Lack of experimental evidence to support mcr-1- positive escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets

Alexis Viel; Jérôme Henri; Agnès Perrin-Guyomard; Julian Laroche; William Couet; Nicolas Grégoire; Michel Laurentie

doi:10.1016/j.ijantimicag.2017.04.013

Journal articles

Lack of experimental evidence to support mcr-1- positive escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets

Alexis Viel ^{1, 2, 3} Jérôme Henri ¹ Agnès Perrin-Guyomard ¹ Julian Laroche ^{2, 4} William Couet ^{2, 4, 3} Nicolas Grégoire ^{2, 3} Michel Laurentie ¹

1 ANSES - Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail

2 PHAR - Pharmacologie des anti-infectieux

3 Université de Poitiers

4 CHU Poitiers - Centre hospitalier universitaire de Poitiers

Abstract : In this study, we assessed the selective effect of colistin orally administered to healthy weaned piglets harbouring an intestinal mcr-1-positive Escherichia coli strain. Maximum recommended dose and a higher dose often used in European pig farms were given by gavage. No selection of the mcr-1-positive strain was observed in our controlled conditions whatever the dose. Further investigations in real farming conditions seem necessary.

Keywords : oral administration colistin piglet veterinary drug efficacity MCR-1

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Pharmaceutical sciences / Medication

Life Sciences [q-bio] / Animal biology / Veterinary medicine and animal Health

Complete list of metadatas

Cited literature [21 references] Display Hide Download

https://hal-anses.archives-ouvertes.fr/anses-01570163
Contributor : Emmanuelle Chiffoleau <>
Submitted on : Monday, June 22, 2020 - 4:42:17 PM
Last modification on : Friday, June 26, 2020 - 3:54:50 PM

vielpreprint128.pdf

Files produced by the author(s)

Lack of experimental evidence to support mcr-1- positive escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets

File

Identifiers

Collections

Citation

Export

Metrics

208

60

Lack of experimental evidence to support mcr-1- positive escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets

File

Identifiers

Collections

Citation

Export

Share

Metrics

208

60