Comparison of different maximum safe levels in fortified foods and supplements using a probabilistic risk assessment approach

Ariane Dufour 1, * Sandrine Wetzler 2 Mathilde Touvier 3 Sandrine Lioret 2 Jennifer Gioda 2 Lionel Lafay 2 Carine Dubuisson 2 Gloria Calamassi-Tran 2 Esther Kalonji 2 Irène Margaritis 2 Jean-Luc Volatier 1
* Corresponding author
1 DER - Direction de l'Evaluation des Risques
2 UERN - Unité d'évaluation des risques nutritionnels [ANSES, Maisons-Alfort]
ANSES - Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail
3 UREN - Unité de Recherche en Epidémiologie Nutritionnelle
Abstract : Different European institutions have developed mathematical models to propose maximum safe levels either for fortified foods or for dietary supplements. The objective of the present study was to compare and check the safety of these different maximum safe levels (MSL) by using a probabilistic risk assessment approach. The potential maximum nutritional intakes were estimated by taking into account all sources of intakes (base diet, fortified foods and dietary supplements) and compared with the tolerable upper intake levels for vitamins and minerals. This approach simulated the consequences of both food fortification and supplementation in terms of food safety. Different scenarios were tested. They are the result of the combination of several MSL obtained using the previous models. The study was based on the second French Individual and National Study on Food Consumption performed in 2006–7, matched with the French food nutritional composition database. The analyses were based on a sample of 1918 adults aged 18–79 years. Some MSL in fortified foods and dietary supplements obtained independently were protective enough, although some others could lead to nutritional intakes above the tolerable upper intake levels. The simulation showed that it is crucial to consider the inter-individual variability of fortified food intakes when setting MSL for foods and supplements. The risk assessment approach developed here by integrating the MSL for fortified foods and dietary supplements is useful for ensuring consumer protection. It may be subsequently used to test any other MSL for vitamins and minerals proposed in the future.
Keywords : Fortified foods Dietary supplements Minerals Vitamins Tolerable upper intake levels Simulations
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Journal articles
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https://hal-anses.archives-ouvertes.fr/anses-01875214
Contributor : Carine Dubuisson <>
Submitted on : Monday, September 17, 2018 - 10:22:01 AM
Last modification on : Tuesday, October 22, 2019 - 9:20:05 AM

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Ariane Dufour, Sandrine Wetzler, Mathilde Touvier, Sandrine Lioret, Jennifer Gioda, et al.. Comparison of different maximum safe levels in fortified foods and supplements using a probabilistic risk assessment approach. British Journal of Nutrition, Cambridge University Press (CUP), 2010, 104 (12), pp.1848 - 1857. ⟨10.1017/S0007114510002862⟩. ⟨anses-01875214⟩

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