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Journal Articles Viruses Year : 2019

Shared Common Ancestry of Rodent Alphacoronaviruses Sampled Globally

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Theocharis Tsoleridis
  • Function : Author
  • PersonId : 1138249
Joseph G Chappell
Charles P Mcclure
Jonathan K Ball
  • Function : Author
  • PersonId : 989760

Abstract

The recent discovery of novel alphacoronaviruses (alpha-CoVs) in European and Asian rodents revealed that rodent coronaviruses (CoVs) sampled worldwide formed a discrete phylogenetic group within this genus. To determine the evolutionary history of rodent CoVs in more detail, particularly the relative frequencies of virus-host co-divergence and cross-species transmission, we recovered longer fragments of CoV genomes from previously discovered European rodent alpha-CoVs using a combination of PCR and high-throughput sequencing. Accordingly, the full genome sequence was retrieved from the UK rat coronavirus, along with partial genome sequences from the UK field vole and Poland-resident bank vole CoVs, and a short conserved ORF1b fragment from the French rabbit CoV. Genome and phylogenetic analysis showed that despite their diverse geographic origins, all rodent alpha-CoVs formed a single monophyletic group and shared similar features, such as the same gene constellations, a recombinant beta-CoV spike gene, and similar core transcriptional regulatory sequences (TRS). These data suggest that all rodent alpha CoVs sampled so far originate from a single common ancestor, and that there has likely been a long-term association between alpha CoVs and rodents. Despite this likely antiquity, the phylogenetic pattern of the alpha-CoVs was also suggestive of relatively frequent host-jumping among the different rodent species.
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Origin : Publication funded by an institution

Dates and versions

anses-03388167 , version 1 (20-10-2021)

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Theocharis Tsoleridis, Joseph G Chappell, Okechukwu Onianwa, Denise A. Marston, Anthony R Fooks, et al.. Shared Common Ancestry of Rodent Alphacoronaviruses Sampled Globally. Viruses, 2019, 11 (2), pp.125. ⟨10.3390/v11020125⟩. ⟨anses-03388167⟩

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