Lack of experimental evidence to support mcr-1- positive escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets

Alexis Viel (1, 2, 3) , Jérôme Henri (1) , Agnès Perrin-Guyomard (1) , Julian Laroche (2, 4) , William Couet (2, 4, 3) , Nicolas Grégoire (2, 3) , Michel Laurentie (1)

1 ANSES - Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail
2 PHAR - Pharmacologie des anti-infectieux
3 Université de Poitiers
4 CHU Poitiers - Centre hospitalier universitaire de Poitiers

In this study, we assessed the selective effect of colistin orally administered to healthy weaned piglets harbouring an intestinal mcr-1-positive Escherichia coli strain. Maximum recommended dose and a higher dose often used in European pig farms were given by gavage. No selection of the mcr-1-positive strain was observed in our controlled conditions whatever the dose. Further investigations in real farming conditions seem necessary.

Keywords: MCR-1; oral administration; colistin; piglet; veterinary drug; efficacity

Keywords: médicament vétérinaire; colistine; cochon; efficacité; administration orale; Escherichia coli

Domains: Life Sciences [q-bio]; Pharmaceutical sciences; Medication; Life Sciences [q-bio]; Animal biology; Veterinary medicine and animal Health

Alexis Viel, Jérôme Henri, Agnès Perrin-Guyomard, Julian Laroche, William Couet, et al.. Lack of experimental evidence to support mcr-1- positive escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets. International Journal of Antimicrobial Agents, 2017, 51 (1), pp.128-131. ⟨10.1016/j.ijantimicag.2017.04.013⟩. ⟨anses-01570163⟩