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Journal articles

Toxicity of palytoxin, purified ovatoxin-a, ovatoxin-d and extracts of Ostreopsis cf. ovata on the Caco-2 intestinal barrier model

Abstract : Human intoxications in the Mediterranean Sea have been linked to blooms of the dinoflagellate Ostreopsis cf. ovata, producer of palytoxin (PlTX)-like toxins called ovatoxins (OVTXs). Exposure routes include only inhalation and contact, although PlTX-poisoning by seafood has been described in tropical regions. To address the impact of OVTXs on the intestinal barrier, dinoflagellate extracts, purified OVTX-a and -d and PlTX were tested on differentiated Caco-2 cells. Viability, inflammatory response and barrier integrity were recorded after 24h treatment. OVTX-a and -d were not cytotoxic up to 20ng/mL but increased IL-8 release, although to a lesser extent compared to PlTX. While PlTX and OVTX-a (at 0.5 and 5ng/mL respectively) affected intestinal barrier integrity OVTX-d up to 5ng/mL did not. Overall, OVTX-d was shown to be less toxic than OVTX-a and PlTX. Therefore, oral exposure to OVTX-a and -d could provoked lower acute toxicity than PlTX.
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https://hal-anses.archives-ouvertes.fr/anses-03701528
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Submitted on : Wednesday, June 22, 2022 - 11:15:31 AM
Last modification on : Friday, July 1, 2022 - 5:42:10 PM

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Marin-Pierre Gemin, Rachelle Lanceleur, Lisa Meslier, Fabienne Herve, Damien Reveillon, et al.. Toxicity of palytoxin, purified ovatoxin-a, ovatoxin-d and extracts of Ostreopsis cf. ovata on the Caco-2 intestinal barrier model. Environmental Toxicology and Pharmacology, Elsevier, 2022, pp.103909. ⟨10.1016/j.etap.2022.103909⟩. ⟨anses-03701528⟩

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