An updated review of the epidemiological evidence that cigarette smoking increases risk of colorectal cancer, Cancer. Epidemiol. Biomarkers. Prev, vol.10, issue.1, pp.725-731, 2001. ,
The less harmful cigarette, Preventive Medicine, vol.9, issue.2, pp.767-790, 1991. ,
DOI : 10.1016/0091-7435(80)90089-4
Detection of a carcinogen, 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine, in airborne particles and diesel-exhaust particles, Environmental Pollution, vol.80, issue.3, pp.281-286, 1993. ,
DOI : 10.1016/0269-7491(93)90049-T
Quantitative Analysis of Six Heterocyclic Aromatic Amines in Mainstream Cigarette Smoke Condensate Using Isotope Dilution Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry, Nicotine & Tobacco Research, vol.13, issue.2, pp.120-126, 2011. ,
DOI : 10.1093/ntr/ntq219
Letters to the editor, tobacco smoke components. Beiträge zur Tabakforschung International/Contributions to Tobacco Research, 1998. ,
DOI : 10.2478/cttr-2013-0668
URL : https://doi.org/10.2478/cttr-2013-0668
Analysis of ??- and ??-carbolines in mainstream smoke of reference cigarettes by gas chromatography???mass spectrometry, Journal of Chromatography A, vol.1046, issue.1-2, pp.211-216, 2004. ,
DOI : 10.1016/S0021-9673(04)01030-1
Amino-??-carbolines as mutagenic agents in cigarette smoke condensate, Cancer Letters, vol.10, issue.2, pp.141-149, 1980. ,
DOI : 10.1016/0304-3835(80)90037-3
Chemical Studies on Tobacco Smoke LXIV. On the Analysis of Aromatic Amines in Cigarette Smoke*, Journal of Analytical Toxicology, vol.3, issue.4, pp.150-154, 1979. ,
DOI : 10.1093/jat/3.4.150
Analysis of Polycyclic Aromatic Hydrocarbons in the Particulate Phase of Cigarette Smoke Using a Gas Chromatographic-High-Resolution Mass Spectrometric Technique, Journal of Chromatographic Science, vol.40, issue.7, pp.403-408, 2002. ,
DOI : 10.1093/chromsci/40.7.403
Human urinary carcinogen metabolites: biomarkers for investigating tobacco and cancer, Carcinogenesis, vol.23, issue.6, pp.907-922, 2002. ,
DOI : 10.1093/carcin/23.6.907
URL : https://academic.oup.com/carcin/article-pdf/23/6/907/19254838/230907.pdf
Tobacco smoking and urinary levels of 2-amino-9H-pyrido, Cancer. Epidemiol. Biomarkers. Prev, vol.2, issue.16, pp.1554-1560, 2007. ,
DOI : 10.1158/1055-9965.epi-07-0132
URL : http://cebp.aacrjournals.org/content/cebp/16/8/1554.full.pdf
Simultaneous determination of fifteen heterocyclic aromatic amines in the urine of smokers and nonsmokers using ultra-high performance liquid chromatography???tandem mass spectrometry, Journal of Chromatography A, vol.1333, issue.16, pp.45-53, 2014. ,
DOI : 10.1016/j.chroma.2014.01.057
3-b]indole and 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Urine: Effects of Cigarette Smoking, Chem. Res. Toxicol, vol.2, issue.28, pp.2390-2399 ,
Carcinogenicity in mice of mutagenic compounds from glutamic acid and soybean globulin pyrolysates, Carcinogenesis, vol.5, issue.6, pp.815-819, 1984. ,
DOI : 10.1093/carcin/5.6.815
]pyridine and amino(??)carboline, Carcinogenesis, vol.17, issue.10, pp.2259-2265, 1996. ,
DOI : 10.1093/carcin/17.10.2259
Agreement of mutational characteristics of heterocyclic amines in lacI of the Big Blue mouse with those in tumor related genes in rodents, Carcinogenesis, vol.18, issue.4, pp.745-748, 1997. ,
DOI : 10.1093/carcin/18.4.745
Heterocyclic aromatic amines induce DNA strand breaks and cell transformation, Carcinogenesis, vol.20, issue.4, pp.545-551, 1999. ,
DOI : 10.1093/carcin/20.4.545
URL : https://academic.oup.com/carcin/article-pdf/20/4/545/19259379/545.pdf
Investigation of the genotoxic effects of 2-amino-9H-pyrido[2,3-b]indole in different organs of rodents and in human derived cells, Journal of Chromatography B, vol.802, issue.1, pp.167-173, 2004. ,
DOI : 10.1016/j.jchromb.2003.10.042
]indole and 4-Aminobiphenyl Are Formed at Environmental Exposure Levels and Persist in Human Hepatocytes, Chemical Research in Toxicology, vol.26, issue.9, pp.1367-1377, 2013. ,
DOI : 10.1021/tx4002226
URL : https://hal.archives-ouvertes.fr/inserm-00869907
DNA Adduct Formation of 4-Aminobiphenyl and Heterocyclic Aromatic Amines in Human Hepatocytes, Chemical Research in Toxicology, vol.24, issue.6, pp.913-925, 2011. ,
DOI : 10.1021/tx200091y
URL : https://hal.archives-ouvertes.fr/hal-00609223
Identification of the major hepatic DNA adduct formed by the food mutagen 2-amino-9H-pyrido, Chem. Res. Toxicol, vol.2, issue.10, pp.1192-1197, 1997. ,
Excretion of metabolites in urine and faeces from rats dosed with the heterocyclic amine, 2-amino-9H-pyrido[2,3-b]indole (A??C), Food and Chemical Toxicology, vol.42, issue.6, pp.879-885, 2004. ,
DOI : 10.1016/j.fct.2004.01.011
]indole, Chemical Research in Toxicology, vol.22, issue.4, pp.726-733, 2009. ,
DOI : 10.1021/tx800473w
URL : https://hal.archives-ouvertes.fr/hal-01485263
Metabolic activation of 2-amino-9H-pyrido[2,3-b]indole by rat-liver microsomes, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.95, issue.2-3, pp.159-170, 1982. ,
DOI : 10.1016/0027-5107(82)90254-8
Metabolism of 2-amino-alpha-carboline. A food-borne heterocyclic amine mutagen and carcinogen by human and rodent liver microsomes and by human cytochrome P4501A2, Drug. Metab. Dispos, vol.24, pp.395-400, 1996. ,
In vitro bioactivation of N-hydroxy-2- amino-alpha-carboline, Carcinogenesis, vol.21, pp.1347-1354, 2000. ,
Metabolism and Biomarkers of Heterocyclic Aromatic Amines in Molecular Epidemiology Studies: Lessons Learned from Aromatic Amines, Chemical Research in Toxicology, vol.24, issue.8, pp.1169-1214, 2011. ,
DOI : 10.1021/tx200135s
Glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine by human microsomal UDP-glucuronosyltransferases: identification of specific UGT1A family isoforms involved, Carcinogenesis, vol.20, issue.6, pp.1107-1114, 1999. ,
DOI : 10.1093/carcin/20.6.1107
-Hydroxy-PhIP in Vitro, Chemical Research in Toxicology, vol.17, issue.8, pp.1137-1144, 2004. ,
DOI : 10.1021/tx049898m
]indole, Journal of Biological Chemistry, vol.1, issue.507, pp.14960-14972, 2012. ,
DOI : 10.1016/0006-2952(77)90301-X
URL : https://hal.archives-ouvertes.fr/hal-00696860
Meta-analysis of epidemiologic studies on cigarette smoking and liver cancer, International Journal of Epidemiology, vol.38, issue.6, pp.1497-1511, 2009. ,
DOI : 10.1093/ije/dyp280
Tobacco and Cancer: Recent Epidemiological Evidence, JNCI Journal of the National Cancer Institute, vol.96, issue.2, pp.99-106, 2004. ,
DOI : 10.1093/jnci/djh014
URL : https://academic.oup.com/jnci/article-pdf/96/2/99/10892521/zv800204000099.pdf
Two food-borne heterocyclic amines: Metabolism and DNA adduct formation of amino-??-carbolines, Molecular Nutrition & Food Research, vol.40, issue.3, pp.263-273, 2005. ,
DOI : 10.1016/0027-5107(85)90098-3
URL : http://orbit.dtu.dk/en/publications/two-foodborne-heterocyclic-amines-metabolism-and-dna-adduct-formation-of-aminoalphacarbolines(affb2d79-8694-473f-9513-d578ba757953).html
In vitro Metabolism of Two Heterocyclic Amines, 2-Amino-9H-pyrido[2,3-b]indole (AalphaC) and 2-Amino-3-methyl-9H-pyrido[2,3-b]indole (MeAalphaC) in Human and Rat Hepatic Microsomes, Pharmacology and Toxicology, vol.10, issue.3, pp.127-134, 2002. ,
DOI : 10.1016/0027-5107(85)90098-3
Detoxification of carcinogenic aromatic and heterocyclic amines by enzymatic reduction of the N-hydroxy derivative, Cancer Letters, vol.143, issue.2, pp.167-171, 1999. ,
DOI : 10.1016/S0304-3835(99)00119-6
Metabolites of the Carcinogen 2-Amino-??-carboline Formed in Male Sprague???Dawley Rats in Vivo and in Rat Hepatocyte and Human HepG2 Cell Incubates, Chemical Research in Toxicology, vol.20, issue.3, pp.497-503, 2007. ,
DOI : 10.1021/tx600303d
]indole Metabolism and DNA Adduct Formation in Liver and Extrahepatic Tissues of Mice, Chemical Research in Toxicology, vol.28, issue.12, pp.2400-2410, 2015. ,
DOI : 10.1021/acs.chemrestox.5b00405
Use of hepatocyte cultures for the study of hepatotoxic compounds, Journal of Hepatology, vol.26, issue.2, pp.73-80, 1997. ,
DOI : 10.1016/S0168-8278(97)80499-0
Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline, Chemical Research in Toxicology, vol.6, issue.5, pp.649-656, 1993. ,
DOI : 10.1021/tx00035a009
Differential effects of phenobarbitone and 3- methylcholanthrene induction on the hepatic microsomal metabolism and cytochrome P-450- binding of phenoxazone and a homologous series of its n-alkyl ethers (alkoxyresorufins), 1983. ,
Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae, Drug. Metab. Dispos, vol.21, pp.43-49, 1993. ,
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Analytical Biochemistry, vol.72, issue.1-2, pp.248-254, 1976. ,
DOI : 10.1016/0003-2697(76)90527-3
32P-postlabelling analysis of bulky aromatic adducts, IARC. Sci. Publ, pp.11-23, 1993. ,
]pyridine by 2-D Linear Quadrupole Ion Trap Mass Spectrometry, Chemical Research in Toxicology, vol.20, issue.2, pp.263-276, 2007. ,
DOI : 10.1021/tx0601713
Inactivation of ATM/ATR DNA damage checkpoint promotes androgen induced chromosomal instability in prostate epithelial cells Structure elucidation of phase II metabolites by tandem mass spectrometry: an overview, PLoS. One. J. Chromatogr. A, vol.7, issue.1067, pp.55-72, 2005. ,
Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines., Proc. Natl. Acad. Sci, pp.7696-7700, 1989. ,
DOI : 10.1073/pnas.86.20.7696
]quinoxaline-8-carboxylic Acid Is a Major Detoxication Pathway Catalyzed by Cytochrome P450 1A2, Chemical Research in Toxicology, vol.14, issue.2, pp.211-221, 2001. ,
DOI : 10.1021/tx000176e
Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rat and human hepatocytes, Carcinogenesis, vol.23, issue.1, pp.115-122, 2002. ,
DOI : 10.1093/carcin/23.1.115
Fifty years of research onN-acetyl-2-aminofluorene, one of the most versatile compounds in experimental cancer research, Journal of Cancer Research and Clinical Oncology, vol.83, issue.7, pp.481-489, 1992. ,
DOI : 10.1007/978-3-642-74775-5_13
Persistent binding of a new reaction product of the carcinogen N-hydroxy-N- 2-acetylaminofluorene with guanine in rat liver DNA in vivo, Cancer. Res, vol.32, pp.2042-2048, 1972. ,
Metabolism of heterocyclic aromatic amines by human hepatocytes and cytochrome P4501A2, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.506, issue.507, pp.506-507, 2002. ,
DOI : 10.1016/S0027-5107(02)00165-3
]pyridine by different cytochrome P450 enzymes, Carcinogenesis, vol.11, issue.3, pp.489-492, 1990. ,
DOI : 10.1093/carcin/11.3.489
EXPRESSION OF CYTOCHROMES P450, CONJUGATING ENZYMES AND NUCLEAR RECEPTORS IN HUMAN HEPATOMA HepaRG CELLS, Drug Metabolism and Disposition, vol.34, issue.1, pp.75-83, 2006. ,
DOI : 10.1124/dmd.105.006759
URL : https://hal.archives-ouvertes.fr/hal-00702085
Bioactivation of Heterocyclic Aromatic Amines by UDP Glucuronosyltransferases, Chemical Research in Toxicology, vol.29, issue.5, pp.879-891, 2016. ,
DOI : 10.1021/acs.chemrestox.6b00046
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868641/pdf
-Amino-9H- pyrido[2,3-b]indole (AalphaC) Adducts and Thiol Oxidation of Serum Albumin as Potential Biomarkers of Tobacco Smoke, J. Biol. Chem, vol.2, issue.290, pp.16304-16318, 2015. ,