New Mycobacterium bovis complete genomes of different clonal complexes to improve molecular epidemiology of french field strains

Ciriac Charles (1, 2) , Lorraine Michelet (1, 3) , Fabien Vorimore (3, 4) , Cyril Conde (2) , Thierry Cochard (2) , Franck Biet (2) , Maria‐laura Boschiroli (1)

1 UZB - Unité Zoonoses Bactériennes
2 UMR ISP - Infectiologie et Santé Publique
3 UPE - Université Paris-Est
4 LSAl - Laboratoire de sécurité des aliments de Maisons-Alfort

Bovine Tuberculosis (bTB) is a zoonotic disease due to Mycobacterium bovis (M. bovis). France has a bTB-free status, but the disease has not been eradicated yet and a worryingly steady increase of bTB outbreaks has been observed in some regions (1). This could be explained by the detection of bTB in wildlife that spills it back to livestock in the same territories. The transmission link within these multi-host systems remains difficult to establish given that they share the same M. bovis genotypes (2). Obtaining new reference genomes for each of these genotypes could improve the knowledge of clonal groups and refine molecular field epidemiology studies based on whole genome sequencing.

Keywords: mycobacterium bovis; genome; lineages

Domains: Genomics [q-bio.GN]

Ciriac Charles, Lorraine Michelet, Fabien Vorimore, Cyril Conde, Thierry Cochard, et al.. New Mycobacterium bovis complete genomes of different clonal complexes to improve molecular epidemiology of french field strains. Annual scientific meeting 2022, Apr 2022, Orvieto, Italy. ⟨anses-03947216⟩