencing of the full coding region of both genomic segments of seven betanodavirus strains isolated from different farmed species in Spain and Portugal revealed that six of them were reassortants, exhibiting a RGNNV RNA1 and a SJNNV RNA2. Analysis of sequences of reassortant strains at both genomic and protein level revealed the existence of differences with type strains of both genotypes. These differences were higher in the polymerase sequence, which is remarkable because viral structural proteins generally diverge more rapidly than non-structural proteins. Changes in two amino acids observed in the SJNNV capsid protein might be involved in the colonization of new host species by these reassortant strains. In addition, a more extensive phylogenetic analysis, including partial sequences of both RNA segments of other 16 Iberian nodavirus, confirmed the existence of reassortment between RGNNV and SJNNV.
https://hal-anses.archives-ouvertes.fr/hal-00418441
Contributor : Françoise Bautey Connect in order to contact the contributor
Submitted on : Friday, September 18, 2009 - 3:41:32 PM
Last modification on : Tuesday, August 18, 2020 - 5:00:16 PM
Contributor : Françoise Bautey Connect in order to contact the contributor
Submitted on : Friday, September 18, 2009 - 3:41:32 PM
Last modification on : Tuesday, August 18, 2020 - 5:00:16 PM
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