S. Pouria, A. De-andrade, J. Barbosa, R. Cavalcanti, V. Barreto et al., Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil, The Lancet, vol.352, issue.9121, pp.352-373, 1998.
DOI : 10.1016/S0140-6736(97)12285-1

P. Rao, N. Gupta, R. Jayaraj, A. Bhaskar, and P. Jatav, Age-dependent effects on biochemical variables and toxicity induced by cyclic peptide toxin microcystin-LR in mice, Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, vol.140, issue.1, pp.11-19, 2005.
DOI : 10.1016/j.cca.2004.11.008

N. Robinson, G. Miura, C. Matson, R. Dinterman, and J. Pace, Characterization of chemically tritiated microcystin-LR and its distribution in mice, Toxicon, vol.27, issue.9, pp.1035-1077, 1989.
DOI : 10.1016/0041-0101(89)90154-2

N. Robinson, J. Pace, C. Matson, G. Miura, and W. Lawrence, Tissue distribution, excretion and hepatic biotransformation of microcystin-LR in mice, Journal of Pharmacology and Experimental Therapeutics, vol.256, pp.176-82, 1991.

A. Sieroslawska, Assessment of the mutagenic potential of cyanobacterial extracts and pure cyanotoxins, Toxicon, vol.74, pp.76-82
DOI : 10.1016/j.toxicon.2013.07.029

A. Sieroslawska and A. Rymuszka, Evaluation of genotoxic potential of neurotoxin anatoxin-a with the use of umuC test, Neuroendocrinology Letters, vol.31, pp.16-20, 2010.

M. Sekijima, T. Tsutsumi, T. Yoshida, T. Harada, F. Tashiro et al., Enhancement of glutathione S-transferase placental-form positive liver cell foci development by microcystin-LR in aflatoxin B1-initiated rats, Carcinogenesis, vol.20, issue.1, pp.161-165, 1999.
DOI : 10.1093/carcin/20.1.161

I. ?etlíková and C. Wiegand, Hepatic and branchial glutathione S-transferases of two fish species: Substrate specificity and biotransformation of microcystin-LR, Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, vol.149, issue.4, pp.515-523, 2009.
DOI : 10.1016/j.cbpc.2008.11.008

P. Solter, G. Wollenberg, X. Huang, F. Chu, and M. Runnegar, Prolonged Sublethal Exposure to the Protein Phosphatase Inhibitor Microcystin-LR Results in Multiple Dose-Dependent Hepatotoxic Effects, Toxicological Sciences, vol.44, issue.1, pp.87-96, 1998.
DOI : 10.1093/toxsci/44.1.87

R. Stoner, W. Adams, D. Slatkin, and H. Siegelman, The effects of single l-amino acid substitutions on the lethal potencies of the microcystins, Toxicon, vol.27, issue.7, pp.825-828, 1989.
DOI : 10.1016/0041-0101(89)90051-2

R. Stotts, M. Namikoshi, W. Haschek, K. Rinehart, W. Carmichael et al., Structural modifications imparting reduced toxicity in microcystins from Microcystis spp., Toxicon, vol.31, issue.6, pp.31-783, 1993.
DOI : 10.1016/0041-0101(93)90384-U

Z. Svir?ev, S. Krstic, M. Miladinov-mikov, V. Balti?, and M. Vidovi?, Freshwater Cyanobacterial Blooms and Primary Liver Cancer Epidemiological Studies in Serbia, Journal of Environmental Science and Health, Part C, vol.123, issue.4, pp.36-55, 2009.
DOI : 10.1533/9781845698164.1.69

S. Takenaka, Covalent glutathione conjugation to cyanobacterial hepatotoxin microcystin LR by F344 rat cytosolic and microsomal glutathione S-transferases, Environmental Toxicology and Pharmacology, vol.9, issue.4, pp.135-139, 2001.
DOI : 10.1016/S1382-6689(00)00049-1

Y. Ueno, Y. Makita, S. Nagata, T. Tsutsumi, F. Yoshida et al., No chronic oral toxicity of a low dose of microcystin-LR, a cyanobacterial hepatotoxin, in female BALB/c mice, Environmental Toxicology, vol.10, issue.2, pp.45-55, 1999.
DOI : 10.1002/(SICI)1522-7278(199902)14:1<45::AID-TOX8>3.0.CO;2-T

P. Vesterkvist, J. Misiorek, L. Spoof, D. Toivola, and J. Meriluoto, Comparative cellular toxicity of hydrophilic and hydrophobic microcystins on Caco-2 cells. Toxins, 4, 1008?1023 induced reactive oxygen species and DNA damage, Toxicon, issue.3, pp.52-518, 2012.

Y. Zhao, Q. Xue, X. Su, L. Xie, Y. Yan et al., Microcystin-LR induced thyroid dysfunction and metabolic disorders in mice, Toxicology, vol.328, pp.135-141, 2015.
DOI : 10.1016/j.tox.2014.12.007

L. Zhou, H. Yu, and K. Chen, Relationship between microcystin in drinking water and colorectal cancer, Biomedical and Environmental Sciences, vol.15, issue.2, pp.166-171, 2002.

W. Zhou, X. Zhang, P. Xie, H. Liang, and X. Zhang, The suppression of hematopoiesis function in Balb/c mice induced by prolonged exposure of microcystin-LR, Toxicology Letters, vol.219, issue.2, pp.194-201, 2013.
DOI : 10.1016/j.toxlet.2013.02.011

N. Bouaïcha, N. Maatouk, I. Plessis, M. Périn, and F. , Genotoxic potential of Microcystin-LR and nodularinin vitro in primary cultured rat hepatocytes andin vivo in rat liver, Environmental Toxicology, vol.557, issue.3, pp.341-348, 2005.
DOI : 10.1002/tox.20110

A. Lankoff, A. Wojcik, V. Fessard, and J. Meriluoto, Nodularin-induced genotoxicity following oxidative DNA damage and aneuploidy in HepG2 cells, Toxicology Letters, vol.164, issue.3, pp.239-248, 2006.
DOI : 10.1016/j.toxlet.2006.01.003

M. Lian, Y. Liu, S. Yu, G. Qian, S. Wan et al., -induced hepatotumorigenesis in mice, World Journal of Gastroenterology, vol.12, issue.19, pp.3065-3072, 2006.
DOI : 10.3748/wjg.v12.i19.3065

URL : https://hal.archives-ouvertes.fr/hal-00959234

T. Ohta, E. Sueoka, N. Iida, A. Komori, M. Suganuma et al., Nodularin, a potent inhibitor of protein phosphatases 1 and 2A, is a new environmental carcinogen in male F344 rat liver, Cancer Research, issue.24, pp.54-6402, 1994.

T. Park, K. Song, S. Sohn, and I. Lim, Marked inhibition of testosterone biosynthesis by the hepatotoxin nodularin due to apoptosis of Leydig cells, Molecular Carcinogenesis, vol.18, issue.3, pp.151-163, 2002.
DOI : 10.1002/mc.10059

K. Sivonen and G. Jones, Cyanobacterial toxins in toxic cyanobacteria in water: a guide to their public health consequences, monitoring and management, I. Chorus and, pp.41-111, 1999.

K. Song, I. Lim, S. Park, S. Lee, H. Park et al., Effect of nodularin on the expression of glutathione S-transferase placental form and proliferating cell nuclear antigen in Nnitrosodiethylamine initiated hepatocarcinogenesis in the male Fischer 344 rat, Carcinogenesis, issue.8, pp.20-1541, 1999.

S. Yoshizawa, R. Matsushima, M. Watanabe, K. Harada, A. Ichihara et al., Inhibition of protein phosphatases by microcystis and nodularin associated with hepatotoxicity, Journal of Cancer Research and Clinical Oncology, vol.26, issue.6, pp.609-614, 1990.
DOI : 10.1007/BF01637082

O. Adeyemo and A. Sirén, Cardio-respiratory changes and mortality in the conscious rat induced by (+)- and (??)-anatoxin-a, Toxicon, vol.30, issue.8, pp.30-899, 1992.
DOI : 10.1016/0041-0101(92)90388-L

R. Aronstam and B. Witkop, Anatoxin-a interactions with cholinergic synaptic molecules., Proceedings of the National Academy of Sciences, pp.4639-4682, 1981.
DOI : 10.1073/pnas.78.7.4639

N. Astrachan, B. Archer, and D. Hilbelink, Evaluation of the subacute toxicity and teratogenicity of anatoxin-a, Toxicon, vol.18, issue.5-6, pp.684-88, 1980.
DOI : 10.1016/0041-0101(80)90100-2

H. Campbell, O. Edwards, J. Elder, and R. Kolt, Total synthesis of DL-anatoxin-a and DLisoanatoxin-a, Polish Journal of Chemistry, vol.53, pp.27-37, 1979.

F. Campos, R. Durán, L. Vidal, L. Faro, and A. M. , In vivo Effects of the Anatoxin-a on Striatal Dopamine Release, Neurochemical Research, vol.90, issue.4, pp.491-501, 2006.
DOI : 10.1007/s11064-006-9042-x

W. Carmichael, N. Mahmood, and E. Hyde, Natural toxins from cyanobacteria (bue-green algae), 1990.

W. Carmichael and I. Falconer, Diseases related to freshwater algal blooms, Algal Toxins in Seafood and Drinking Water, pp.187-209, 1993.

W. Cook, V. Beasley, A. Dahlem, J. Dellinger, K. Harlin et al., Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmineon mouse brain cholinesterase activity, Toxicon, issue.8, pp.26-750, 1988.

W. Cook, J. Dellinger, S. Singh, A. Dahlem, W. Carmichael et al., Regional brain cholinesterase activity in rats injected intraperitoneally with anatoxin-a(s) or paraoxon, Toxicology Letters, vol.49, issue.1, pp.29-34, 1989.
DOI : 10.1016/0378-4274(89)90097-0

J. Devlin, O. Edwards, P. Gorham, N. Hunter, R. Pike et al., NRC-44h, Canadian Journal of Chemistry, vol.55, issue.8, pp.1367-71, 1977.
DOI : 10.1139/v77-189

J. Fawell, R. Mitchell, R. Hill, and . Everett, The toxicity of cyanobacterial toxins in the mouse: II Anatoxin-a, Human & Experimental Toxicology, vol.29, issue.3, pp.168-73
DOI : 10.1177/096032719901800306

R. Fitzgeorge, S. Clark, and C. Keevil, Routes of intoxication Detection Methods for Cyanobacterial Toxins, pp.69-74, 1994.

G. Lilleheil, R. Andersen, O. Skulberg, and A. J. , Effects of a homoanatoxin-a-containing extract from oscillatoria formosa (cyanophyceae/cyanobacteria) on neuromuscular transmission, Toxicon, vol.35, issue.8, pp.1275-89, 1997.
DOI : 10.1016/S0041-0101(97)00013-5

W. Mahmood and W. Carmichael, Anatoxin-a(s), an anticholinesterase from the cyanobacterium Anabaena flos-aquae NRC-525-17, Toxicon, vol.25, issue.11, pp.1211-1238, 1987.
DOI : 10.1016/0041-0101(87)90140-1

S. Matsunaga, R. Moore, W. Niemczura, and W. Carmichael, Anatoxin-a(s), a potent anticholinesterase from Anabaena flos-aquae, Journal of the American Chemical Society, vol.111, issue.20, pp.8021-8024, 1989.
DOI : 10.1021/ja00202a057

M. Namikoshi, T. Murakami, M. Watanabe, T. Oda, J. Yamada et al., Simultaneous production of homoanatoxin-a, anatoxin-a, and a new non-toxic 4-hydroxyhomoanatoxin-a by the cyanobacterium Raphidiopsis mediterranea Skuja, Toxicon, vol.42, issue.5, pp.533-541, 2003.
DOI : 10.1016/S0041-0101(03)00233-2

P. Rao, R. Bhattacharya, N. Gupta, M. Parida, A. Bhaskar et al., Involvement of caspase and reactive oxygen species in cyanobacterial toxin anatoxin-a-induced cytotoxicity and apoptosis in rat thymocytes and Vero cells, Archives of Toxicology, vol.76, pp.227-262, 2002.

W. Repavich, W. Sonzogni, J. Standridge, R. Wedepohl, and L. Meisner, Cyanobacteria (blue-green algae) in wisconsin waters: acute and chronic toxicity, Water Research, vol.24, issue.2, pp.225-231, 1990.
DOI : 10.1016/0043-1354(90)90107-H

E. Rogers, E. Hunter, V. Moser, P. Phillips, J. Herkovitz et al., Potential developmental toxicity of anatoxin-a, a cyanobacterial toxin, Journal of Applied Toxicology, vol.29, issue.6, pp.527-561, 2005.
DOI : 10.1002/jat.1091

A. Sieroslawska, Assessment of the mutagenic potential of cyanobacterial extracts and pure cyanotoxins, Toxicon, vol.74, pp.76-82, 2013.
DOI : 10.1016/j.toxicon.2013.07.029

A. Sieroslawska and A. Rymuszka, Evaluation of genotoxic potential of neurotoxin anatoxin-a with the use of umuC test, Neuroendocrinology Letters, vol.31, pp.16-20, 2010.

O. Skulberg, W. Charmichael, R. Anderson, S. Matsunga, R. Moore et al., Investigations of a neurotoxic oscillatorialean strain (Cyanophyceae) and its toxin. Isolation and characterization of homoanatoxin-a, Environmental Toxicology and Chemistry, vol.67, issue.3, pp.321-330, 1992.
DOI : 10.1002/etc.5620110306

D. Stevens and R. Krieger, Effect of route of exposure and repeated doses on the acute toxicity in mice of the cyanobacterial nicotinic alkaloid anatoxin-a, Toxicon, vol.29, issue.1, pp.134-142, 1991.
DOI : 10.1016/0041-0101(91)90047-U

W. Valentine, D. Schaeffer, and V. Beasley, Electromyographic assessment of the neuromuscular blockade produced in vivo by anatoxin-a in the rat, Toxicon, vol.29, issue.3, pp.347-57, 1991.
DOI : 10.1016/0041-0101(91)90288-3

S. Wonnacott, K. Swanson, E. Albuquerque, N. Huby, P. Thompson et al., Homoanatoxin: A potent analogue of anatoxin-a, Biochemical Pharmacology, vol.43, issue.3, pp.419-442, 1992.
DOI : 10.1016/0006-2952(92)90558-Z

A. Yavasoglu, M. Karaaslan, Y. Uyanikgil, F. Sayim, U. Ates et al., Toxic effects of anatoxin-a on testes and sperm counts of male mice, Experimental and Toxicologic Pathology, vol.60, issue.4-5, pp.391-397, 2008.
DOI : 10.1016/j.etp.2008.04.001

E. Bazin, A. Mourot, A. Humpage, and V. Fessard, Genotoxicity of a freshwater cyanotoxin, cylindrospermopsin, in two human cell lines: Caco-2 and HepaRG, Environmental and Molecular Mutagenesis, vol.32, issue.3, pp.251-259, 2010.
DOI : 10.1002/em.20539

URL : https://hal.archives-ouvertes.fr/hal-00533734

E. Bazin, S. Huet, G. Jarry, L. Hégarat, L. Munday et al., Cytotoxic and genotoxic effects of cylindrospermopsin in mice treated by gavage or intraperitoneal injection, Environmental Toxicology, vol.16, issue.5, pp.277-284, 2010.
DOI : 10.1002/tox.20640

URL : https://hal.archives-ouvertes.fr/hal-00692410

N. Chernoff, E. Rogers, R. Zehr, M. Gage, D. Malarkey et al., Toxicity and recovery in the pregnant mouse after gestational exposure to the cyanobacterial toxin, cylindrospermopsin, Journal of Applied Toxicology, vol.274, issue.3, pp.242-254, 2011.
DOI : 10.1002/jat.1586

N. Chernoff, E. Rogers, R. Zehr, M. Gage, G. Travlos et al., The Course of Toxicity in the Pregnant Mouse After Exposure to the Cyanobacterial Toxin Cylindrospermopsin: Clinical Effects, Serum Chemistries, Hematology, and Histopathology, Journal of Toxicology and Environmental Health, Part A, vol.22, issue.17, pp.77-1040, 2014.
DOI : 10.1080/10937400590889412

M. Chong, B. Wong, P. Lam, G. Shaw, and A. Seawright, Toxicity and uptake mechanism of cylindrospermopsin and lophyrotomin in primary rat hepatocytes, Toxicon, vol.40, issue.2, pp.205-211, 2002.
DOI : 10.1016/S0041-0101(01)00228-8

C. De-almeida, C. De-arruda, A. , C. De-queiroz, E. et al., Oral exposure to cylindrospermopsin in pregnant rats: Reproduction and foetal toxicity studies, Toxicon, vol.74, pp.127-129, 2013.
DOI : 10.1016/j.toxicon.2013.08.051

I. Falconer, S. Hardy, A. Humpage, S. Froscio, G. Tozer et al., Hepatic and renal toxicity of the blue-green alga (cyanobacterium)Cylindrospermopsis raciborskii in male Swiss albino mice, Environmental Toxicology, vol.32, issue.1, pp.143-150, 1999.
DOI : 10.1002/(SICI)1522-7278(199902)14:1<143::AID-TOX18>3.0.CO;2-H

V. Fessard and C. Bernard, Cell alterations but no DNA strand breaks inducedin vitro by cylindrospermopsin in CHO K1 cells, Environmental Toxicology, vol.122, issue.5, pp.353-359, 2003.
DOI : 10.1002/tox.10136

S. Froscio, A. Humpage, P. Burcham, and I. Falconer, Cell-free protein synthesis inhibition assay for the cyanobacterial toxin cylindrospermopsin, Environmental Toxicology, vol.654, issue.5, pp.408-412, 2001.
DOI : 10.1002/tox.1050

S. Froscio, A. Humpage, P. Burcham, and I. Falconer, Cylindrospermopsin-induced protein synthesis inhibition and its dissociation from acute toxicity in mouse hepatocytes, Environmental Toxicology, vol.32, issue.4, pp.243-251, 2003.
DOI : 10.1002/tox.10121

A. Humpage and I. Falconer, Oral toxicity of the cyanobacterial toxin cylindrospermopsin in male Swiss albino mice: Determination of no observed adverse effect level for deriving a drinking water guideline value, Environmental Toxicology, vol.122, issue.2, pp.94-103, 2003.
DOI : 10.1002/tox.10104

A. Humpage, F. Fontaine, S. Froscio, P. Burcham, and I. Falconer, Cylindrospermopsin Genotoxicity and Cytotoxicity: Role Of Cytochrome P-450 and Oxidative Stress, Journal of Toxicology and Environmental Health, Part A, vol.21, issue.9, pp.739-753, 2005.
DOI : 10.1016/0041-0101(94)90008-6

A. Lankoff, A. Wojcik, H. Lisowska, J. Bialczyk, D. Dziga et al., No induction of structural chromosomal aberrations in cylindrospermopsin-treated CHO-K1 cells without and with metabolic activation, Toxicon, vol.50, issue.8, pp.50-1105, 2007.
DOI : 10.1016/j.toxicon.2007.07.021

M. Maire, E. Bazin, V. Fessard, C. Rast, A. Humpage et al., Morphological cell transformation of Syrian hamster embryo (SHE) cells by the cyanotoxin, cylindrospermopsin, Toxicon, vol.55, issue.7, pp.55-1317, 2010.
DOI : 10.1016/j.toxicon.2010.01.025

URL : https://hal.archives-ouvertes.fr/hal-00533772

R. Norris, A. Seawright, G. Shaw, M. Smith, R. Chiswell et al., Distribution of 14C cylindrospermopsin in vivo in the mouse, Environmental Toxicology, vol.16, issue.6, pp.498-505, 2001.
DOI : 10.1002/tox.10008.abs

I. Ohtani, R. Moore, and M. Runnegar, Cylindrospermopsin: a potent hepatotoxin from the blue-green alga Cylindrospermopsis raciborskii, Journal of the American Chemical Society, vol.114, issue.20, pp.7941-7942, 1992.
DOI : 10.1021/ja00046a067

E. Rogers, R. Zehr, M. Gage, A. Humpage, I. Falconer et al., The cyanobacterial toxin, cylindrospermopsin, induces fetal toxicity in the mouse after exposure late in gestation, Toxicon, vol.49, issue.6, pp.49-855, 2007.
DOI : 10.1016/j.toxicon.2006.12.009

A. Seawright, C. Nolan, G. Shaw, R. Chiswell, R. Norris et al., The oral toxicity for mice of the tropical cyanobacteriumCylindrospermopsis raciborskii (Woloszynska), Environmental Toxicology, vol.32, issue.1, pp.135-142, 1999.
DOI : 10.1002/(SICI)1522-7278(199902)14:1<135::AID-TOX17>3.0.CO;2-L

G. Shaw, Cylindrospermopsin, A Cyanobacterial Alkaloid: Evaluation of Its Toxicologic Activity, Therapeutic Drug Monitoring, vol.22, issue.1, pp.89-92, 2000.
DOI : 10.1097/00007691-200002000-00019

A. Sieroslawska, Assessment of the mutagenic potential of cyanobacterial extracts and pure cyanotoxins, Toxicon, vol.74, pp.76-82
DOI : 10.1016/j.toxicon.2013.07.029

A. Sukenik, M. Reisner, S. Carmeli, and M. Werman, Oral toxicity of the cyanobacterial toxin cylindrospermopsin in mice: Long-term exposure to low doses, Environmental Toxicology, vol.13, issue.6, pp.575-582, 2006.
DOI : 10.1002/tox.20220

K. Terao, S. Ohmori, K. Igarashi, I. Ohtani, M. Watanabe et al., Electron microscopic studies on experimental poisoning in mice induced by cylindrospermopsin isolated from blue-green alga Umezakia natans, Toxicon, vol.32, issue.7, pp.32-833, 1994.
DOI : 10.1016/0041-0101(94)90008-6

E. Alonso, A. Alfonso, M. Vieytes, and L. Botana, Evaluation of toxicity equivalent factors of paralytic shellfish poisoning toxins in seven human sodium channels types by an automated high throughput electrophysiology system, Archives of Toxicology, vol.8, issue.7, 2015.
DOI : 10.1007/s00204-014-1444-y

C. Da-silva, E. De-morais, M. Costa, J. Ribas, I. Guiloski et al., Saxitoxins induce cytotoxicity, genotoxicity and oxidative stress in teleost neurons in??vitro, Toxicon, vol.86, pp.8-15, 2014.
DOI : 10.1016/j.toxicon.2014.04.016

C. García, A. Barriga, J. Díaz, M. Lagos, and N. Lagos, Route of metabolization and detoxication of paralytic shellfish toxins in humans, Toxicon, vol.55, issue.1, pp.135-179, 2010.
DOI : 10.1016/j.toxicon.2009.07.018

R. Munday, K. Thomas, R. Gibbs, C. Murphy, and M. Quilliam, Acute toxicities of saxitoxin, neosaxitoxin, decarbamoyl saxitoxin and gonyautoxins 1&4 and 2&3 to mice by various routes of administration, Toxicon, vol.76, pp.77-83, 2013.
DOI : 10.1016/j.toxicon.2013.09.013

R. Zepeda, M. Candiracci, N. Lobos, S. Lux, and H. Miranda, Chronic Toxicity Study of Neosaxitoxin in Rats, Marine Drugs, vol.12, issue.9, pp.5055-71, 2014.
DOI : 10.3390/md12095055

P. Ciminiello, C. Dell-'aversano, D. Iacovo, E. Fattorusso, E. Forino et al., Subspecies, Chemical Research in Toxicology, vol.22, issue.11, pp.1851-1859, 2009.
DOI : 10.1021/tx900259v

D. Favero, G. Sosa, S. Poli, M. Tubaro, A. Sbaizero et al., In vivo and in vitro effects of 42-hydroxy-palytoxin on mouse skeletal muscle: Structural and functional impairment, Toxicology Letters, vol.225, issue.2, pp.285-93, 2014.
DOI : 10.1016/j.toxlet.2013.12.020

D. Favero, G. Beltramo, D. Sciancalepore, M. Lorenzon, P. Coslovich et al., Toxicity of palytoxin after repeated oral exposure in mice and in??vitro effects on cardiomyocytes, Toxicon, vol.75, pp.3-15, 2013.
DOI : 10.1016/j.toxicon.2013.06.003

T. Yasumoto, EFSA Panel on Contaminants in the Food Chain (CONTAM) Scientific Opinion on marine biotoxins in shellfish ? Palytoxin group Toxicological studies on palytoxin and ostreocin-D administered to mice by three different routes, EFSA Journal Toxicon, vol.7, issue.123, pp.54-244, 2009.

. Mundayr, Occurrence and toxicology of palytoxin Seafood and Freshwater Toxins. Pharmacology, Physiology and Detection, pp.693-713, 2008.

S. Sosa, D. Favero, G. , D. Bortoli, M. Vita et al., Palytoxin toxicity after acute oral administration in mice, Toxicology Letters, vol.191, issue.2-3, pp.253-259, 2009.
DOI : 10.1016/j.toxlet.2009.09.009

A. Tubaro, D. Favero, G. Beltramo, D. Ardizzone, M. Forino et al., Acute oral toxicity in mice of a new palytoxin analog: 42-Hydroxy-palytoxin, Toxicon, vol.57, issue.5, pp.755-763, 2011.
DOI : 10.1016/j.toxicon.2011.02.009

A. Tubaro, P. Durando, D. Favero, G. Ansaldi, F. Icardi et al., Case definitions for human poisonings postulated to palytoxins exposure, Toxicon, vol.57, issue.3, pp.478-495
DOI : 10.1016/j.toxicon.2011.01.005

B. Dechraoui, M. Rezvani, A. Gordon, C. Levin, E. Ramsdell et al., Repeat exposure to ciguatoxin leads to enhanced and sustained thermoregulatory, pain threshold and motor activity responses in mice: Relationship to blood ciguatoxin concentrations, Toxicology, vol.246, issue.1, pp.55-62, 2008.
DOI : 10.1016/j.tox.2007.12.013

M. Bottein, Z. Wang, and J. Ramsdell, Toxicokinetics of the ciguatoxin P-CTX-1 in rats after intraperitoneal or oral administration, Toxicology, vol.284, issue.1-3, pp.1-3, 2011.
DOI : 10.1016/j.tox.2011.02.005

B. Dechraoui, M. Wang, Z. Turquet, J. Chinain, M. Darius et al., Biomonitoring of ciguatoxin exposure in mice using blood collection cards, Toxicon, vol.46, issue.3, pp.243-251, 2005.
DOI : 10.1016/j.toxicon.2005.03.014

A. Kerbrat, H. Darius, S. Pauillac, M. Chinain, and D. Laurent, Detection of ciguatoxin-like and paralysing toxins in Trichodesmium spp. from New Caledonia lagoon, Marine Pollution Bulletin, vol.61, issue.7-12, pp.61-68, 2010.
DOI : 10.1016/j.marpolbul.2010.06.017

D. Laurent, A. Kerbrat, H. Darius, E. Girard, S. Golubic et al., Are cyanobacteria involved in Ciguatera Fish Poisoning-like outbreaks in New Caledonia? Harmful Algae, pp.827-838, 2008.

L. Jaja-chimedza, A. Gantar, M. Mayer, G. Gibbs, P. Berry et al., Effects of Cyanobacterial Lipopolysaccharides from Microcystis on Glutathione-Based Detoxification Pathways in the Zebrafish (Danio rerio) Embryo, Toxins, vol.4, issue.12, pp.390-404, 2012.
DOI : 10.3390/toxins4060390

A. Katz, J. Weckesser, G. Drews, and H. Mayer, Chemical and biological studies on the lipopolysaccharide (O-antigen) of Anacystis nidulans, Archives of Microbiology, vol.7, issue.3, pp.247-256, 1977.
DOI : 10.1007/BF00492032

G. Keleti and J. Sykora, Production and properties of cyanobacterial endotoxins, Applied and Environmental Microbiology, vol.43, issue.1, pp.104-113, 1982.

A. Mayer, J. Clifford, M. Aldulescu, J. Frenkel, M. Holland et al., Cyanobacterial Microcystis aeruginosa Lipopolysaccharide Elicits Release of Superoxide Anion, Thromboxane B2, Cytokines, Chemokines, and Matrix Metalloproteinase-9 by Rat Microglia, Toxicological Sciences, vol.121, issue.1, pp.63-72, 2011.
DOI : 10.1093/toxsci/kfr045

S. Raziuddin, H. Siegelman, and T. Tornabene, Lipopolysaccharides of the cyanobacterium Microcystis aeruginosa, European Journal of Biochemistry, vol.113, issue.1-2, pp.333-336, 1983.
DOI : 10.1007/BF00364907

I. Stewart, P. Schluter, and G. Shaw, Cyanobacterial lipopolysaccharides and human health ??? a review, Environmental Health, vol.130, issue.1, p.7, 2006.
DOI : 10.1080/09603120050127158

M. Andersson, O. Karlsson, U. Bergström, E. Brittebo, and I. Brandt, Maternal Transfer of the Cyanobacterial Neurotoxin ??-N-Methylamino-L-Alanine (BMAA) via Milk to Suckling Offspring, PLoS ONE, vol.22, issue.422, p.78133, 2013.
DOI : 10.1371/journal.pone.0078133.g006

T. Caller, J. Doolin, J. Haney, A. Murby, K. West et al., A cluster of amyotrophic lateral sclerosis in New Hampshire: A possible role for toxic cyanobacteria blooms, Amyotrophic Lateral Sclerosis, vol.6, issue.3, pp.101-109, 2009.
DOI : 10.3109/17482960903278485

M. Duncan, N. Villacreses, P. Pearson, L. Wyatt, S. Rapoport et al., 2-amino-3-(methylamino)-propanoic acid (BMAA) pharmacokinetics and blood-brain barrier permeability in the rat, Journal of Pharmacology and Experimental Therapies, vol.258, issue.1, pp.27-35, 1991.

M. Duncan, S. Markey, B. Weick, P. Pearson, H. Ziffer et al., 2-Amino-3-(methylamino)propanoic acid (BMAA) bioavailability in the primate, Neurobiology of Aging, vol.13, issue.2, pp.333-340, 1992.
DOI : 10.1016/0197-4580(92)90047-2

M. Engskog, O. Karlsson, J. Haglöf, A. Elmsjö, E. Brittebo et al., The cyanobacterial amino acid ??-N-methylamino-l-alanine perturbs the intermediary metabolism in neonatal rats, Toxicology, vol.312, pp.312-318, 2013.
DOI : 10.1016/j.tox.2013.07.010

O. Karlsson, L. Jiang, M. Andersson, L. Ilag, and E. Brittebo, Protein association of the neurotoxin and non-protein amino acid BMAA (??-N-methylamino-l-alanine) in the liver and brain following neonatal administration in rats, Toxicology Letters, vol.226, issue.1, pp.1-5, 2014.
DOI : 10.1016/j.toxlet.2014.01.027

O. Karlsson, E. Roman, and E. Brittebo, Long-term Cognitive Impairments in Adult Rats Treated Neonatally with ??-N-Methylamino-L-Alanine, Toxicological Sciences, vol.112, issue.1, pp.185-195, 2009.
DOI : 10.1093/toxsci/kfp196

O. Karlsson, A. Berg, A. Lindstrom, G. Arnerup, E. Roman et al., Neonatal Exposure to the Cyanobacterial Toxin BMAA Induces Changes in Protein Expression and Neurodegeneration in Adult Hippocampus, Toxicological Sciences, vol.130, issue.2, pp.391-404, 2012.
DOI : 10.1093/toxsci/kfs241

E. Masseret, S. Banack, F. Boumédiène, E. Abadie, L. Brient et al., Dietary BMAA Exposure in an Amyotrophic Lateral Sclerosis Cluster from Southern France, PLoS ONE, vol.307, issue.12, p.83406
DOI : 10.1371/journal.pone.0083406.t002

URL : https://hal.archives-ouvertes.fr/hal-00933857

Q. Smith, H. Nagura, Y. Takada, and M. Duncan, Facilitated Transport of the Neurotoxin, ?-N-Methylamino-l-Alanine, Across the Blood-Brain Barrier, Journal of Neurochemistry, vol.20, issue.4, pp.1330-1337, 1992.
DOI : 10.1016/0304-4157(85)90015-2

P. Spencer, J. Hugon, A. Ludolph, P. Nunn, S. Ross et al., Discovery and Partial Characterization of Primate Motor-System Toxins, Ciba Foundation Symposium, vol.47, pp.221-259, 1987.
DOI : 10.1002/9780470513422.ch14

X. Xie, M. Basile, and D. Mash, Cerebral uptake and protein incorporation of cyanobacterial toxin ??-N-methylamino-L-alanine, NeuroReport, vol.24, issue.14, pp.779-84, 2013.
DOI : 10.1097/WNR.0b013e328363fd89

H. Fujiki, T. Sugimura, and R. Moore, New classes of environmental tumor promoters: indole alkaloids and polyacetates, Environmental Health Perspectives, vol.50, pp.85-90, 1983.
DOI : 10.1289/ehp.835085

H. Fujiki, M. Mori, M. Nakayasu, M. Terada, T. Sugimura et al., Indole alkaloids: dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters., Proceedings of the National Academy of Sciences U S A, pp.78-3872, 1981.
DOI : 10.1073/pnas.78.6.3872

E. Ito and H. Nagai, Bleeding from the small intestine caused by aplysiatoxin, the causative agent of the red alga Gracilaria coronopifolia poisoning, Toxicon, vol.38, issue.1, pp.123-155, 2000.
DOI : 10.1016/S0041-0101(99)00144-0

E. Ito, M. Satake, and T. Yasumoto, Pathological effects of lyngbyatoxin A upon mice, Toxicon, vol.40, issue.5, pp.551-557, 2002.
DOI : 10.1016/S0041-0101(01)00251-3

J. Mullin, . Mcginn, . Mt, . Snock, . Kv et al., The effects of teleocidin and aplysiatoxin tumor promoters on epithelial tight junctions and transepithelial permeability: comparison to phorbol esters, Carcinogenesis, vol.11, issue.3, pp.377-386, 1990.
DOI : 10.1093/carcin/11.3.377

N. Osborne, P. Webb, and G. Shaw, The toxins of Lyngbya majuscula and their human and ecological health effects, Environment International, vol.27, issue.5, pp.381-92, 2001.
DOI : 10.1016/S0160-4120(01)00098-8

N. Osborne, A. Seawright, and G. Shaw, Dermal toxicology of Lyngbya majuscula, from Moreton Bay, pp.584-589, 2008.

J. Bartram, Y. Chartier, and J. Lee, Legionella and the prevention of legionellosis. World Health Organization, 2007.

E. Briand, C. Yepremian, J. Humbert, and C. Quiblier, (cyanobacteria) strains under different environmental conditions, Environmental Microbiology, vol.151, issue.12, pp.3337-3348, 2008.
DOI : 10.1111/j.1462-2920.2008.01730.x

T. Davis, D. Berry, G. Boyer, and C. Gobler, The effects of temperature and nutrients on the growth and dynamics of toxic and non-toxic strains of Microcystis during cyanobacteria blooms, Harmful Algae, vol.8, issue.5, pp.715-740, 2009.
DOI : 10.1016/j.hal.2009.02.004

T. Davis, M. Harke, M. Marcoval, J. Goleski, C. Orano-dawson et al., Effects of nitrogenous compounds and phosphorus on the growth of toxic and non-toxic strains of Microcystis during cyanobacterial blooms, Aquatic Microbial Ecology, vol.61, issue.2, pp.149-162, 2010.
DOI : 10.3354/ame01445

D. Donald, M. Bogard, K. Finlay, and P. Leavitt, Comparative effects of urea, ammonium, and nitrate on phytoplankton abundance, community composition, and toxicity in hypereutrophic freshwaters, Limnology and Oceanography, vol.56, issue.6, pp.2161-75, 2011.
DOI : 10.4319/lo.2011.56.6.2161

C. Dziallas and H. Grossart, Increasing Oxygen Radicals and Water Temperature Select for Toxic Microcystis sp, PLoS ONE, vol.119, issue.725, p.25569, 2011.
DOI : 10.1371/journal.pone.0025569.s002

A. Eiler, C. Gonzalez-rey, S. Allen, and S. Bertilsson, Growth response of Vibrio cholerae and other Vibrio spp. to cyanobacterial dissolved organic matter and temperature in brackish water, FEMS Microbiology Ecology, vol.60, issue.3, pp.411-418, 2007.
DOI : 10.1111/j.1574-6941.2007.00303.x

G. Horst, O. Sarnelle, J. White, S. Hamilton, R. Kaul et al., Nitrogen availability increases the toxin quota of a harmful cyanobacterium, Microcystis aeruginosa, Water Research, vol.54, pp.188-98, 2014.
DOI : 10.1016/j.watres.2014.01.063

S. Jahnichen, T. Ihle, T. Petzoldt, and J. Benndorf, Impact of Inorganic Carbon Availability on Microcystin Production by Microcystis aeruginosa PCC 7806, Applied and Environmental Microbiology, vol.73, issue.21, pp.73-6994, 2007.
DOI : 10.1128/AEM.01253-07

D. Li, Y. Yu, Z. Yang, F. Kong, T. Zhang et al., The dynamics of toxic and nontoxic Microcystis during bloom in the large shallow lake, Lake Taihu, China, Environmental Monitoring and Assessment, vol.20, issue.1, pp.3053-62, 2014.
DOI : 10.1007/s10661-013-3600-x

B. Long, G. Jones, and P. Orr, Cellular Microcystin Content in N-Limited Microcystis aeruginosa Can Be Predicted from Growth Rate, Applied and Environmental Microbiology, vol.67, issue.1, pp.278-83, 2001.
DOI : 10.1128/AEM.67.1.278-283.2001

B. Neilan, L. Pearson, J. Muenchhoff, M. Moffitt, and E. Dittmann, Environmental conditions that influence toxin biosynthesis in cyanobacteria, Environmental Microbiology, vol.6, issue.5, pp.1239-1253, 2013.
DOI : 10.1111/j.1462-2920.2012.02729.x

H. Oh, S. Lee, M. Jang, and B. Yoon, Microcystin Production by Microcystis aeruginosa in a Phosphorus-Limited Chemostat, Applied and Environmental Microbiology, vol.66, issue.1, pp.176-185, 2000.
DOI : 10.1128/AEM.66.1.176-179.2000

J. Rapala and K. Sivonen, Assessment of Environmental Conditions That Favor Hepatotoxic and Neurotoxic Anabaena spp. Strains Cultured under Light Limitation at Different Temperatures, Microbial Ecology, vol.36, issue.2, pp.181-92, 1998.
DOI : 10.1007/s002489900105

J. Rapala, K. Sivonen, C. Lyra, and S. Niemela, Variation of microcystins, cyanobacterial hepatotoxins, in Anabaena spp. as a function of growth stimuli, Applied and environmental microbiology, vol.63, issue.6, pp.2206-2218, 1997.

D. Schatz, Y. Keren, A. Vardi, A. Sukenik, and S. Carmeli, Towards clarification of the biological role of microcystins, a family of cyanobacterial toxins, Environmental Microbiology, vol.47, issue.4, pp.965-970, 2007.
DOI : 10.1002/tox.10065

D. Tillett, E. Dittmann, M. Erhard, H. Von-dohren, T. Borner et al., Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide???polyketide synthetase system, Chemistry & Biology, vol.7, issue.10, pp.753-764, 2000.
DOI : 10.1016/S1074-5521(00)00021-1

L. Tonk, D. Van-de-waal, P. Slot, J. Huisman, H. Matthijs et al., Amino acid availability determines the ratio of microcystin variants in the cyanobacterium Planktothrix agardhii, FEMS Microbiology Ecology, vol.65, issue.3, pp.383-90, 2008.
DOI : 10.1111/j.1574-6941.2008.00541.x

J. Turner, B. Good, D. Cole, and E. Lipp, Plankton composition and environmental factors contribute to Vibrio seasonality, The ISME Journal, vol.29, issue.9, pp.1082-1092, 2009.
DOI : 10.1128/AEM.70.7.4103-4110.2004

D. Van-de-waal, J. Huisman, P. Visser, H. Matthijs, G. Ferreruela et al., Pulsed nitrogen supply induces dynamic changes in the amino acid composition and microcystin production of the harmful cyanobacterium Planktothrix agardhii, FEMS Microbiology Ecology, vol.74, issue.2, pp.430-438, 2010.
DOI : 10.1111/j.1574-6941.2010.00958.x

D. Van-de-waal, J. Verspagen, J. Finke, V. Vournazou, A. Immers et al., Reversal in competitive dominance of a toxic versus non-toxic cyanobacterium in response to rising CO2, The ISME Journal, vol.27, issue.9, pp.1438-1450, 2011.
DOI : 10.1016/j.jsb.2005.05.007

D. Van-de-waal, J. Verspagen, M. Lurling, E. Van-donk, P. Visser et al., The ecological stoichiometry of toxins produced by harmful cyanobacteria: an experimental test of the carbon-nutrient balance hypothesis, Ecology Letters, vol.69, issue.12, pp.12-1326, 2009.
DOI : 10.1111/j.1461-0248.2009.01383.x

L. Yu, F. Kong, X. Shi, Z. Yang, M. Zhang et al., Effects of elevated CO2 on dynamics of microcystin-producing and non-microcystin-producing strains during Microcystis blooms, Journal of Environmental Sciences, vol.27, pp.251-258, 2015.
DOI : 10.1016/j.jes.2014.05.047

Y. Zilliges, J. Kehr, S. Meissner, K. Ishida, S. Mikkat et al., The Cyanobacterial Hepatotoxin Microcystin Binds to Proteins and Increases the Fitness of Microcystis under Oxidative Stress Conditions, PLoS ONE, vol.29, issue.3, p.17615, 2011.
DOI : 10.1371/journal.pone.0017615.s005

J. Asselman, C. Janssen, G. Smagghe, D. Schamphelaere, and K. , Ecotoxicity of binary mixtures of Microcystis aeruginosa and insecticides to Daphnia pulex, Environmental Pollution, vol.188, pp.56-63
DOI : 10.1016/j.envpol.2014.01.018

K. Nováková, L. Bláha, and P. Babica, Tumor promoting effects of cyanobacterial extracts are potentiated by anthropogenic contaminants ??? Evidence from in vitro study, Chemosphere, vol.89, issue.1, pp.30-37
DOI : 10.1016/j.chemosphere.2012.04.008

S. Wang, D. Tian, and W. Zheng, 2013 Combined exposure to 3-chloro-4-dichloromethyl-5-hydroxy-2(5H)- furanone and microcystin-LR increases genotoxicity in Chinese hamster ovary cells through oxidative stress, Environmental Science and Technology, vol.47, pp.1678-1687

*. Methylamino-l-alanine-)-not-*-saxitoxin, *. Not-lyngbyatoxin, and . Not, (lipopolysaccharide OR LPS) AND cyanobacteria) NOT *aplysiatoxin* NOT (palytoxin OR PLTX OR ostreocin*) NOT *ciguatoxin*) OR AB (cyanotoxin* NOT microcystin* NOT nodularin* NOT cylindrospermopsin* NOT *anatoxin* NOT (BMAA OR beta-N- Methylamino-L-alanine) NOT *saxitoxin* NOT lyngbyatoxin* NOT ((lipopolysaccharide OR LPS) AND cyanobacteria) NOT *aplysiatoxin* NOT (palytoxin OR PLTX OR ostreocin*) NOT *ciguatoxin*) OR DE (cyanotoxin* NOT microcystin* NOT nodularin* NOT cylindrospermopsin* NOT *anatoxin* NOT (BMAA OR beta, alanine) NOT *saxitoxin* NOT lyngbyatoxin* NOT ((lipopolysaccharide OR LPS) AND cyanobacteria) NOT *aplysiatoxin* NOT (palytoxin OR PLTX OR ostreocin*) NOT *ciguatoxin*) )

. Methylamino-l-alanine, NOT *saxitoxin* NOT lyngbyatoxin* NOT ((lipopolysaccharide OR LPS) AND cyanobacteria) NOT *aplysiatoxin* NOT (palytoxin OR PLTX OR ostreocin*) NOT *ciguatoxin*) OR AB

. Methylamino-l-alanine, NOT *saxitoxin* NOT lyngbyatoxin* NOT ((lipopolysaccharide OR LPS) AND cyanobacteria) NOT *aplysiatoxin* NOT (palytoxin OR PLTX OR ostreocin*) NOT *ciguatoxin*) OR KW

. Methylamino-l-alanine, NOT *saxitoxin* NOT lyngbyatoxin* NOT ((lipopolysaccharide OR LPS) AND cyanobacteria) NOT *aplysiatoxin* NOT (palytoxin OR PLTX OR ostreocin*) NOT *ciguatoxin*) ) Number of records retrieved 12