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Journal Articles Regulatory Toxicology and Pharmacology Year : 2020

Assessment of veterinary drug residues in food: Considerations when dealing with sub-optimal data

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Alan Chicoine
  • Function : Author
  • PersonId : 1086100
Holly Erdely
  • Function : Author
Vittorio Fattori
  • Function : Author
Anke Finnah
  • Function : Author
Samuel Fletcher
  • Function : Author
Markus Lipp
  • Function : Author
Pascal Sanders
Stefan Scheid
  • Function : Author

Abstract

The use of veterinary drugs in food-producing animals may lead to residues in animal-derived foodstuffs, potentially posing a risk to human safety. While the process of veterinary drug residue risk assessment continues to evolve as new data emerges, a recurring challenge is when sub-optimal or incomplete data are provided with the expectation of supporting a robust risk assessment. The Joint FAO/WHO Expert Committee on Food Additives (JECFA) is comprised of international experts who routinely deal with such data challenges when performing veterinary drug residue evaluations. Recent developments in veterinary drug residue risk assessment are described, including specific consequences of sub-optimal data during the risk assessment process. When feasible, practical solutions to such challenges are also highlighted. Case examples from recent JECFA veterinary drug evaluations are provided to clearly quantify and illustrate the concepts described. The information provided is intended to facilitate the generation of improved quality data, enabling more timely and robust veterinary drug residue risk assessments.
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Dates and versions

anses-03069175 , version 1 (15-12-2020)

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Attribution - NonCommercial - NoDerivatives - CC BY 4.0

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Alan Chicoine, Holly Erdely, Vittorio Fattori, Anke Finnah, Samuel Fletcher, et al.. Assessment of veterinary drug residues in food: Considerations when dealing with sub-optimal data. Regulatory Toxicology and Pharmacology, 2020, 118, pp.104806. ⟨10.1016/j.yrtph.2020.104806⟩. ⟨anses-03069175⟩

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