??H2AX and p53 responses in TK6 cells discriminate promutagens and nongenotoxicants in the presence of rat liver S9, Environmental and Molecular Mutagenesis, vol.227, issue.7, pp.546-558, 2016. ,
DOI : 10.1016/0165-7992(89)90107-3
Evaluation of a multi-endpoint assay in rats, combining the bone-marrow micronucleus test, the Comet assay and the flow-cytometric peripheral blood micronucleus test, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.722, issue.1, pp.7-19, 2011. ,
DOI : 10.1016/j.mrgentox.2011.02.009
Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay. Environmental and Mololecular Mutagenesis, pp.146-161, 2017. ,
, Vivo Comet Assay Workgroup, part of the Fourth International Workgroup on Genotoxicity Testing Fourth International Workgroup on Genotoxicity testing: results of the in vivo Comet assay workgroup. Mutation Reseach, pp.31-35, 2007.
Evaluation of beauvericin genotoxicity with the chromosomal aberrations, sister-chromatid exchanges and micronucleus assays, Ecotoxicology and Environmental Safety, vol.73, issue.7, pp.1553-1557, 2010. ,
DOI : 10.1016/j.ecoenv.2010.07.036
When pigs fly: Immunomagnetic separation facilitates rapid determination of Pig-a mutant frequency by flow cytometric analysis, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.721, issue.2, pp.163-170, 2011. ,
DOI : 10.1016/j.mrgentox.2011.01.009
Oxidative stress and DNA interactions are not involved in Enniatin- and Beauvericin-mediated apoptosis induction, Molecular Nutrition & Food Research, vol.5, issue.9, pp.1112-1122, 2009. ,
DOI : 10.1016/j.mrfmmm.2007.03.006
EFSA Panel on Contaminants in the Food Chain), 2014. Scientific Opinion on the risks to human and animal health related to the presence of beauvericin and enniatins in food and feed, EFSA Journal, vol.12, issue.8 ,
HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.534, issue.1-2, pp.65-75, 2003. ,
DOI : 10.1016/S1383-5718(02)00249-8
Reactive oxygen species induced by beauvericin, patulin and zearalenone in CHO-K1 cells, Toxicology in Vitro, vol.23, issue.8, pp.1504-1509, 2009. ,
DOI : 10.1016/j.tiv.2009.07.009
The early stages of follicular development: activation of primordial follicles and growth of preantral follicles, Animal Reproduction Science, vol.78, issue.3-4, pp.135-163, 2003. ,
DOI : 10.1016/S0378-4320(03)00088-5
Evaluation of Beauvericin Toxicity with the Bacterial Bioluminescence Assay and the Ames Mutagenicity Bioassay, Journal of Food Science, vol.44, issue.3, pp.1938-1941, 2003. ,
DOI : 10.1016/0014-4827(91)90477-C
Enniatin B-induced cell death and inflammatory responses in RAW 267.4 murine macrophages, Toxicology and Applied Pharmacology, vol.261, issue.1, pp.74-87, 2012. ,
DOI : 10.1016/j.taap.2012.03.014
URL : https://hal.archives-ouvertes.fr/inserm-00871698
Characterisation of an in vivo Pig-a gene mutation assay for use in regulatory toxicology studies, Mutagenesis, vol.55, issue.3, pp.359-63, 2015. ,
DOI : 10.1002/em.21846
The in vivo Pig-a Toxicity of beauvericin and enniatin B www, p.1406, 2015. ,
, this task has been carried out exclusively by the authors in the context of a grant agreement between the European Food Safety Authority and the authors. The present document is published complying with the transparency principle to which the Authority is subject. It cannot be considered as an output adopted by the Authority. The European Food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors, assay: A report of the International Workshop On Genotoxicity Testing (IWGT) Workgroup. Mutation Research -Genetic Toxicology and Environmental Mutagenesis, pp.23-35, 2002.
Evaluation of the Pig-a, micronucleus, and comet assay endpoints in a 28-day study with ethyl methanesulfonate. Environmental and Mololecular Mutagenesis, pp.492-499, 2014. ,
In vivo erythrocyte micronucleus assay III. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion of non-hematopoietic target cells and a single dose-level limit test, In Vivo Micronucleus Assay Working Group, IWGT Mutation Research, vol.62, pp.10-30, 2007. ,
Estrogen increases the severity of anaphylaxis in female mice through enhanced endothelial nitric oxide synthase expression and nitric oxide production, Journal of Allergy and Clinical Immunology, vol.135, issue.3, pp.729-765, 2014. ,
DOI : 10.1016/j.jaci.2014.11.003
Evaluation of immunologic effect of Enniatin A and quantitative determination in feces, urine and serum on treated Wistar rats, Toxicon, vol.87, pp.45-53, 2014. ,
DOI : 10.1016/j.toxicon.2014.05.005
Recent Advances in In Vivo Genotoxicity Testing: Prediction of Carcinogenic Potential Using Comet and Micronucleus Assay in Animal Models, Journal of Cancer Prevention, vol.18, issue.4, pp.277-288, 2013. ,
DOI : 10.1016/0027-5107(95)00169-7
Genotoxicity of fumonisin B1, beauvericin and ochratoxin A in porcine kidney PK15 cells: effects of individual and combined treatment, Croatica Chemica Acta, vol.81, pp.139-146, 2008. ,
Beauvericin and ochratoxin A genotoxicity evaluated using the alkaline comet assay: single and combined genotoxic action, Archives of Toxicology, vol.39, issue.8, pp.641-650, 2010. ,
DOI : 10.1590/S0100-879X2006001200006
Complementarity of phosphorylated histones H2AX and H3 quantification in different cell lines for genotoxicity screening, Archives of Toxicology, vol.33, issue.8, 1983. ,
DOI : 10.1002/jat.2745
URL : https://hal.archives-ouvertes.fr/hal-01604521
Mechanisms of beauvericin toxicity and antioxidant cellular defense, Toxicology Letters, vol.246, pp.28-34, 2016. ,
DOI : 10.1016/j.toxlet.2016.01.013
Effects of the food contaminant semicarbazide following oral administration in juvenile Sprague???Dawley rats, Food and Chemical Toxicology, vol.47, issue.2, pp.472-479, 2009. ,
DOI : 10.1016/j.fct.2008.12.003
Accumulation and persistence of Pig-A mutant peripheral red blood cells following treatment of rats with single and split doses of N-ethyl-N-nitrosourea, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.677, issue.1-2, pp.86-92, 2009. ,
DOI : 10.1016/j.mrgentox.2009.05.014
Hypolipemics containing beauvericin as acylcoenzyme A cholesterol acyltransferase inhibitor, 1991. ,
Mouse tissue distribution and persistence of the food-born fusariotoxins Enniatin B and Beauvericin, Toxicology Letters, vol.247, pp.35-44, 2016. ,
DOI : 10.1016/j.toxlet.2016.02.008
DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139, Journal of Biological Chemistry, vol.337, issue.10, pp.5858-5868, 1998. ,
DOI : 10.1007/BF00274682
URL : http://www.jbc.org/content/273/10/5858.full.pdf
, , p.1406, 2010.
, this task has been carried out exclusively by the authors in the context of a grant agreement between the European Food Safety Authority and the authors. The present document is published complying with the transparency principle to which the Authority is subject. It cannot be considered as an output adopted by the Authority. The European Food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors. compounds in the rat-liver Comet assay integrated into 2-and 4-week repeat-dose studies, Regulation Mutation Research, vol.36, issue.702, pp.40-69, 2002.
Qualitative and Quantitative Analysis of Nonneoplastic Lesions in Toxicology Studies, Toxicologic Pathology, vol.2, issue.1, pp.93-96, 2002. ,
DOI : 10.1007/978-3-642-66292-8_2
General Background on the Hypothalamic-Pituitary-Thyroid (HPT) Axis, Critical Reviews in Toxicology, vol.16, issue.10, pp.11-53, 2007. ,
DOI : 10.1111/j.1365-2826.2004.01243.x
, Toxicity of beauvericin and enniatin B www.efsa.europa.eu/publications 181 EFSA Supporting publication, p.1406, 2018.
, this task has been carried out exclusively by the authors in the context of a grant agreement between the European Food Safety Authority and the authors. The present document is published complying with the transparency principle to which the Authority is subject. It cannot be considered as an output adopted by the Authority. The European Food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, Regulation (EC) No, vol.36, issue.178, 2002.