. Hazard and . Mater, , vol.393, 122419.

J. C. Bart, Polymer/additive analysis by flash pyrolysis techniques1Presented at 264 Pyrolysis, J. Anal. Appl. Pyrolysis, vol.58, pp.160-161, 2000.

C. Lahimer, M. Ayed, N. Horriche, J. Belgaied, and S. , Characterization of plastic 267 packaging additives: Food contact, stability and toxicity, Arab. J. Chem, vol.10, pp.1938-268, 2017.

S. Coffin, G. Huang, I. Lee, and D. Schlenk, Fish and Seabird Gut Conditions Enhance 270 Desorption of Estrogenic Chemicals from Commonly-Ingested Plastic Items, 2019.

, Sci. Technol, vol.53, pp.4588-4599

H. L. De-frond, E. Van-sebille, J. M. Parnis, M. L. Diamond, N. Mallos et al., , p.273

C. M. Rochman, Estimating the mass of chemicals associated with ocean plastic 274 pollution to inform mitigation efforts, Integr. Environ. Assess. Manag, vol.15, pp.596-606, 2019.

F. De-mendiburu, agricolae: statistical procedures for agricultural research, 2017.

, Package Version 12-8

M. S. Dopico-garcía, J. M. López-vilariñó, and M. V. González-rodríguez, Antioxidant 280 Content of and Migration from Commercial Polyethylene, Polypropylene, and 281 Polyvinyl Chloride Packages, J. Agric. Food Chem, vol.55, pp.3225-3231, 2007.

,

B. O. Ekpo, O. E. Oyo-ita, D. R. Oros, and B. R. Simoneit, Sources of Organic 284 Contaminants in Solvents and Implications for Geochemistry and Environmental 285 Forensics: An Example from Local Vendors in Nigeria, Environ. Forensics, vol.13, pp.1-6, 2012.

H. El-mansouri, N. Yagoubi, and D. Ferrier, Extraction of polypropylene additives and their 288 analysis by HPLC, Chromatographia, vol.48, p.491, 1998.

, Mapping exercise -Plastic additives initiative, European Chemicals Agency, 2019.

. Document,

K. Fouyer, O. Lavastre, and D. Rondeau, Direct Monitoring of the Role Played by a 293 Stabilizer in a Solid Sample of Polymer Using Direct Analysis in Real Time Mass 294 Spectrometry: The Case of Irgafos 168 in Polyethylene, Anal. Chem, vol.84, pp.8642-8649, 2012.

E. Fries, J. H. Dekiff, J. Willmeyer, M. Nuelle, M. Ebert et al., Identification 297 of polymer types and additives in marine microplastic particles using pyrolysis-GC/MS 298 and scanning electron microscopy, Environ. Sci. Process. Impacts, vol.15, pp.1949-1956, 2013.

F. Galgani, G. Hanke, and T. Maes, Global Distribution, Composition and Abundance of 301 Marine Litter, pp.29-56, 2015.

J. A. Garde, R. Catalá, and R. Gavara, Global and Specific Migration of Antioxidants from 305 Polypropylene Films into Food Simulants, J. Food Prot, vol.61, pp.1000-1006, 1998.

,

T. Gardon, A. Huvet, I. Paul-pont, A. Cassone, M. Sham-koua et al., , p.308

J. Receveur and G. Le-moullac, Toxic effects of leachates from plastic pearl-309 farming gear on embryo-larval development in the pearl oyster Pinctada margaritifera, 2020.

, Water Res, vol.179, 115890.

R. Geyer, J. R. Jambeck, and K. L. Law, Production, use, and fate of all plastics ever made, 2017.

. Sci and . Adv,

J. N. Hahladakis, C. A. Velis, R. Weber, E. Iacovidou, and P. Purnell, An overview of 314 chemical additives present in plastics: Migration, release, fate and environmental impact 315 during their use, disposal and recycling, J. Hazard. Mater, vol.344, pp.179-199, 2018.

,

M. Hammond, H. Nunn, G. Rogers, H. Lee, A. Marghitoiu et al., Identification of a Leachable 319 Compound Detrimental to Cell Growth in Single-Use Bioprocess Containers, PDA J, 2013.

, Pharm. Sci. Technol, vol.67, pp.123-134

L. Hermabessiere, A. Dehaut, I. Paul-pont, C. Lacroix, R. Jezequel et al., Occurrence and effects of plastic additives on marine environments and 323 organisms: a review, Chemosphere, vol.322, pp.781-793, 2017.

,

A. A. Horton, A. Walton, D. J. Spurgeon, E. Lahive, and C. Svendsen, Microplastics in 326 freshwater and terrestrial environments: Evaluating the current understanding to 327 identify the knowledge gaps and future research priorities, Sci. Total Environ, vol.586, pp.127-328, 2017.

M. Jang, W. J. Shim, G. M. Han, M. Rani, Y. K. Song et al., Styrofoam Debris 330 as a Source of Hazardous Additives for Marine Organisms, Environ. Sci. Technol, vol.50, pp.4951-4960, 2016.

P. S. Kelly, S. Mcsweeney, O. Coleman, S. Carillo, M. Henry et al., Process-relevant concentrations 334 of the leachable bDtBPP impact negatively on CHO cell production characteristics, 2016.

, Biotechnol. Prog, vol.32, pp.1547-1558

L. Lebreton, M. Egger, and B. Slat, A global mass budget for positively buoyant 337 macroplastic debris in the ocean, Sci. Rep, vol.9, 2019.

L. Lebreton, B. Slat, F. Ferrari, B. Sainte-rose, J. Aitken et al., , p.340

S. Cunsolo, A. Schwarz, A. Levivier, K. Noble, P. Debeljak et al., , p.341

R. Argent, R. Brambini, and J. Reisser, Evidence that the Great Pacific Garbage 342 Patch is rapidly accumulating plastic, 2018.

R. Lenz, K. Enders, and T. G. Nielsen, Microplastic exposure studies should be 345 environmentally realistic, Proc. Natl. Acad. Sci. 113, E4121, vol.346, 2016.

R. Liu and S. A. Mabury, Unexpectedly High Concentrations of a Newly Identified 348, 2018.

, Tris(2,4-di-tert-butylphenyl) Phosphate, in Indoor Dust from, Organophosphate Ester

, Canada. Environ. Sci. Technol, vol.52, pp.9677-9683

A. Lusher, Microplastics in the Marine Environment: Distribution, Interactions and 351 Effects, 2015.

B. Marcato, S. Guerra, M. Vianello, and S. Scalia, Migration of antioxidant additives from 354 various polyolefinic plastics into oleaginous vehicles, Int. J. Pharm, vol.257, pp.217-225, 2003.

S. Net, A. Delmont, R. Sempéré, A. Paluselli, and B. Ouddane, Reliable quantification of 357 phthalates in environmental matrices (air, water, sludge, sediment and soil): A review, 2015.

, Sci. Total Environ, pp.162-180

J. Oehlmann, U. Schulte-oehlmann, W. Kloas, O. Jagnytsch, I. Lutz et al., , p.360

L. Wollenberger, E. M. Santos, G. C. Paull, K. J. Van-look, and C. R. Tyler, A 361 critical analysis of the biological impacts of plasticizers on wildlife, Philos. Trans. R, 2009.

, Soc. Lond. B Biol. Sci, vol.364, pp.2047-2062

. Plasticseurope, Plastics -the Facts 2019: An analysis of European plastics production, 364 demand and waste data, 2019.

, URL, vol.365

. R-core-team, R: A language and environment for statistical computing, p.368, 2018.

M. Rani, W. J. Shim, G. M. Han, M. Jang, N. A. Al-odaini et al., , 2015.

, Qualitative Analysis of Additives in Plastic Marine Debris and Its New Products. Arch

, Environ. Contam. Toxicol, vol.69, pp.352-366

M. Rani, W. J. Shim, G. M. Han, M. Jang, Y. K. Song et al., Benzotriazole-type 373 ultraviolet stabilizers and antioxidants in plastic marine debris and their new products, 2017.

, Sci. Total Environ, vol.579, pp.745-754

, RStudio Integr. Dev. Environ. R. URL, 2016.

R. R. Shah, T. W. Linville, A. D. Whynot, and C. S. Brazel, Evaluating the toxicity of 378 bDtBPP on CHO-K1 cells for testing of single-use bioprocessing systems considering 379 media selection, cell culture volume, mixing, and exposure duration, Biotechnol. Prog, vol.380, pp.1318-1323, 2016.

A. M. Soto, H. Justicia, J. W. Wray, and C. Sonnenschein, p-Nonyl-phenol: an estrogenic 382 xenobiotic released from "modified" polystyrene, Environ. Health Perspect, vol.92, pp.167-383, 1991.

T. J. Suhrhoff and B. M. Scholz-böttcher, Qualitative impact of salinity, UV radiation and 385 turbulence on leaching of organic plastic additives from four common plastics -A lab 386 experiment, Mar. Pollut. Bull, vol.102, pp.84-94, 2016.

K. Tanaka, H. Takada, R. Yamashita, K. Mizukawa, M. Fukuwaka et al., , 2015.

, Facilitated Leaching of Additive-Derived PBDEs from Plastic by Seabirds' Stomach 390 Oil and Accumulation in Tissues, Environ. Sci. Technol, vol.49, pp.11799-11807

Y. Wu, M. Venier, and R. A. Hites, Identification of Unusual Antioxidants in the Natural 410 and Built Environments, Environ. Sci. Technol. Lett, vol.6, pp.443-447, 2019.

,

Y. Yang, C. Hu, H. Zhong, X. Chen, R. Chen et al., Effects of Ultraviolet (UV) 413 on Degradation of Irgafos 168 and Migration of Its Degradation Products from 414 Polypropylene Films, J. Agric. Food Chem, vol.64, pp.7866-7873, 2016.

X. Ye, X. Zhou, R. Hennings, J. Kramer, and A. M. Calafat, Potential external 417 contamination with bisphenol A and other ubiquitous organic environmental chemicals 418 during biomonitoring analysis: an elusive laboratory challenge. Environ. Health 419 Perspect, vol.121, pp.283-286, 2013.

L. Zimmermann, G. Dierkes, T. A. Ternes, C. Völker, and M. Wagner, Benchmarking the 421 in Vitro Toxicity and Chemical Composition of Plastic Consumer Products, 2019.

, Sci. Technol, vol.53, pp.11467-11477

, Ludovic HERMABESSIERE: Conceptualization; Investigation

, Writing -Original Draft; Writing -Review and Editing 428 Justine RECEVEUR: Investigation 429 Charlotte HIMBER: Resources; Investigation

M. David, Conceptualization Writing -Review and Editing 431 Arnaud HUVET: Conceptualization; Writing -Review and Editing 432 Fabienne LAGARDE: Conceptualization; Writing -Review and Editing

L. Christophe, Conceptualization; Writing -Review and Editing, p.434

P. Ika, Conceptualization; Writing -Review and Editing, p.435

D. Alexandre, Conceptualization; Resources; Investigation; Visualization; Writing -436 Review and Editing 437 Ronan JEZEQUEL: Investigation; Conceptualization; Writing -Review and Editing 438 Philippe SOUDANT: Conceptualization; Writing -Review and Editing

, Guillaume DUFLOS: Conceptualization; Resources, Writing -Review and Editing