Biomonitoring of fast-elimination endocrine disruptors – Results from a 6-month follow up on human volunteers with repeated urine and hair collection

François Fäys (1, 2) , Emilie M Hardy (1) , Paul Palazzi (1) , Serge Haan (2) , Claire Beausoleil (3) , Brice M R Appenzeller (1)

1 LIH - Luxembourg Institute of Health
2 University of Luxembourg [Luxembourg]
3 DER - Direction de l'Evaluation des Risques

Hair Urine Endocrine disruptor Biomarkers of exposure Results: All the biomarkers analyzed were detected in at least one of the two matrices. 21 biomarkers were more frequently detected in hair, 6 in urine, and 1 was equivalent. Biomarkers intraclass correlation coefficients (ICC) ranged from 0.1 to 0.8 (ten above 0.4) in hair, and from 0.09 to 0.51 in urine (two above 0.4). The concentrations of biomarkers in hair and urine were significantly correlated for only one compound. Conclusion: This study highlights the complexity of assessing exposure to fast-elimination ED and suggests considering with caution the specificity of the matrix in data interpretation. The results document the respective advantages and limitations of urine and hair, and provide new insight in the understanding of the information provided by these biological matrices and their relevance for the assessment of human exposure to fast elimination contaminants. Capsule: 92 hair and 805 urine samples collected from 16 volunteers over 6 months, tested for phthalate metabolites, bisphenols and pesticides. 19 biomarkers (in hair) and 24 (in urine) were detected in >50% of the samples.

Mots clés: Biomonitoring; Gas chromatography; Liquid chromatography; Limit of detection; Limit of quantifications; Bisphenol A BPA; Bisphenol F BPF; Bisphenol S BPS; Biomarkers of exposure; Endocrine disruptor; Hair; Urine analysis

Domaines: Toxicologie

François Fäys, Emilie M Hardy, Paul Palazzi, Serge Haan, Claire Beausoleil, et al.. Biomonitoring of fast-elimination endocrine disruptors – Results from a 6-month follow up on human volunteers with repeated urine and hair collection. Science of the Total Environment, 2021, 778, pp.146330. ⟨10.1016/j.scitotenv.2021.146330⟩. ⟨anses-03318247⟩