Dye residues in aquaculture products: Targeted and metabolomics mass spectrometric approaches to track their abuse

E. Dubreil; S. Mompelat; V. Kromer; Y. Guitton; M. Danion; T. Morin; D. Hurtaud-Pessel; E. Verdon

Dye residues in aquaculture products: Targeted and metabolomics mass spectrometric approaches to track their abuse

E. Dubreil ¹ S. Mompelat ¹ V. Kromer ¹ Y. Guitton ² M. Danion ³ T. Morin ³ D. Hurtaud-Pessel ¹ E. Verdon ¹

1 Laboratoire de Fougères, Bâtiment Bioagropolis

2 LABERCA - Laboratoire d'étude des Résidus et Contaminants dans les Aliments

Abstract : The aim of the study was to initiate an exhaustive strategy of control by implementing both targeted and non-targeted metabolomics approaches. A LC-MS/MS method including an oxidative step for most of dyes was developed and validated to target the analysis of 14 residues belonging to different families of dyes. The method was suitable for the quantitative confirmation of 13 dyes at low ppb levels. The metabolomics approach objective was to compare fingerprints between farmed fish treated with malachite green and farmed fish treated with victoria pure blue bo. Analytical information on modifications in the metabolome of muscle, liver and plasma was exploited by HRMS following by multivariate statistics and revealed some direct or endogenous metabolites among relevant mass features contributing to the constructed models. These two approaches, either appropriate biomarkers either enlarged targeted dyes are explored concomitantly to help improving the strategy for tracking new illegal practices in aquaculture.

Keywords : aquaculture dye analysis mass spectrometry metabolomic malachite green Victoria pure blue bo food safety

Document type :

Journal articles

Domain :

Chemical Sciences / Analytical chemistry

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https://hal-anses.archives-ouvertes.fr/anses-02156779
Contributor : Emmanuelle Chiffoleau <>
Submitted on : Friday, June 14, 2019 - 4:29:59 PM
Last modification on : Tuesday, October 22, 2019 - 9:02:03 AM

Dye residues in aquaculture products: Targeted and metabolomics mass spectrometric approaches to track their abuse

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Dye residues in aquaculture products: Targeted and metabolomics mass spectrometric approaches to track their abuse

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