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Refinement of health-based guidance values for cadmium in the French population based on modelling

Abstract : In France, part of the population is overexposed to cadmium by the diet. In our work, we first revised the tolerable daily intake (TDI) of 0.36 μg Cd.kg bw.d.-1 proposed by the European Food Safety Authority (EFSA), derived from effects on kidneys and based on the critical urinary Cd concentration of 1.0 μg Cd.g-1 creatinine for humans. After reviewing the epidemiological data on Cd toxicity published after 2011, bone effects were selected as the critical effects. Body burden data of 0.5 µg.g-1 creatinine was chosen for the critical threshold for human urinary cadmium concentrations. To be used for the derivation of the new oral toxicological reference value, we used a modified physiologically based pharmacokinetic model (PBPK). The reverse calculation on the PBPK model gave a TDI of 0.35 µg Cd.kg bw-1.day-1. This TDI is compatible with a urinary Cd concentrations not exceeding 0.5 µg Cd.g-1 creatinine, in a 60 year-old adult, assuming that ingestion is the only source of exposure to Cd at 60 years. After implementing the PBPK model with French physiological data, Cd biological reference values as a function of age were modelled so as to remain below the revised health-based guidance values.
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https://hal-anses.archives-ouvertes.fr/anses-03106940
Contributor : Sophie Guitton <>
Submitted on : Tuesday, January 12, 2021 - 11:30:51 AM
Last modification on : Monday, February 22, 2021 - 5:48:03 PM

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Stéphane Leconte, Christophe Rousselle, Laurent Bodin, François Clinard, Géraldine Carne. Refinement of health-based guidance values for cadmium in the French population based on modelling. Toxicology Letters, Elsevier, 2021, ⟨10.1016/j.toxlet.2020.12.021⟩. ⟨anses-03106940⟩

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