Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, EpiSciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Lack of experimental evidence to support mcr-1- positive escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets

Alexis Viel 1, 2, 3 Jérôme Henri 1 Agnès Perrin-Guyomard 1 Julian Laroche 2, 4 William Couet 2, 4, 3 Nicolas Grégoire 2, 3 Michel Laurentie 1 
1 ANSES - Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail
2 PHAR - Pharmacologie des anti-infectieux
3 Université de Poitiers
4 CHU Poitiers - Centre hospitalier universitaire de Poitiers
Abstract : In this study, we assessed the selective effect of colistin orally administered to healthy weaned piglets harbouring an intestinal mcr-1-positive Escherichia coli strain. Maximum recommended dose and a higher dose often used in European pig farms were given by gavage. No selection of the mcr-1-positive strain was observed in our controlled conditions whatever the dose. Further investigations in real farming conditions seem necessary.
Keywords : MCR-1 oral administration colistin piglet veterinary drug efficacity
Document type :
Journal articles
Complete list of metadata

Cited literature [21 references]  Display  Hide  Download
https://hal-anses.archives-ouvertes.fr/anses-01570163
Contributor : Emmanuelle Chiffoleau Connect in order to contact the contributor
Submitted on : Monday, June 22, 2020 - 4:42:17 PM
Last modification on : Wednesday, April 13, 2022 - 1:28:02 PM

File

Vignette du document
vielpreprint128.pdf
Files produced by the author(s)

Identifiers

Collections

INSERM | ANSES | UNIV-POITIERS | PHAR

Citation

Alexis Viel, Jérôme Henri, Agnès Perrin-Guyomard, Julian Laroche, William Couet, et al.. Lack of experimental evidence to support mcr-1- positive escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets. International Journal of Antimicrobial Agents, Elsevier, 2017, 51 (1), pp.128-131. ⟨10.1016/j.ijantimicag.2017.04.013⟩. ⟨anses-01570163⟩

Export

BibTeX TEI DC DCterms EndNote Datacite

Share

Metrics

Record views

141

Files downloads

121