Lack of experimental evidence to support mcr-1- positive escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets

Alexis Viel; Jérôme Henri; Agnès Perrin-Guyomard; Julian Laroche; William Couet; Nicolas Grégoire; Michel Laurentie

doi:10.1016/j.ijantimicag.2017.04.013

Lack of experimental evidence to support mcr-1- positive escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets

Alexis Viel ^{1, 2, 3} Jérôme Henri ¹ Agnès Perrin-Guyomard ¹ Julian Laroche ^{2, 4} William Couet ^{2, 4, 3} Nicolas Grégoire ^{2, 3} Michel Laurentie ¹

1 Anses Laboratoire de Fougères

2 Pharmacologie des anti-infectieux

3 Université de Poitiers

4 CHU Poitiers - Centre hospitalier universitaire de Poitiers

Abstract : In this study, we assessed the selective effect of colistin orally administered to healthy weaned piglets harbouring an intestinal mcr-1-positive Escherichia coli strain. Maximum recommended dose and a higher dose often used in European pig farms were given by gavage. No selection of the mcr-1-positive strain was observed in our controlled conditions whatever the dose. Further investigations in real farming conditions seem necessary.

Mots-clés : médicament vétérinaire colistine cochon efficacité administration orale Escherichia coli

Type de document :

Article dans une revue

International Journal of Antimicrobial Agents, Elsevier, 2017, pp.1-15. 〈http://www.sciencedirect.com/science/article/pii/S0924857917302121?via%3Dihub〉. 〈10.1016/j.ijantimicag.2017.04.013〉

Domaine :

Sciences du Vivant [q-bio] / Biologie animale / Médecine vétérinaire et santé animal

Liste complète des métadonnées

https://hal-anses.archives-ouvertes.fr/anses-01570163
Contributeur : Emmanuelle Chiffoleau <>
Soumis le : vendredi 28 juillet 2017 - 15:32:17
Dernière modification le : vendredi 3 août 2018 - 16:10:03

Alexis Viel, Jérôme Henri, Agnès Perrin-Guyomard, Julian Laroche, William Couet, et al.. Lack of experimental evidence to support mcr-1- positive escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets. International Journal of Antimicrobial Agents, Elsevier, 2017, pp.1-15. 〈http://www.sciencedirect.com/science/article/pii/S0924857917302121?via%3Dihub〉. 〈10.1016/j.ijantimicag.2017.04.013〉. 〈anses-01570163〉

Lack of experimental evidence to support mcr-1- positive escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets

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Lack of experimental evidence to support mcr-1- positive escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets

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