From Basic Research to New Tools and Challenges for the Genotoxicity Testing of Nanomaterials - Archive ouverte HAL Access content directly
Journal Articles Nanomaterials Year : 2020

From Basic Research to New Tools and Challenges for the Genotoxicity Testing of Nanomaterials

(1) , (2)
1
2

Abstract

Genotoxicity is one of the key endpoints investigated as early as possible before marketing a product. Several assays can be performed to evaluate the genotoxicity and mutagenicity of compounds, covering the detection of DNA lesions and of DNA repair activities as well as the quantification of the three types of mutations at the gene, chromosome and genome levels. Most of these tests have an established or draft guideline from the Organization for Economic Co-operation and Development (OECD). Nevertheless, if these assays have been developed for chemicals, they are not fully suitable for testing the genotoxicity/mutagenicity of nanomaterials, and the adaptation of the experimental conditions for such compounds is still debated. This Special Issue “From Basic Research to New Tools and Challenges for the Genotoxicity Testing of Nanomaterials” aimed to provide new results on a large range of nanomaterials using a broad panel of genotoxicity assays and to solve some of the numerous issues faced on this topic.
Fichier principal
Vignette du fichier
fessardMDPI2020_1.pdf (178.05 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

anses-03017173 , version 1 (20-11-2020)

Licence

Attribution - CC BY 4.0

Identifiers

Cite

Valérie Fessard, Fabrice Nesslany. From Basic Research to New Tools and Challenges for the Genotoxicity Testing of Nanomaterials. Nanomaterials, 2020, 10 (10), pp.2073. ⟨10.3390/nano10102073⟩. ⟨anses-03017173⟩
28 View
84 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More