T. Evans and N. Chapple, The animal health market, Nature Reviews Drug Discovery, vol.1, issue.12, pp.937-938, 2002.
DOI : 10.1038/nrd975

T. R. Shryock, Opinion: The future of anti-infective products in animal health, Nature Reviews Microbiology, vol.75, issue.5, pp.425-430, 2004.
DOI : 10.1081/ABIO-120005773

S. Andrée, W. Jira, K. Schwind, H. Wagner, and F. Schwägele, Chemical safety of meat and meat products, Meat Science, vol.86, issue.1, pp.38-48, 2010.
DOI : 10.1016/j.meatsci.2010.04.020

H. Ashwin, S. Stead, and M. Caldow, A rapid microbial inhibition-based screening strategy for fluoroquinolone and quinolone residues in foods of animal origin, Analytica Chimica Acta, vol.637, issue.1-2, pp.241-246, 2009.
DOI : 10.1016/j.aca.2008.08.038

A. Huet, C. Charlier, S. A. Tittlemier, G. Singh, S. Benrejeb et al., Simultaneous Determination of (Fluoro)quinolone Antibiotics in Kidney, Marine Products, Eggs, and Muscle by Enzyme-Linked Immunosorbent Assay (ELISA), Journal of Agricultural and Food Chemistry, vol.54, issue.8, pp.2822-2827, 2006.
DOI : 10.1021/jf052445i

S. A. Mcewen and P. J. Fedorka-cray, Antimicrobial Use and Resistance in Animals, Clinical Infectious Diseases, vol.34, issue.s3, pp.93-106, 2002.
DOI : 10.1086/340246

A. C. Tanner, J. F. Prescott, J. D. Baggot, and R. D. Walker, Antimicrobial drug use in poultry, Antimicrobial Therapy in Veterinary Medicine, pp.637-655, 2000.

S. Millet and L. Maertens, The European ban on antibiotic growth promoters in animal feed: From challenges to opportunities, The Veterinary Journal, vol.187, issue.2, pp.143-144, 2011.
DOI : 10.1016/j.tvjl.2010.05.001

F. Baquero, The 2010 Garrod Lecture: The dimensions of evolution in antibiotic resistance: ex unibus plurum et ex pluribus unum, Journal of Antimicrobial Chemotherapy, vol.66, issue.8, pp.1659-1672, 2011.
DOI : 10.1093/jac/dkr214

F. Baquero, Environmental stress and evolvability in microbial systems, Clinical Microbiology and Infection, vol.15, pp.5-10, 2009.
DOI : 10.1111/j.1469-0691.2008.02677.x

A. Bruno and V. C. Mackay, Antimicrobial resistance and the activities of the Codex Alimentarius Commission, Revue Scientifique et Technique de l'OIE, vol.31, issue.1, pp.317-323, 2012.
DOI : 10.20506/rst.31.1.2122

I. Phillips, M. Casewell, and T. Cox, Does the use of antibiotics in food animals pose a risk to human health? A critical review of published data, Journal of Antimicrobial Chemotherapy, vol.53, issue.1, pp.28-52, 2004.
DOI : 10.1093/jac/dkg483

F. Baquero, A. P. Tedim, and T. M. Coque, Antibiotic resistance shaping multi-level population biology of bacteria, Frontiers in Microbiology, vol.4, issue.15, 2013.
DOI : 10.3389/fmicb.2013.00015

M. Laanen, D. Persoons, and S. Ribbens, Relationship between biosecurity and production/antimicrobial treatment characteristics in pig herds, The Veterinary Journal, vol.198, issue.2, pp.508-512, 2013.
DOI : 10.1016/j.tvjl.2013.08.029

M. Martinez, J. Blondeau, and C. E. Cerniglia, Workshop report: The 2012 Antimicrobial Agents in Veterinary Medicine: exploring the consequences of antimicrobial drug use: a 3-D approach, Journal of Veterinary Pharmacology and Therapeutics, vol.334, issue.Suppl. 3, pp.1-16, 2014.
DOI : 10.1111/jvp.12104

M. P. Doyle, G. H. Loneragan, H. M. Scott, and R. S. Singer, Antimicrobial Resistance: Challenges and Perspectives, Comprehensive Reviews in Food Science and Food Safety, vol.45, issue.12, pp.234-248, 2013.
DOI : 10.1111/1541-4337.12008

G. Ronald and S. Daniel, Pharmacologic modeling, Development of Innovative Drugs via Modeling with MATLAB, pp.87-141, 2014.

P. Lees, F. S. Aliabadi, and P. L. Toutain, PK-PD modelling: an alternative to dose titration studies for antimicrobial drug dosage selection, Regulatory Affairs Journal, vol.15, pp.175-180, 2004.

J. D. Mitchell, Q. A. Mckellar, and D. J. Mckeever, Evaluation of antimicrobial activity against Mycoplasma mycoides subsp. mycoides Small Colony using an in vitro dynamic dilution pharmacokinetic/pharmacodynamic model, Journal of Medical Microbiology, vol.62, issue.Pt_1, pp.56-61, 2013.
DOI : 10.1099/jmm.0.045971-0

A. F. Mohamed, O. Cars, and L. E. Friberg, A pharmacokinetic/pharmacodynamic model developed for the effect of colistin on Pseudomonas aeruginosa in vitro with evaluation of population pharmacokinetic variability on simulated bacterial killing, Journal of Antimicrobial Chemotherapy, vol.69, issue.5, pp.1350-1361, 2014.
DOI : 10.1093/jac/dkt520

V. A. Bhattaram, C. Bonapace, and D. M. Chilukuri, Impact of Pharmacometric Reviews on New Drug Approval and Labeling Decisions???a Survey of 31 New Drug Applications Submitted Between 2005 and 2006, Clinical Pharmacology & Therapeutics, vol.22, issue.2, pp.213-221, 2005.
DOI : 10.1038/sj.clpt.6100051

R. L. Lalonde, K. G. Kowalski, and M. Hutmacher, Model-based Drug Development, Clinical Pharmacology & Therapeutics, vol.33, issue.1, pp.21-32, 2007.
DOI : 10.1038/sj.clpt.6100235

C. C. Peck and J. T. Cross, ???Getting the Dose Right???: Facts, a Blueprint, and Encouragements, Clinical Pharmacology & Therapeutics, vol.58, issue.1, pp.12-14, 2007.
DOI : 10.1038/sj.clpt.6100215

E. I. Nielsen, O. Cars, and L. E. Friberg, Pharmacokinetic/Pharmacodynamic (PK/PD) Indices of Antibiotics Predicted by a Semimechanistic PKPD Model: a Step toward Model-Based Dose Optimization, Antimicrobial Agents and Chemotherapy, vol.55, issue.10, pp.4619-4630, 2011.
DOI : 10.1128/AAC.00182-11

R. Miller, W. Ewy, and B. W. Corrigan, How Modeling and Simulation Have Enhanced Decision Making in New Drug Development, Journal of Pharmacokinetics and Pharmacodynamics, vol.73, issue.2, pp.185-197, 2005.
DOI : 10.1007/s10928-005-0074-7

S. Schmidt, A. Barbour, M. Sahre, K. H. Rand, and H. Derendorf, PK/PD: new insights for antibacterial and antiviral applications, Current Opinion in Pharmacology, vol.8, issue.5, pp.549-556, 2008.
DOI : 10.1016/j.coph.2008.06.010

G. L. Drusano, Antimicrobial pharmacodynamics: critical interactions of 'bug and drug', Nature Reviews Microbiology, vol.36, issue.4, pp.289-300, 2004.
DOI : 10.1016/S0924-8579(02)00031-6

B. Wu, S. K. Sy, H. Derendorf, S. Stephan, Z. Luning et al., Principles of applied pharmacokinetic?pharmacodynamic modeling Application of pharmacokinetic/pharmacodynamic modelling and simulation for the prediction of target attainment of ceftobiprole against methicillin-resistant Staphylococcus aureus using minimum inhibitory concentration and timekill curve based approaches, Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics, pp.63-79, 2014.

J. W. Mouton, M. N. Dudley, O. Cars, H. Derendorf, and G. L. Drusano, Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update, Journal of Antimicrobial Chemotherapy, vol.55, issue.5, pp.601-607, 2005.
DOI : 10.1093/jac/dki079

T. Potter, J. Illambas, L. Pelligand, A. Rycroft, and P. Lees, Erratum to 'pharmacokinetic and pharmacodynamic integration and modeling of marbofloxacin in calves for Mannheimia haemolytica and Pasteurella multocida' [The Veterinary Journal 195, The Veterinary Journal, vol.196, pp.53-58, 2013.

J. W. Mouton, D. F. Brown, and P. Apfalter, The role of pharmacokinetics/pharmacodynamics in setting clinical MIC breakpoints: the EUCAST approach, Clinical Microbiology and Infection, vol.18, issue.3, pp.37-45, 2012.
DOI : 10.1111/j.1469-0691.2011.03752.x

W. A. Craig, State???of???the???Art Clinical Article: Pharmacokinetic/Pharmacodynamic Parameters: Rationale for Antibacterial Dosing of Mice and Men, Clinical Infectious Diseases, vol.26, issue.1, pp.1-12, 1998.
DOI : 10.1086/516284

Q. A. Mckellar, S. F. Sanchez-bruni, and D. G. Jones, Pharmacokinetic/pharmacodynamic relationships of antimicrobial drugs used in veterinary medicine, Journal of Veterinary Pharmacology and Therapeutics, vol.58, issue.2, pp.503-514, 2004.
DOI : 10.1046/j.1365-2885.1999.00187.x

M. G. Papich, Pharmacokinetic???pharmacodynamic (PK???PD) modeling and the rational selection of dosage regimes for the prudent use of antimicrobial drugs, Veterinary Microbiology, vol.171, issue.3-4, pp.3-4, 2014.
DOI : 10.1016/j.vetmic.2013.12.021

P. G. Ambrose, S. M. Bhavnani, and C. M. Rubino, Antimicrobial Resistance: Pharmacokinetics???Pharmacodynamics of Antimicrobial Therapy: It???s Not Just for Mice Anymore, Clinical Infectious Diseases, vol.44, issue.1, pp.79-86, 2007.
DOI : 10.1086/510079

M. Siopi, E. Mavridou, J. W. Mouton, P. E. Verweij, L. Zerva et al., Susceptibility breakpoints and target values for therapeutic drug monitoring of voriconazole and Aspergillus fumigatus in an in vitro pharmacokinetic/pharmacodynamic model, Journal of Antimicrobial Chemotherapy, vol.69, issue.6, pp.1611-1619, 2014.
DOI : 10.1093/jac/dku023

M. R. Jacobs, Optimisation of antimicrobial therapy using pharmacokinetic and pharmacodynamic parameters, Clinical Microbiology and Infection, vol.7, issue.11, pp.589-596, 2001.
DOI : 10.1046/j.1198-743x.2001.00295.x

G. L. Drusano, Pharmacokinetics and Pharmacodynamics of Antimicrobials, Clinical Infectious Diseases, vol.45, issue.Supplement 1, pp.89-95, 2007.
DOI : 10.1086/518137

P. C. Taylor, F. D. Schoenknecht, J. C. Sherris, and E. C. Linner, Determination of minimum bactericidal concentrations of oxacillin for Staphylococcus aureus: influence and significance of technical factors., Antimicrobial Agents and Chemotherapy, vol.23, issue.1, pp.142-150, 1983.
DOI : 10.1128/AAC.23.1.142

T. Shimizu, K. Harada, and Y. Kataoka, Mutant prevention concentration of orbifloxacin: comparison between Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus pseudintermedius of canine origin, Acta Veterinaria Scandinavica, vol.55, issue.1, 2013.
DOI : 10.1093/jac/dkl135

A. Macgowan and K. Bowker, Developments in PK/PD: optimising efficacy and prevention of resistance. A critical review of PK/PD in in vitro models, International Journal of Antimicrobial Agents, vol.19, issue.4, pp.291-298, 2002.
DOI : 10.1016/S0924-8579(02)00027-4

J. Turnidge, Pharmacodynamics and dosing of aminoglycosides, Infectious Disease Clinics of North America, vol.17, issue.3, pp.503-528, 2003.
DOI : 10.1016/S0891-5520(03)00057-6

R. M. Balaje, P. K. Sidhu, G. Kaur, and S. , Mutant prevention concentration and PK???PD relationships of enrofloxacin for Pasteurella multocida in buffalo calves, Research in Veterinary Science, vol.95, issue.3, pp.1114-1124, 2013.
DOI : 10.1016/j.rvsc.2013.07.019

P. K. Sidhu, M. F. Landoni, F. S. Aliabadi, and P. Lees, Pharmacokinetic and pharmacodynamic modelling of marbofloxacin administered alone and in combination with tolfenamic acid in goats, The Veterinary Journal, vol.184, issue.2, pp.219-229, 2010.
DOI : 10.1016/j.tvjl.2009.02.009

F. S. Aliabadi and P. Lees, Pharmacokinetics and pharmacokinetic/pharmacodynamic integration of marbofloxacin in calf serum, exudate and transudate, Journal of Veterinary Pharmacology and Therapeutics, vol.18, issue.3, pp.161-174, 2002.
DOI : 10.1002/(SICI)1099-081X(199803)19:2<123::AID-BDD89>3.3.CO;2-7

A. Regnier, D. Concordet, M. Schneider, B. Boisrame, and P. Toutain, Population pharmacokinetics of marbofloxacin in aqueous humor after intravenous administration in dogs, American Journal of Veterinary Research, vol.64, issue.7, pp.889-893, 2003.
DOI : 10.2460/ajvr.2003.64.889

S. Waxman, M. D. San-andrés, F. González, J. J. De-lucas, M. I. San-andrés et al., Influence of Escherichia coli endotoxin-induced fever on the pharmacokinetic behavior of marbofloxacin after intravenous administration in goats, Journal of Veterinary Pharmacology and Therapeutics, vol.21, issue.1, pp.65-69, 2003.
DOI : 10.1046/j.1365-2885.2001.00357.x

M. Schneider, M. Vallé, F. Woehrlé, and B. Boisramé, Pharmacokinetics of Marbofloxacin in Lactating Cows After Repeated Intramuscular Administrations and Pharmacodynamics Against Mastitis Isolated Strains, Journal of Dairy Science, vol.87, issue.1, pp.202-211, 2004.
DOI : 10.3168/jds.S0022-0302(04)73159-8

W. A. Craig, Antimicrobial resistance issues of the future, Diagnostic Microbiology and Infectious Disease, vol.25, issue.4, pp.213-217, 1996.
DOI : 10.1016/S0732-8893(96)00162-9

W. A. Craig and D. Andes, Pharmacokinetics and pharmacodynamics of antibiotics in otitis media, The Pediatric Infectious Disease Journal, vol.15, issue.3, pp.255-259, 1996.
DOI : 10.1097/00006454-199603000-00015

W. A. Craig, The Pharmacology of Meropenem, A New Carbapenem Antibiotic, Clinical Infectious Diseases, vol.24, issue.Supplement 2, pp.266-275, 1997.
DOI : 10.1093/clinids/24.Supplement_2.S266

I. Ahmad, H. Hao, and L. Huang, Integration of PK/PD for dose optimization of Cefquinome against Staphylococcus aureus causing septicemia in cattle, Frontiers in Microbiology, vol.94, issue.588, 2015.
DOI : 10.3168/jds.2010-4109

W. Hengzhuang, H. Wu, O. Ciofu, Z. Song, and N. Høibya, In Vivo Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem in Pseudomonas aeruginosa Biofilm Infection, Antimicrobial Agents and Chemotherapy, vol.56, issue.5, pp.2683-2690, 2012.
DOI : 10.1128/AAC.06486-11

S. M. Paul, D. A. Michael, and E. B. Thomas, Antimicrobial drug use in veterinary medicine ACVIM consensus statement Use of Monte Carlo simulation to determine pharmacodynamic cutoffs of amoxicillin to establish a breakpoint for antimicrobial susceptibility testing in pigs, Journal of Veterinary Internal Medicine American Journal of Veterinary Research, vol.19, issue.75 2, pp.617-629, 2005.

P. L. Toutain, J. R. Castillo, and A. Bousquet-mélou, The pharmacokinetic???pharmacodynamic approach to a rational dosage regimen for antibiotics, Research in Veterinary Science, vol.73, issue.2, pp.105-114, 2002.
DOI : 10.1016/S0034-5288(02)00039-5

URL : https://hal.archives-ouvertes.fr/hal-00517583

F. S. Aliabadi and P. Lees, Pharmacokinetic???pharmacodynamic integration of danofloxacin in the calf, Research in Veterinary Science, vol.74, issue.3, pp.247-259, 2003.
DOI : 10.1016/S0034-5288(03)00005-5

J. D. Turnidge, The Pharmacodynamics of ?????Lactams, Clinical Infectious Diseases, vol.27, issue.1, pp.10-22, 1998.
DOI : 10.1086/514622

S. Corvaisier, P. H. Maire, M. Y. Bouvier-dyvoire, X. Barbaut, N. Bleyzac et al., Comparisons between antimicrobial pharmacodynamic indices and bacterial killing as described by using the Zhi model, Antimicrobial Agents and Chemotherapy, vol.42, issue.7, pp.1731-1737, 1998.

J. Zhi, C. H. Nightingale, and R. Quintiliani, Microbial pharmacodynamics of piperacillin in neutropenic mice of systematic infection due toPseudomonas aeruginosa, Journal of Pharmacokinetics and Biopharmaceutics, vol.6, issue.Suppl. 1, pp.355-375, 1988.
DOI : 10.1007/BF01062551

E. I. Nielsen and L. E. Friberg, Pharmacokinetic-Pharmacodynamic Modeling of Antibacterial Drugs, Pharmacological Reviews, vol.65, issue.3, pp.1053-1090, 2013.
DOI : 10.1124/pr.111.005769

M. V. Vasseur, M. Laurentie, and J. Rolland, Low or High Doses of Cefquinome Targeting Low or High Bacterial Inocula Cure Klebsiella pneumoniae Lung Infections but Differentially Impact the Levels of Antibiotic Resistance in Fecal Flora, Antimicrobial Agents and Chemotherapy, vol.58, issue.3, pp.1744-1748, 2014.
DOI : 10.1128/AAC.02135-13

URL : https://hal.archives-ouvertes.fr/hal-00978511

A. Ferran, V. Dupouy, P. Toutain, and A. Bousquet-mélou, Influence of Inoculum Size on the Selection of Resistant Mutants of Escherichia coli in Relation to Mutant Prevention Concentrations of Marbofloxacin, Antimicrobial Agents and Chemotherapy, vol.51, issue.11, pp.4163-4166, 2007.
DOI : 10.1128/AAC.00156-07

URL : https://hal.archives-ouvertes.fr/hal-00517559

A. S. Kesteman, A. A. Ferran, and A. Perrin-guyomard, Influence of inoculum size and dosing regimen on the selection of marbofloxacin resistant mutants in experimental rat Klebsiella pneumoniae lung infection, Journal of Veterinary Pharmacology and Therapeutics, vol.32, issue.1, p.63, 2009.

S. K. Olofsson and O. Cars, Optimizing Drug Exposure to Minimize Selection of Antibiotic Resistance, Clinical Infectious Diseases, vol.45, issue.Supplement 2, pp.129-136, 2007.
DOI : 10.1086/519256

P. A. Zur-wiesch, R. Kouyos, J. Engelstädter, R. R. Regoes, and S. Bonhoeffer, Population biological principles of drug-resistance evolution in infectious diseases, The Lancet Infectious Diseases, vol.11, issue.3, pp.236-247, 2011.
DOI : 10.1016/S1473-3099(10)70264-4

J. W. Mouton, P. G. Ambrose, and R. Canton, Conserving antibiotics for the future: New ways to use old and new drugs from a pharmacokinetic and pharmacodynamic perspective, Drug Resistance Updates, vol.14, issue.2, pp.107-117, 2011.
DOI : 10.1016/j.drup.2011.02.005

T. P. Lodise and J. Butterfield, Use of pharmacodynamic principles to inform ??-lactam dosing: ???S??? does not always mean success, Journal of Hospital Medicine, vol.6, issue.S1, pp.16-23, 2011.
DOI : 10.1002/jhm.869

S. H. Podolsky, Antibiotics and the Social History of the Controlled Clinical Trial, 1950-1970, Journal of the History of Medicine and Allied Sciences, vol.65, issue.3, pp.327-367, 1950.
DOI : 10.1093/jhmas/jrq003

A. Andremont, C. Brun-buisson, and M. Struelens, Evaluating and predicting the ecologic impact of antibiotics, Clinical Microbiology and Infection, vol.7, pp.1-6, 2001.
DOI : 10.1046/j.1469-0691.2001.00065.x

R. G. Finch, Antibiotic resistance, Journal of Antimicrobial Chemotherapy, vol.42, issue.2, pp.989-994, 2004.
DOI : 10.1093/jac/42.2.125

H. K. Allen, J. Donato, H. H. Wang, K. A. Cloud-hansen, J. Davies et al., Call of the wild: antibiotic resistance genes in natural environments, Nature Reviews Microbiology, vol.22, issue.4, pp.251-259, 2010.
DOI : 10.1038/nrmicro2312

R. C. Owens-jr and A. F. Shorr, Rational dosing of antimicrobial agents: Pharmacokinetic and pharmacodynamic strategies, American Journal of Health-System Pharmacy, vol.66, issue.12_Supplement_4, pp.23-30, 2009.
DOI : 10.2146/090087d

J. M. Blondeau, X. Zhao, G. Hansen, and K. Drlica, Mutant Prevention Concentrations of Fluoroquinolones for Clinical Isolates of Streptococcus pneumoniae, Antimicrobial Agents and Chemotherapy, vol.45, issue.2, pp.433-438, 2001.
DOI : 10.1128/AAC.45.2.433-438.2001

M. Vallé, M. Schneider, D. Galland, H. Giboin, and F. Woehrlé, Pharmacokinetic and pharmacodynamic testing of marbofloxacin administered as a single injection for the treatment of bovine respiratory disease, Journal of Veterinary Pharmacology and Therapeutics, vol.62, issue.6, pp.519-528, 2012.
DOI : 10.1111/j.1365-2885.2011.01350.x

G. L. Drusano, D. E. Johnson, M. Rosen, and H. C. Standiford, Pharmacodynamics of a fluoroquinolone antimicrobial agent in a neutropenic rat model of Pseudomonas sepsis., Antimicrobial Agents and Chemotherapy, vol.37, issue.3, pp.483-490, 1993.
DOI : 10.1128/AAC.37.3.483

N. Frimodt-møller, How predictive is PK/PD for antibacterial agents?, International Journal of Antimicrobial Agents, vol.19, issue.4, pp.333-339, 2002.
DOI : 10.1016/S0924-8579(02)00029-8

J. J. Schentag, Pharmacokinetic and pharmacodynamic predictors of antimicrobial efficacy: moxifloxacin and Streptococcus pneumoniae, Journal of Chemotherapy, vol.14, issue.2, pp.13-21, 2002.

M. E. Levison, Pharmacodynamics of antimicrobial drugs, Infectious Disease Clinics of North America, vol.18, issue.3, pp.451-465, 2004.
DOI : 10.1016/j.idc.2004.04.012

R. Wise, Maximizing efficacy and reducing the emergence of resistance, Journal of Antimicrobial Chemotherapy, vol.51, issue.90001, pp.37-42, 2003.
DOI : 10.1093/jac/dkg210

L. E. Stearne, W. H. Goessens, J. W. Mouton, and I. C. Gyssens, Effect of Dosing and Dosing Frequency on the Efficacy of Ceftizoxime and the Emergence of Ceftizoxime Resistance during the Early Development of Murine Abscesses Caused by Bacteroides fragilis and Enterobacter cloacae Mixed Infection, Antimicrobial Agents and Chemotherapy, vol.51, issue.10, pp.3605-3611, 2007.
DOI : 10.1128/AAC.01486-06

W. P. Caron and S. A. Mousa, Prevention strategies for antimicrobial resistance: a systematic review of the literature, Journal of Infection and Drug Resistance, vol.3, pp.25-33, 2010.

Y. Zhu, L. Hu, and Q. Mei, Testing the mutant selection window in rabbits infected with methicillin-resistant Staphylococcus aureus exposed to vancomycin, Journal of Antimicrobial Chemotherapy, vol.67, issue.11, pp.2700-2706, 2012.
DOI : 10.1093/jac/dks280

L. Xu, H. Wang, X. Yang, and L. Lu, Integrated pharmacokinetics/pharmacodynamics parameters-based dosing guidelines of enrofloxacin in grass carp Ctenopharyngodon idella to minimize selection of drug resistance, BMC Veterinary Research, vol.9, issue.1, 2013.
DOI : 10.1016/j.vetmic.2006.08.018

X. Zhao and K. Drlica, A unified anti-mutant dosing strategy, Journal of Antimicrobial Chemotherapy, vol.62, issue.3, pp.434-436, 2008.
DOI : 10.1093/jac/dkn229

C. Vilalta, H. Giboin, M. Schneider, F. E. Garch, and L. Fraile, infections in nursery and fattener pigs using Monte Carlo simulations, Journal of Veterinary Pharmacology and Therapeutics, vol.62, issue.6, pp.542-549, 2014.
DOI : 10.1111/jvp.12134

L. Opatowski, D. Guillemot, P. Boëlle, and L. Temime, Contribution of mathematical modeling to the fight against bacterial antibiotic resistance, Current Opinion in Infectious Diseases, vol.24, issue.3, pp.279-287, 2011.
DOI : 10.1097/QCO.0b013e3283462362

A. A. Ferran, D. Bibbal, and T. Pellet, Pharmacokinetic/pharmacodynamic assessment of the effects of parenteral administration of a fluoroquinolone on the intestinal microbiota: Comparison of bactericidal activity at the gut versus the systemic level in a pig model, International Journal of Antimicrobial Agents, vol.42, issue.5, pp.429-435, 2013.
DOI : 10.1016/j.ijantimicag.2013.07.008

URL : https://hal.archives-ouvertes.fr/hal-00875291

L. B. Sheiner and J. Steimer, Pharmacokinetic/Pharmacodynamic Modeling in Drug Development, Annual Review of Pharmacology and Toxicology, vol.40, issue.1, pp.67-95, 2000.
DOI : 10.1146/annurev.pharmtox.40.1.67

M. Müller, U. Müller-zellenberg, G. Hochhaus, and H. Derendorf, Current concepts in pharmacokinetics and their implications for clinical medicine, Wiener Klinische Wochenschrift, vol.113, pp.15-16, 2001.

J. Y. Chien, S. Friedrich, M. A. Heathman, D. P. De-alwis, and V. Sinha, Pharmacokinetics/pharmacodynamics and the stages of drug development: Role of modeling and simulation, The AAPS Journal, vol.7, issue.3, pp.544-559, 2005.
DOI : 10.1208/aapsj070355

T. Katsube, T. Wajima, Y. Yamano, and Y. Yano, Pharmacokinetic/Pharmacodynamic Modeling for Concentration-Dependent Bactericidal Activity of a Bicyclolide, Modithromycin, Journal of Pharmaceutical Sciences, vol.103, issue.4, pp.1288-1297, 2014.
DOI : 10.1002/jps.23897

B. W. Gunderson, G. H. Ross, K. H. Ibrahim, and J. C. Rotschafer, What Do We Really Know About Antibiotic Pharmacodynamics?, Pharmacotherapy, vol.43, issue.11 Part 2, pp.302-318, 2001.
DOI : 10.1159/000007198

P. D. Lister, The role of pharmacodynamic research in the assessment and development of new antibacterial drugs, Biochemical Pharmacology, vol.71, issue.7, pp.1057-1065, 2006.
DOI : 10.1016/j.bcp.2005.10.038

F. Baquero, V. F. Lanza, R. Cantón, and T. M. Coque, Public health evolutionary biology of antimicrobial resistance: priorities for intervention, Evolutionary Applications, vol.185, issue.Suppl, pp.223-239, 2014.
DOI : 10.1111/eva.12235