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Journal Articles Journal of Inorganic Biochemistry Year : 2020

Early postnatal injections of whole vaccines compared to placebo controls: Differential behavioural outcomes in mice

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Housam Eidi
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  • PersonId : 767161
  • IdRef : 16011604X
Janice Yoo
  • Function : Author
Suresh Bairwa
  • Function : Author
Michael Kuo
  • Function : Author
Eric Sayre
  • Function : Author
Lucija Tomljenovic
  • Function : Author
Christopher Shaw
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Abstract

The present study was designed to evaluate the possible effects of the paediatric vaccination schedule in the United States on the central nervous system in a murine model. We compared the impact of treatment with the whole vaccines versus true placebo control. Seventy-six pups were divided into three groups: two vaccinated groups and unvaccinated control. The two vaccinated groups were treated between 7 and 21 post-natal days either with one or three times of the vaccine doses per body weight as used in children between newborn and eighteen months of age. The post-vaccination development, neuromotor behaviours and neurobehavioural abnormalities (NBAs) were evaluated in all mouse groups during the 67 post-natal weeks of mouse age. Mouse body weight was affected only in the vaccinated females compared to males and control. Some NBAs such as decreased sociability, increased anxiety-like behaviours, and alteration of visual-spatial learning and memory were observed in vaccinated male and female mice compared to controls. The present study also shows a slower acquisition of some neonatal reflexes in vaccinated female mice compared to vaccinated males and controls. The observed neurodevelopmental alterations did not show a linear relationship with vaccine dose, suggesting that the single dose gave a saturated response. The outcomes seemed to be sex-dependent and transient with age.
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anses-03080307 , version 1 (17-10-2022)

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Attribution - NonCommercial - CC BY 4.0

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Housam Eidi, Janice Yoo, Suresh Bairwa, Michael Kuo, Eric Sayre, et al.. Early postnatal injections of whole vaccines compared to placebo controls: Differential behavioural outcomes in mice. Journal of Inorganic Biochemistry, 2020, 212, pp.111200. ⟨10.1016/j.jinorgbio.2020.111200⟩. ⟨anses-03080307⟩

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