Lack of experimental evidence to support mcr-1- positive escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets

Alexis Viel; Jérôme Henri; Agnès Perrin-Guyomard; Julian Laroche; William Couet; Nicolas Grégoire; Michel Laurentie

doi:10.1016/j.ijantimicag.2017.04.013

Journal articles

Lack of experimental evidence to support mcr-1- positive escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets

Alexis Viel ^{1, 2, 3} Jérôme Henri ¹ Agnès Perrin-Guyomard ¹ Julian Laroche ^{2, 4} William Couet ^{2, 4, 3} Nicolas Grégoire ^{2, 3} Michel Laurentie ¹

1 ANSES - Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail

2 PHAR - Pharmacologie des anti-infectieux

3 Université de Poitiers

4 CHU Poitiers - Centre hospitalier universitaire de Poitiers

Abstract : In this study, we assessed the selective effect of colistin orally administered to healthy weaned piglets harbouring an intestinal mcr-1-positive Escherichia coli strain. Maximum recommended dose and a higher dose often used in European pig farms were given by gavage. No selection of the mcr-1-positive strain was observed in our controlled conditions whatever the dose. Further investigations in real farming conditions seem necessary.

Keywords : oral administration colistin piglet veterinary drug efficacity MCR-1

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Journal articles

Domain :

Life Sciences [q-bio] / Pharmaceutical sciences / Medication

Life Sciences [q-bio] / Animal biology / Veterinary medicine and animal Health

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Lack of experimental evidence to support mcr-1- positive escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets

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