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Lack of experimental evidence to support mcr-1- positive escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets

Alexis Viel 1, 2, 3 Jérôme Henri 1 Agnès Perrin-Guyomard 1 Julian Laroche 2, 4 William Couet 2, 4, 3 Nicolas Grégoire 2, 3 Michel Laurentie 1
1 ANSES - Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail
2 PHAR - Pharmacologie des anti-infectieux
3 Université de Poitiers
4 CHU Poitiers - Centre hospitalier universitaire de Poitiers
Abstract : In this study, we assessed the selective effect of colistin orally administered to healthy weaned piglets harbouring an intestinal mcr-1-positive Escherichia coli strain. Maximum recommended dose and a higher dose often used in European pig farms were given by gavage. No selection of the mcr-1-positive strain was observed in our controlled conditions whatever the dose. Further investigations in real farming conditions seem necessary.
Keywords : MCR-1 oral administration colistin piglet veterinary drug efficacity
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https://hal-anses.archives-ouvertes.fr/anses-01570163
Contributor : Emmanuelle Chiffoleau <>
Submitted on : Friday, July 28, 2017 - 3:32:17 PM
Last modification on : Wednesday, January 8, 2020 - 1:20:08 PM

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ANSES | UNIV-POITIERS | PHAR

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Alexis Viel, Jérôme Henri, Agnès Perrin-Guyomard, Julian Laroche, William Couet, et al.. Lack of experimental evidence to support mcr-1- positive escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets. International Journal of Antimicrobial Agents, Elsevier, 2017, pp.1-15. ⟨10.1016/j.ijantimicag.2017.04.013⟩. ⟨anses-01570163⟩

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