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Subclinical BCG-osis in a Captive Badger (Meles meles) with Lymphoma

C. Bianco 1 S. Lesellier 2 J. Barrat 3 C. Richomme 3 M.-L. Boschiroli 4 A. Núñez 2
1 APHA - Animal and Plant Health Agency
2 APHA - Animal and Plant Health Agency [Weybridge]
3 LRFSN - Laboratoire de la rage et de la faune sauvage de Nancy
4 Laboratoire de santé animale, sites de Maisons-Alfort et de Dozulé
Abstract : Subclinical systemic dissemination of Bacillus Calmette-Guérin (BCG) is described in a captive badger (Meles meles) with lymphoma. An adult female European badger was vaccinated per os with BCG and after 8 weeks post-mortem examination identified marked lymphadenomegaly and multinodular hepatic lesions. The histopathology and immunohistochemistry confirmed a multicentric T-cell lymphoma, associated with high BCG bacterial load in numerous tissues. The histology did not identify BCG-associated lesions. The scenario suggested that the T-cell lymphoma likely favoured the dissemination of the BCG ('BCG-osis'). Given that lymphoma is rare in badgers, this neoplasm should not interfere with the efficacy of large-scale vaccination programmes.
Keywords : Bacillus Calmette–Guérin Badger Lymphoma Mycobacterium
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Journal articles
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https://hal-anses.archives-ouvertes.fr/anses-03294027
Contributor : Sophie Marchal-Mauer Connect in order to contact the contributor
Submitted on : Wednesday, July 21, 2021 - 1:43:02 PM
Last modification on : Wednesday, November 3, 2021 - 7:35:18 AM

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C. Bianco, S. Lesellier, J. Barrat, C. Richomme, M.-L. Boschiroli, et al.. Subclinical BCG-osis in a Captive Badger (Meles meles) with Lymphoma. Journal of Comparative Pathology, Elsevier, 2020, 176, pp.76-80. ⟨10.1016/j.jcpa.2020.02.009⟩. ⟨anses-03294027⟩

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