, Safety of aluminium from dietary intake-Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials (AFC), EFSA J, vol.6, p.754, 2008.

C. C. Willhite, N. A. Karyakina, R. A. Yokel, N. Yenugadhati, T. M. Wisniewski et al., Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts, Crit. Rev. Toxicol, vol.44, pp.1-80, 2014.

C. Vignal, P. Desreumaux, and M. Body-malapel, Gut: An underestimated target organ for Aluminum, vol.100, pp.75-84, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01935789

S. M. Saiyed and R. A. Yokel, Aluminium content of some foods and food products in the USA, with aluminium food additives, Food Addit. Contam, vol.22, pp.234-244, 2005.

D. Krewski, R. A. Yokel, E. Nieboer, D. Borchelt, J. Cohen et al., Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide, J. Toxicol. Environ. Health. B Crit. Rev, vol.10, pp.1-269, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00289661

I. Gehrke and A. Geiser, Somborn-Schulz, A. Innovations in nanotechnology for water treatment, Nanotechnol. Sci. Appl, vol.8, pp.1-17, 2015.

J. Zhao and V. Castranova, Toxicology of nanomaterials used in nanomedicine, J. Toxicol. Environ. Health B Crit. Rev, vol.14, pp.593-632, 2011.

A. Frey, M. R. Neutra, and F. A. Robey, Peptomer aluminum oxide nanoparticle conjugates as systemic and mucosal vaccine candidates: Synthesis and characterization of a conjugate derived from the C4 domain of HIV-1MN gp120, Bioconjug. Chem, vol.8, pp.424-433, 1997.

R. J. Narayan, S. P. Adiga, M. J. Pellin, L. A. Curtiss, A. J. Hryn et al., Atomic layer deposition-based functionalization of materials for medical and environmental health applications, Philos. Trans. R. Soc. A Math. Phys. Eng. Sci, vol.368, pp.2033-2064, 2010.

, JECFA Summary and Conclusions of the Sixty-Seventh Meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). Available online, 2020.

A. Balasubramanyam, N. Sailaja, M. Mahboob, M. F. Rahman, S. Misra et al., Evaluation of genotoxic effects of oral exposure to aluminum oxide nanomaterials in rat bone marrow, Mutat. Res, vol.676, pp.41-47, 2009.

E. J. Park, J. Sim, Y. Kim, B. S. Han, C. Yoon et al., A 13-week repeated-dose oral toxicity and bioaccumulation of aluminum oxide nanoparticles in mice, Arch. Toxicol, vol.89, pp.371-379, 2015.

R. Shrivastava, S. Raza, A. Yadav, P. Kushwaha, and S. J. Flora, Effects of sub-acute exposure to TiO2, ZnO and Al2O3 nanoparticles on oxidative stress and histological changes in mouse liver and brain, Drug Chem. Toxicol, vol.37, pp.336-347, 2014.

P. V. Prabhakar, U. A. Reddy, S. P. Singh, A. Balasubramanyam, M. F. Rahman et al., Oxidative stress induced by aluminum oxide nanomaterials after acute oral treatment in Wistar rats, J. Appl. Toxicol, vol.32, pp.436-445, 2012.

, Registration dossier Aluminum oxide, 2020.

A. Tsaousi, E. Jones, and C. P. Case, The in vitro genotoxicity of orthopaedic ceramic (Al2O3) and metal (CoCr alloy) particles, Mutat. Res, vol.697, pp.1-9, 2010.

S. Alarifi, D. Ali, and S. Alkahtani, Nanoalumina induces apoptosis by impairing antioxidant enzyme systems in human hepatocarcinoma cells, Int. J. Nanomed, vol.10, pp.3751-3760, 2015.

S. Rajiv, J. Jerobin, V. Saranya, M. Nainawat, A. Sharma et al., Comparative cytotoxicity and genotoxicity of cobalt (II, III) oxide, iron (III) oxide, silicon dioxide, and aluminum oxide nanoparticles on human lymphocytes in vitro, Hum. Exp. Toxicol, vol.35, pp.170-183, 2016.

D. Virgilio, A. L. Reigosa, M. Arnal, P. M. Fernandez-lorenzo-de-mele, and M. , Comparative study of the cytotoxic and genotoxic effects of titanium oxide and aluminium oxide nanoparticles in Chinese hamster ovary (CHO-K1) cells, J. Hazard. Mater, vol.177, pp.711-718, 2010.

P. D. Lima, D. S. Leite, M. C. Vasconcellos, B. C. Cavalcanti, R. A. Santos et al., Genotoxic effects of aluminum chloride in cultured human lymphocytes treated in different phases of cell cycle, Food Chem. Toxicol, vol.45, pp.1154-1159, 2007.

A. Lankoff, A. Banasik, A. Duma, E. Ochniak, H. Lisowska et al., A comet assay study reveals that aluminium induces DNA damage and inhibits the repair of radiation-induced lesions in human peripheral blood lymphocytes, Toxicol. Lett, vol.161, pp.27-36, 2006.

L. N. Paz, L. M. Moura, D. C. Feio, M. S. Cardoso, W. L. Ximenes et al., Evaluation of in vivo and in vitro toxicological and genotoxic potential of aluminum chloride, vol.175, pp.130-137, 2017.

N. B. Hartmann, K. A. Jensen, A. Baun, K. Rasmussen, H. Rauscher et al., Techniques and Protocols for Dispersing Nanoparticle Powders in Aqueous Media-Is there a Rationale for Harmonization?, J. Toxicol. Environ. Health B Crit. Rev, vol.18, pp.299-326, 2015.

K. A. Jensen, Y. Kembouche, E. Christiansen, N. R. Jacobsen, H. Wallin et al., Final Protocol for Producing Suitable Manufactured Nanomaterial Exposure Media. Web-Report. The Generic NANOGENOTOX Dispersion Protocol-Standard Operation Procedure (SOP), 2020.

H. Sieg, C. Kastner, B. Krause, T. Meyer, A. Burel et al., Impact of an Artificial Digestion Procedure on Aluminum-Containing Nanomaterials, vol.33, pp.10726-10735, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01617104

B. Krause, T. Meyer, H. Sieg, C. Kästner, P. Reichardt et al., Characterization of aluminum, aluminum oxide and titanium dioxide nanomaterials using a combination of methods for particle surface and size analysis, RSC Adv, vol.8, pp.14377-14388, 2018.
URL : https://hal.archives-ouvertes.fr/anses-01787430

, In Vivo Mammalian Alkaline Comet Assay, vol.489, 2016.

A. Tarantini, S. Huet, G. Jarry, R. Lanceleur, M. Poul et al., Genotoxicity of synthetic amorphous silica nanoparticles in rats following short-term exposure. Part 1: Oral route, Environ. Mol. Mutagen, vol.56, pp.218-227, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01099943

V. J. Mckelvey-martin, M. H. Green, P. Schmezer, B. L. Pool-zobel, M. P. De-meo et al., The single cell gel electrophoresis assay (comet assay): A European review, Mutat. Res, vol.288, pp.47-63, 1993.

A. Zeller, G. Duran-pacheco, and M. Guerard, An appraisal of critical effect sizes for the benchmark dose approach to assess dose-response relationships in genetic toxicology, Arch. Toxicol, vol.91, pp.3799-3807, 2017.

R. R. Tice, E. Agurell, D. Anderson, B. Burlinson, A. Hartmann et al., Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing, Environ. Mol. Mutagen, vol.35, pp.206-221, 2000.

, Mammalian Erythrocyte Micronucleus Test, vol.474, 2016.

Q. Zhang, H. Wang, C. Ge, J. Duncan, K. He et al., Alumina at 50 and 13 nm nanoparticle sizes have potential genotoxicity, J. Appl. Toxicol, vol.37, pp.1053-1064, 2017.

G. B. Akbaba and H. Turkez, Investigation of the Genotoxicity of Aluminum Oxide, beta-Tricalcium Phosphate, and Zinc Oxide Nanoparticles In Vitro, Int. J. Toxicol, vol.37, pp.216-222, 2018.

M. Hashimoto and S. Imazato, Cytotoxic and genotoxic characterization of aluminum and silicon oxide nanoparticles in macrophages, Dent. Mater, vol.31, pp.556-564, 2015.

P. Jalili, S. Huet, A. Burel, B. Krause, C. Fontana et al., Genotoxic impact of aluminum-containing nanomaterials in human intestinal and hepatic cells

D. J. Mckenna, M. Gallus, S. R. Mckeown, C. S. Downes, and V. J. Mckelvey-martin, Modification of the alkaline Comet assay to allow simultaneous evaluation of mitomycin C-induced DNA cross-link damage and repair of specific DNA sequences in RT4 cells, DNA Repair, vol.2, pp.879-890, 2003.

P. Chen, C. A. Sjogren, P. B. Larsen, and A. Schnittger, A multi-level response to DNA damage induced by aluminium, Plant J, vol.98, pp.479-491, 2019.

M. I. Yousef, T. F. Mutar, and M. A. Kamel, Hepato-renal toxicity of oral sub-chronic exposure to aluminum oxide and/or zinc oxide nanoparticles in rats, Toxicol. Rep, vol.6, pp.336-346, 2019.

I. A. Minigalieva, B. A. Katsnelson, L. I. Privalova, M. P. Sutunkova, V. B. Gurvich et al., Titanium (IV) and Silicon (IV) Oxide Nanoparticles and Its Alleviation with a Complex of Bioprotectors, Combined Subchronic Toxicity of Aluminum (III), vol.19, 2018.

G. M. Morsy, K. S. El-ala, and A. A. Ali, Studies on fate and toxicity of nanoalumina in male albino rats: Lethality, bioaccumulation and genotoxicity, Toxicol. Ind. Health, vol.32, pp.344-359, 2016.

E. Demir, H. Akca, F. Turna, S. Aksakal, D. Burgucu et al., Genotoxic and cell-transforming effects of titanium dioxide nanoparticles, Environ. Res, vol.136, pp.300-308, 2015.

C. Gao, M. Mortimer, M. Zhang, P. A. Holden, P. Cai et al., Impact of metal oxide nanoparticles on in vitro DNA amplification

S. A. Shah, G. H. Yoon, A. Ahmad, F. Ullah, F. U. Amin et al., Nanoscale-alumina induces oxidative stress and accelerates amyloid beta (A?) production in ICR female mice, Nanoscale, vol.7, pp.15225-15237, 2015.

E. G. Canli, G. Atli, and M. Canli, Response of the antioxidant enzymes of the erythrocyte and alterations in the serum biomarkers in rats following oral administration of nanoparticles, Environ. Toxicol. Pharmacol, vol.50, pp.145-150, 2017.

X. Li, C. Zhang, X. Zhang, S. Wang, Q. Meng et al., An acetyl-L-carnitine switch on mitochondrial dysfunction and rescue in the metabolomics study on aluminum oxide nanoparticles

A. Sliwinska, D. Kwiatkowski, P. Czarny, J. Milczarek, M. Toma et al., Genotoxicity and cytotoxicity of ZnO and Al2O3 nanoparticles, Toxicol. Mech. Methods, vol.25, pp.176-183, 2015.

G. M. Morsy, K. S. El-ala, and A. A. Ali, Studies on fate and toxicity of nanoalumina in male albino rats: Some haematological, biochemical and histological aspects, Toxicol. Ind. Health, vol.32, pp.634-655, 2016.

E. G. Canli, G. Atli, and M. Canli, Responses of biomarkers belonging to different metabolic systems of rats following oral administration of aluminium nanoparticle, Environ. Toxicol. Pharm, vol.69, pp.72-79, 2019.

E. Demir, D. Burgucu, F. Turna, S. Aksakal, and B. Kaya, Determination of TiO2, ZrO2, and Al2O3 nanoparticles on genotoxic responses in human peripheral blood lymphocytes and cultured embyronic kidney cells, J. Toxicol. Environ. Health A, vol.76, pp.990-1002, 2013.

I. M'rad, M. Jeljeli, N. Rihane, P. Hilber, M. Sakly et al., Aluminium oxide nanoparticles compromise spatial learning and memory performance in rats, Excli. J, vol.17, pp.200-210, 2018.

H. Turkez, M. I. Yousef, and F. Geyikoglu, Propolis prevents aluminium-induced genetic and hepatic damages in rat liver, Food Chem. Toxicol, vol.48, pp.2741-2746, 2010.

F. Geyikoglu, H. Turkez, T. O. Bakir, and M. Cicek, The genotoxic, hepatotoxic, nephrotoxic, haematotoxic and histopathological effects in rats after aluminium chronic intoxication, Toxicol. Ind. Health, vol.29, pp.780-791, 2013.

H. Turkez, F. Geyikoglu, and A. Tatar, Borax counteracts genotoxicity of aluminum in rat liver, Toxicol. Ind. Health, vol.29, pp.775-779, 2013.

Z. Cao, X. Geng, X. Jiang, X. Gao, K. Liu et al., Melatonin Attenuates AlCl3-Induced Apoptosis and Osteoblastic Differentiation Suppression by Inhibiting Oxidative Stress in MC3T3-E1 Cells, Biol. Trace Elem. Res, 2019.

C. S. Martinez, G. Vera, J. A. Ocio, F. M. Pecanha, D. V. Vassallo et al., Aluminum exposure for 60days at an equivalent human dietary level promotes peripheral dysfunction in rats, J. Inorg. Biochem, vol.181, pp.169-176, 2018.

X. Yang, K. Yu, H. Wang, H. Zhang, C. Bai et al., Bone impairment caused by AlCl3 is associated with activation of the JNK apoptotic pathway mediated by oxidative stress, Food Chem. Toxicol, vol.116, pp.307-314, 2018.

D. Cheng, X. Zhang, L. Xu, X. Li, L. Hou et al., Protective and prophylactic effects of chlorogenic acid on aluminum-induced acute hepatotoxicity and hematotoxicity in mice, Chem. Interact, vol.273, pp.125-132, 2017.

S. P. D'souza, K. K. Vijayalaxmi, and P. Naik, Assessment of genotoxicity of aluminium acetate in bone marrow, male germ cells and fetal liver cells of Swiss albino mice, Mutat. Res. Genet. Toxicol. Environ. Mutagen, vol.766, pp.16-22, 2014.

A. Banasik, A. Lankoff, A. Piskulak, K. Adamowska, H. Lisowska et al., Aluminum-induced micronuclei and apoptosis in human peripheral-blood lymphocytes treated during different phases of the cell cycle, Environ. Toxicol, vol.20, pp.402-406, 2005.

M. Villarini, A. Gambelunghe, D. Giustarini, M. V. Ambrosini, C. Fatigoni et al., No evidence of DNA damage by co-exposure to extremely low frequency magnetic fields and aluminum on neuroblastoma cell lines, Mutat. Res, vol.823, pp.11-21, 2017.