Guidance Level for Brevetoxins in French Shellfish - Archive ouverte HAL Access content directly
Journal Articles Marine drugs Year : 2021

Guidance Level for Brevetoxins in French Shellfish

(1) , (2) , (3) , (4) , (5) , (1) , (6) , (7) , (8) , (9, 10) , (11)
1
2
3
4
5
6
7
8
9
10
11

Abstract

Brevetoxins (BTXs) are marine biotoxins responsible for neurotoxic shellfish poisoning (NSP) after ingestion of contaminated shellfish. NSP is characterized by neurological, gastrointestinal and/or cardiovascular symptoms. The main known producer of BTXs is the dinoflagellate Karenia brevis, but other microalgae are also suspected to synthesize BTX-like compounds. BTXs are currently not regulated in France and in Europe. In November 2018, they have been detected for the first time in France in mussels from a lagoon in the Corsica Island (Mediterranean Sea), as part of the network for monitoring the emergence of marine biotoxins in shellfish. To prevent health risks associated with the consumption of shellfish contaminated with BTXs in France, a working group was set up by the French Agency for Food, Environmental and Occupational Health & Safety (Anses). One of the aims of this working group was to propose a guidance level for the presence of BTXs in shellfish. Toxicological data were too limited to derive an acute oral reference dose (ARfD). Based on human case reports, we identified two lowest-observed-adverse-effect levels (LOAELs). A guidance level of 180 µg BTX-3 eq./kg shellfish meat is proposed, considering a protective default portion size of 400 g shellfish meat.
Fichier principal
Vignette du fichier
Arnich_Marine Drugs_2021_v3.pdf (6.12 Mo) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

anses-03350437 , version 1 (21-09-2021)

Licence

Attribution - CC BY 4.0

Identifiers

Cite

Nathalie Arnich, Eric Abadie, Zouher Amzil, Marie-Yasmine Dechraoui Bottein, Katia Comte, et al.. Guidance Level for Brevetoxins in French Shellfish. Marine drugs, 2021, 19 (9), pp.520. ⟨10.3390/md19090520⟩. ⟨anses-03350437⟩
89 View
77 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More