From Basic Research to New Tools and Challenges for the Genotoxicity Testing of Nanomaterials

Valérie Fessard (1) , Fabrice Nesslany (2)

1 Laboratoire de Fougères - ANSES
2 Institut Pasteur de Lille

Genotoxicity is one of the key endpoints investigated as early as possible before marketing a product. Several assays can be performed to evaluate the genotoxicity and mutagenicity of compounds, covering the detection of DNA lesions and of DNA repair activities as well as the quantification of the three types of mutations at the gene, chromosome and genome levels. Most of these tests have an established or draft guideline from the Organization for Economic Co-operation and Development (OECD). Nevertheless, if these assays have been developed for chemicals, they are not fully suitable for testing the genotoxicity/mutagenicity of nanomaterials, and the adaptation of the experimental conditions for such compounds is still debated. This Special Issue “From Basic Research to New Tools and Challenges for the Genotoxicity Testing of Nanomaterials” aimed to provide new results on a large range of nanomaterials using a broad panel of genotoxicity assays and to solve some of the numerous issues faced on this topic.

Keywords: nanomaterial; genotoxicity test; toxicology; toxicity test

Keywords: génotoxicité; test; toxicité; toxicologie

Domains: Toxicology

Valérie Fessard, Fabrice Nesslany. From Basic Research to New Tools and Challenges for the Genotoxicity Testing of Nanomaterials. Nanomaterials, 2020, 10 (10), pp.2073. ⟨10.3390/nano10102073⟩. ⟨anses-03017173⟩