Bioassay Use in the Field of Toxic Cyanobacteria

Luděk Bláha 1 Ana Maria Valérie Fessard 2 Daniel Gutierrez-Praena Angeles Jos Benjamin Marie 3 James S Metcalf 4 Silvia Pichardo Maria Puerto Andrea Torokne Gabor Vasas Bojana Zegura
1 Masaryk University
2 ANSES - ANSES - Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail
3 MCAM - Molécules de Communication et Adaptation des Micro-organismes (MCAM)
4 Institute for Ethnomedicine
Abstract : Numerous assessment tools based on biological units (i.e. bioassays) have been developed to complement physicochemical or immunochemical methods. Bioassays provide complex information on the overall toxic potencies or biological activities of cyanobacterial samples including isolated cyanotoxins as well as natural blooms. The present chapter provides rationale beyond the use of bioassays and shows key examples for the assessment of toxic cyanobacteria covering both the toxicology (or more specifically toxinology for natural toxins) and ecotoxicology arenas for all levels of biological organization (from in vitro to in vivo, from plants to animals). At the present time, bioassays for potential use in routine monitoring need further research and validation, and there is no clear agreement among scientists on the list of recommended bioassays. Nevertheless, bioassays play an important role in the primary screening of cyanobacteria for toxic compounds and for their detection under specific situations such as limited access to advanced instrumental analytical equipment or indications of toxic metabolites other than (or in addition to) the known cyanotoxins.
Keywords : bioassay toxicity genotoxicity ecotoxicitytoxin cyanobacteria
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Book sections
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https://hal-anses.archives-ouvertes.fr/anses-01637568
Contributor : Emmanuelle Chiffoleau <>
Submitted on : Friday, November 17, 2017 - 4:12:53 PM
Last modification on : Tuesday, February 19, 2019 - 3:14:07 PM

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Luděk Bláha, Ana Maria, Valérie Fessard, Daniel Gutierrez-Praena, Angeles Jos, et al.. Bioassay Use in the Field of Toxic Cyanobacteria. Wiley. Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis, 27, pp.272-279, 2016, 9781119068761. ⟨10.1002/9781119068761.ch27⟩. ⟨anses-01637568⟩

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