Effect of Nitrate, Ammonium and Urea on Growth and Pinnatoxin G Production of Vulcanodinium rugosum, Mar Drugs, vol.13, issue.9, pp.5642-56, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01259560
Toxin and Growth Responses of the Neurotoxic Dinoflagellate Vulcanodinium rugosum to Varying Temperature and Salinity, Toxins (Basel), vol.8, issue.5, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01923965
What are the main environmental factors driving the development of the neurotoxic dinoflagellate Vulcanodinium rugosum in a Mediterranean ecosystem (Ingril lagoon, France)?, Harmful Algae, vol.75, pp.75-86, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01824168
Effect of Nitrate, Ammonium and Urea on Growth and Pinnatoxin G Production of Vulcanodinium rugosum, Marine Drugs, vol.13, issue.9, p.5642, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01259560
Toxin and Growth Responses of the Neurotoxic Dinoflagellate Vulcanodinium rugosum to Varying Temperature and Salinity, Toxins (Basel), vol.8, issue.5, p.136, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01923965
Algal toxins and producers in the marine waters of Qatar, Toxicon, vol.122, pp.54-66, 2016. ,
Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail). 2017a. Valeurs toxicologiques de référence ,
Étude individuelle nationale des consommations alimentaires 3 (INCA 3). Avis de l'Anses et Rapport d'expertise collective, 2017. ,
Pinnatoxines en lien avec l'espèce Vulcanodinium rugosum (II) Partie 2 : Etudes sur la toxicité des pinnatoxines et d'extraits de Vulcanodinium rugosum, 2014. ,
Coupling the Torpedo Microplate-Receptor Binding Assay with Mass Spectrometry to Detect Cyclic Imine Neurotoxins, Analytical Chemistry, vol.84, issue.23, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-00769970
Total synthesis of pinnatoxins A and G and revision of the mode of action of pinnatoxin A, J Am Chem Soc, vol.133, issue.27, pp.10499-511, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00634136
Recurrent congenital arthrogryposis leading to a diagnosis of myasthenia gravis in an initially asymptomatic mother, Neuromuscul Disord, vol.5, issue.1, pp.59-65, 1995. ,
Ananlyse statistique et comparaison des résultats obtenus par deux méthodes d'analyse : les bio-essais sur souris et les analyses chimiques par CL-SM/SM, 2009. ,
Pyramidal neurons of the rat cerebral cortex, immunoreactive to nicotinic acetylcholine receptors, project mainly to subcortical targets, Journal of Comparative Neurology, vol.320, issue.1, pp.62-68, 1992. ,
, Etude des Consommations ALimentaires de produits de la mer et Imprégnation aux éléments traces, PolluantS et Oméga 3.). 2006. 162 p. J.C. Leblanc (Coordinateur). Afssa/Ministère de l'Agriculture et de la pêche
Isolation and structure of pinnatoxin D, a new shellfish poison from the Okinawan bivalve Pinna muricata, Tetrahedron Letters, vol.37, issue.23, pp.4027-4030, 1996. ,
Biodiversity and Adaptive Mechanisms in Brackish Water Fauna, Marine Pollution Bulletin, vol.40, issue.1, pp.173-176, 2000. ,
Proliferation of the toxic dinoflagellate Ostreopsis cf. ovata in relation to depth, biotic substrate and environmental factors in the North West Mediterranean Sea, Harmful Algae, vol.24, pp.32-44, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00926994
, Anses ? rapport d'expertise collective Saisine « 2016-SA-0013 » Pinnatoxines, pp.86-106
The alpha 5 gene product assembles with multiple acetylcholine receptor subunits to form distinctive receptor subtypes in brain, Neuron, vol.9, issue.4, pp.679-91, 1992. ,
Understanding the Bases of Function and Modulation of alpha7 Nicotinic Receptors: Implications for Drug Discovery, Mol Pharmacol, vol.90, issue.3, pp.288-99, 2016. ,
The value of the world's ecosystem services and natural capital, Ecological Economics, vol.25, issue.1, pp.20-22, 1998. ,
Pinnatoxins block skeletal neuromuscular junction activity and affect embryo development, Toxicon, vol.91, pp.175-176, 2014. ,
DOI : 10.1016/j.toxicon.2014.08.036
The marine cytotoxin portimine is a potent and selective inducer of apoptosis, Apoptosis, vol.21, issue.12, pp.1447-1452, 2016. ,
Tectus niloticus (Tegulidae, gastropod) as a novel vector of ciguatera poisoning: Detection of pacific ciguatoxins in toxic samples from nuku hiva island (french polynesia), Toxins (Basel), issue.1, p.10, 2018. ,
, DGAL (Direction générale de l'alimentation), 2009.
Arthrogryposis multiplex in a newborn of a myasthenic mother--case report and literature, Neuromuscul Disord, vol.3, issue.4, pp.335-344, 1993. ,
Properties of nicotinic receptors underlying Renshaw cell excitation by ?-motor neurons in neonatal rat spinal cord, Journal of Neurophysiology, vol.87, issue.6, pp.3117-3125, 2002. ,
Scientific Opinion on marine biotoxins in shellfish -Cyclic imines (spirolides, gymnodimines, pinnatoxins and pteriatoxins), EFSA Journal, vol.8, issue.6, p.1628, 2010. ,
, Statement on further elaboration of the consumption figure of 400 g shellfish meat on the basis of new consumption data, EFSA (European Food Safety Authority), vol.8, p.1706, 2010.
The predisposition to inspiratory upper airway collapse during partial neuromuscular blockade, Am J Respir Crit Care Med, vol.175, issue.1, pp.9-15, 2007. ,
Myasthenia gravis: diagnostic mimics, Semin Neurol, vol.24, issue.2, pp.141-148, 2004. ,
DOI : 10.1055/s-2004-830903
MRI and clinical studies of facial and bulbar muscle involvement in MuSK antibody-associated myasthenia gravis, Brain, vol.129, pp.1481-92, 2006. ,
Functional architecture of the nicotinic acetylcholine receptor: from electric organ to brain, Annu Rev Pharmacol Toxicol, vol.31, pp.37-72, 1991. ,
Confirmation of pinnatoxins and spirolides in shellfish and passive samplers from Catalonia (Spain) by liquid chromatography coupled with triple quadrupole and high-resolution hybrid tandem mass spectrometry, Mar Drugs, vol.12, issue.6, pp.3706-3738, 2014. ,
Identification of the harmful dinoflagellate Vulcanodinium rugosum recovered from a ballast tank of a globally traveled ship in, Harmful Algae, vol.39, pp.202-209, 2014. ,
Seafood and Freshwater Toxins: Pharmacology, Physiology, and Detection, Third Edition, Journal of Aquatic Food Product Technology, vol.24, issue.4, pp.411-414, 2015. ,
DOI : 10.1080/10498850.2015.1024964
Cytotoxicity, fractionation and dereplication of extracts of the dinoflagellate Vulcanodinium rugosum, Mar Drugs, vol.11, issue.9, pp.3350-71, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00862461
, Anses ? rapport d'expertise collective Saisine « 2016-SA-0013, vol.87, 2019.
Liquid chromatography-tandem mass spectrometry method for the detection of marine lipophilic toxins under alkaline conditions, J Chromatogr A, vol.1216, issue.9, pp.1421-1451, 2009. ,
Brain nicotinic acetylcholine receptors: native subtypes and their relevance, Trends Pharmacol Sci, vol.27, issue.9, pp.482-91, 2006. ,
DOI : 10.1016/j.tips.2006.07.004
Synthesis of a Functionalized 7,6-Bicyclic Spiroimine Ring Fragment of the Spirolides, Org Lett, vol.12, issue.22, pp.5226-5229, 2010. ,
, Pharmacologie des curares. EMC -Anesthésie-Réanimation, vol.14, issue.3, pp.1-25, 2017.
, International Publication Number WO 2014/189393 A3, 2014.
Extraction of Lipid-Soluble Marine Biotoxins, J AOAC Int, vol.78, issue.2, 1995. ,
Dopamine efflux from striatum after chronic nicotine: evidence for autoreceptor desensitization, J Neurochem, vol.59, issue.1, pp.48-54, 1992. ,
DOI : 10.1111/j.1471-4159.1992.tb08874.x
Modulation of acetylcholine receptor in rat diaphragm by antireceptor sera, Nature, vol.6, issue.5666, pp.65-73, 1978. ,
Marine algal pinnatoxins E and F cause neuromuscular block in an in vitro hemidiaphragm preparation, Toxicon, vol.58, issue.8, pp.693-702, 2011. ,
Neuromuscular blocking activity of pinnatoxins E, F and G, Toxicon, vol.76, pp.214-234, 2013. ,
Morphology and life stages of the potentially pinnatoxin-producing thecate dinoflagellate Vulcanodinium rugosum from the tropical Mexican Pacific, Botanica Marina, vol.56, issue.5-6, pp.535-540, 2013. ,
Pinnatoxin G is responsible for atypical toxicity in mussels (Mytilus galloprovincialis) and clams (Venerupis decussata) from Ingril, a French Mediterranean lagoon, Toxicon, vol.75, pp.16-26, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00919909
Three Rs Approaches in Marine Biotoxin Testing. The Report and Recommendations of a joint ECVAM/DG SANCO Workshop (ECVAM Workshop 54), Altern Lab Anim, vol.34, issue.2, pp.193-224, 2006. ,
Isolation and structure of prorocentrolide B, a fast-acting toxin from Prorocentrum maculosum, J Nat Prod, vol.59, issue.11, 1996. ,
Pinnatoxines en lien avec l'espèce Vulcanodinium rugosum, Référence Ifremer: 11/1219401/NYF, vol.144, 2012. ,
Contamination des mollusques bivalves par Vulcanodinium rugosum, producteur de pinnatoxines, p.60, 2014. ,
Acetylcholine in human muscle, Proc R Soc Lond B Biol Sci, vol.16, pp.475-80, 1109. ,
Stability of cyclic imine toxins: interconversion of pinnatoxin amino ketone and pinnatoxin A in aqueous media, J Org Chem, vol.77, issue.22, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-00756265
A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data, Regul Toxicol Pharmacol, vol.25, issue.1, pp.1-5, 1997. ,
Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei, J Neurosci, vol.21, issue.5, pp.1452-63, 2001. ,
Pharmacologie des cibles à la thérapeutique, 2014. ,
Determination of multiple toxins in whelk and clam samples collected from the Chukchi and Bering seas, Toxicon, vol.109, pp.84-93, 2016. ,
How the autoimmune response to acetylcholine receptor impairs neuromuscular transmission in myasthenia gravis and its animal model, Fed Proc, vol.37, issue.14, pp.2828-2858, 1978. ,
Anticholinergic toxicity associated with the ingestion of lupini beans, Am J Emerg Med, vol.25, issue.2, pp.215-222, 2007. ,
Spiro-prorocentrimine, a novel macrocyclic lactone from a benthic Prorocentrum sp of Taiwan, Tetrahedron Letters, vol.42, issue.9, pp.1713-1716, 2001. ,
In situ passive solid-phase adsorption of micro-algal biotoxins as a monitoring tool, Curr Opin Biotechnol, vol.21, issue.3, pp.326-357, 2010. ,
Benthic dinoflagellate toxins in two warmtemperate estuaries: Rangaunu and Parengarenga Harbours, Harmful Algae, vol.10, issue.6, pp.559-566, 2011. ,
Solid phase adsorption toxin tracking (SPATT): a new monitoring tool that simulates the biotoxin contamination of filter feeding bivalves, Toxicon, vol.44, issue.8, pp.901-919, 2004. ,
Identification of pinnatoxins and discovery of their fatty acid ester metabolites in mussels ( Mytilus edulis ) from eastern Canada, J Agric Food Chem, vol.60, issue.6, pp.1437-1483, 2012. ,
Liquid chromatography/mass spectrometry of domoic acid and lipophilic shellfish toxins with selected reaction monitoring and optional confirmation by library searching of product ion spectra, J AOAC Int, vol.97, issue.2, pp.316-340, 2014. ,
Identification of Pinnatoxins and Discovery of Their Fatty Acid Ester Metabolites in Mussels (Mytilus edulis) from Eastern Canada, Journal of Agricultural and Food Chemistry, vol.60, issue.6, pp.1437-1446, 2012. ,
Assessment of emerging biotoxins (pinnatoxin G and spirolides) at Europe's first marine reserve: Lough Hyne, Toxicon, vol.108, pp.202-211, 2015. ,
Total synthesis of pinnatoxin A", Journal of the American Chemical Society, vol.120, issue.30, pp.7647-7648, 1998. ,
New perspectives on biotoxin detection in Rangaunu Harbour, New Zealand arising from the discovery of pinnatoxins, Harmful Algae, vol.13, pp.34-39, 2012. ,
Potential therapeutic uses of mecamylamine and its stereoisomers, Pharmacol Biochem Behav, vol.108, pp.28-43, 2013. ,
DOI : 10.1016/j.pbb.2013.04.005
URL : http://europepmc.org/articles/pmc3690754?pdf=render
Cyclic Imines: An Insight into this Emerging Group of Bioactive Marine Toxins, In Phycotoxins Chemistry and Biochemistry, p.319, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-00106909
Cyclic imine toxins from dinoflagellates: a growing family of potent antagonists of the nicotinic acetylcholine receptors, J Neurochem, vol.142, pp.41-51, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01661784
Spirolides and Cyclic Imines: Toxicological Profile, Marine and Freshwater Toxins, pp.193-217, 2016. ,
Summer bloom of Vulcanodinium rugosum in Cienfuegos Bay (Cuba) associated to dermatitis in swimmers, International Conference on Harmful Algae (ICHA), pp.21-26, 2018. ,
Protein phosphatase inhibition assay adapted for determination of total DSP in contaminated mussels, Toxicon, vol.39, issue.2-3, pp.383-90, 2001. ,
, Anses ? rapport d'expertise collective Saisine « 2016-SA-0013 » Pinnatoxines, pp.89-106
Toxicology of cyclic imines: gymnodimine, spirolides, pinnatoxins,pteriatoxins, prorocentrolide, spiro-prorocentrimine and symbioimines, Seafood and freshwater toxinsPharmacology, 2008. ,
Acute toxicity of pinnatoxins E, F and G to mice, Toxicon, vol.60, issue.6, pp.995-999, 2012. ,
Vulcanodinium rugosum gen. nov., sp. nov. (dinophyceae): A new marine dino-flagellate from the french mediterranean coast, Cryptogamie, Algologie, vol.32, issue.1, pp.3-18, 2011. ,
Lambert-Eaton myasthenic syndrome, Rev Neurol (Paris), vol.160, issue.2, pp.177-80, 2004. ,
The flux of carbon, nitrogen and phosphorus between coastal lagoons and offshore waters, 1981. ,
Anagyrine-induced red cell aplasia, vascular anomaly,and skeletal dysplasia, J Pediatr, vol.111, issue.1, pp.87-96, 1987. ,
DOI : 10.1016/s0022-3476(87)80349-9
Alexandrium catenella (Dinophyceae), a toxic ribotype expanding in the NW Mediterranean Sea, Marine Biology, vol.148, issue.1, pp.13-23, 2005. ,
Lupines, poison-hemlock and Nicotiana spp: toxicity and teratogenicity in livestock, J Nat Toxins, vol.8, issue.1, pp.117-151, 1999. ,
The corrugator supercilii, not the orbicularis oculi, reflects rocuronium neuromuscular blockade at the laryngeal adductor muscles, Anesthesiology, vol.95, issue.1, pp.96-101, 2001. ,
, Programme des Nations Unies pour l'environnement), PNUE, 2007.
Nicotinic receptors in circuit excitability and epilepsy, J Neurobiol, vol.53, issue.4, pp.580-589, 2002. ,
DOI : 10.1002/neu.10152
URL : https://onlinelibrary.wiley.com/doi/pdf/10.1002/neu.10152
Occurrence of cyclic imines in European commercial seafood and consumers risk assessment, Environ Res, vol.161, pp.392-398, 2018. ,
Production of pinnatoxins E, F and G by scrippsielloid dinoflagellates isolated from Franklin Harbour, South Australia, New Zealand Journal of Marine and Freshwater Research, vol.45, issue.4, pp.703-709, 2011. ,
Production of pinnatoxins by a peridinoid dinoflagellate isolated from Northland, Harmful Algae, vol.9, issue.4, pp.384-389, 2010. ,
Colorimetric microtiter plate receptor-binding assay for the detection of freshwater and marine neurotoxins targeting the nicotinic acetylcholine receptors, Toxicon, vol.91, pp.45-56, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01165541
Pinnatoxins and spirolides in Norwegian blue mussels and seawater, Toxicon, vol.58, issue.8, pp.700-711, 2011. ,
DOI : 10.1016/j.toxicon.2011.08.008
Does this patient have myasthenia gravis?, JAMA, vol.20, issue.15, pp.1906-1920, 2005. ,
DOI : 10.1001/jama.293.15.1906
Isolation, structural determination and acute toxicity of pinnatoxins E, F and G, J Agric Food Chem, vol.58, issue.10, pp.6532-6574, 2010. ,
Pinnatoxin H: A new pinnatoxin analogue from a South China Sea Vulcanodinium rugosum isolate, Tetrahedron Letters, vol.55, issue.40, pp.5508-5510, 2014. ,
DOI : 10.1016/j.tetlet.2014.08.056
Portimine: A bioactive metabolite from the benthic dinoflagellate Vulcanodinium rugosum, Tetrahedron Letters, vol.54, issue.35, pp.4705-4707, 2013. ,
, Anses ? rapport d'expertise collective Saisine
Disorders of neuromuscular transmission due to natural environmental toxins, J Neurol Sci, vol.107, issue.1, pp.1-13, 1992. ,
DOI : 10.1016/0022-510x(92)90202-v
Chemical and toxicological investigation of the toxic dinoflagellate, Karenia brevisulcata, 2012. ,
A dinoflagellate producer of pinnatoxin G, isolated from sub-tropical Japanese waters, Harmful Algae, vol.10, issue.6, pp.702-705, 2011. ,
Cholinergic-mediated coordination of rhythmic sympathetic and motor activities in the newborn rat spinal cord, PLoS biology, vol.16, issue.7, 2018. ,
The repetitive and expanding occurrence of a green bloom-forming dinoflagellate (dynophyceae) on the coasts of France, Cryptogamie, Algologie, vol.13, issue.1, pp.1-13, 1992. ,
Synthesis and biology of cyclic imine toxins, an emerging class of potent, globally distributed marine toxins, Nat Prod Rep, vol.32, issue.3, pp.411-435, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01178830
Structural determination of pteriatoxins A, B and C, extremely potent toxins from the bivalve Pteria penguin, Tetrahedron Letters, vol.42, issue.20, pp.478-484, 2001. ,
Prorocentrolide, a toxic nitrogenous macrocycle from a marine dinoflagellate, Prorocentrum lima, J Am Chem Soc, vol.110, issue.23, pp.7876-7877, 1988. ,
DOI : 10.1021/ja00231a048
Pinnatoxin-aa toxic amphoteric macrocycle from the Okinawan bivalve Pinna muricata, J Am Chem Soc, vol.117, issue.3, pp.1155-1156, 1995. ,
DOI : 10.1021/ja00108a043
Determination of lipophilic toxins by LC/MS/MS: single-laboratory validation, J AOAC Int, vol.94, issue.3, pp.909-931, 2011. ,
Anti-acetylcholine receptor antibodies in D-penicillamineassociated myasthenia gravis, Lancet, vol.10, issue.8076, p.1254, 1978. ,
DOI : 10.1016/s0140-6736(78)92481-9
Serological and experimental studies in different forms of myasthenia gravis, Ann N Y Acad Sci, vol.1413, issue.1, p.130, 1417. ,
, Allerg Immunol, vol.20, issue.9, pp.344-349, 1988.
Occurrence of a New Type of Shellfish Poisoning in the Tohoku District, Nippon Suisan Gakkaishi (Japanese Edition), vol.44, issue.11, pp.1249-1255, 1978. ,
Diarrhetic Shellfish Poisoning, Seafood Toxins, pp.207-214, 1984. ,
Mecamylamine: new therapeutic uses and toxicity/risk profile, Clin Ther, vol.23, issue.4, pp.532-65, 2001. ,
DOI : 10.1016/s0149-2918(01)80059-x
Extended evaluation of polymeric and lipophilic sorbents for passive sampling of marine toxins, Toxicon, vol.91, pp.57-68, 2014. ,
High resolution mass spectrometry for quantitative analysis and untargeted screening of algal toxins in mussels and passive samplers, J Chromatogr A, vol.1416, pp.10-21, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01664180
The first report of Vulcanodinium rugosum (Dinophyceae) from the South China Sea with a focus on the life cycle, New Zealand Journal of Marine and Freshwater Research, vol.46, issue.4, pp.511-521, 2012. ,
The Isolation and Bioactivities of Pinnatoxin, Chinese Journal of Marine Drugs Zhongguo Haiyang Yaowu, issue.9, pp.33-35, 1990. ,