Spread of the blaOXA-48 /IncL Plasmid within and between Dogs in City Parks, France

Marisa Haenni (1, 2, 3) , Véronique Métayer (1, 2, 3) , Agnese Lupo (1, 2, 3) , Antoine Drapeau (1, 2, 3) , Jean-Yves Madec (1, 2, 3)

1 Université de Lyon
2 Laboratoire de Lyon [ANSES]
3 AVB - Unité Antibiorésistance et Virulence Bactériennes

The blaOXA-48/IncL plasmid is increasingly reported in dogs, even in the absence of carbapenem use in animals. In this study, we witnessed the spread of this plasmid within and between dogs sharing the same relaxing area. This indicates a very dynamic situation where carbapenem resistance can be transmitted between dogs and expanded in the dogs' gut. As a consequence, picking up dog feces may lower both this dynamic and the global antimicrobial resistance burden. IMPORTANCE The use of carbapenems in animals is forbidden in France due to their critical importance to treat human diseases. Nevertheless, blaOXA-48-producing Enterobacterales were sporadically recovered in cats and dogs, most likely as a spill over from the human reservoir. This study highlights the rapid spread of blaOXA-48 once transmitted to dogs, suggesting that companion animals can play a role in the transmission routes of carbapenemase genes.

Mots clés: OXA-48; dog; transmission

Domaines: Bactériologie

Marisa Haenni, Véronique Métayer, Agnese Lupo, Antoine Drapeau, Jean-Yves Madec. Spread of the blaOXA-48 /IncL Plasmid within and between Dogs in City Parks, France. Microbiology Spectrum, 2022, 10 (3), pp.e0040322. ⟨10.1128/spectrum.00403-22⟩. ⟨anses-03971804⟩