In vitro metabolism of the cyanotoxin cylindrospermopsin in HepaRG cells and liver tissue fractions - Archive ouverte HAL Access content directly
Journal Articles Toxicon Year : 2016

In vitro metabolism of the cyanotoxin cylindrospermopsin in HepaRG cells and liver tissue fractions

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Abstract

No evidence for phase I metabolites of the cyanotoxin cylindrospermopsin (CYN) was given using HepaRG cells and different liver tissue fractions when studying metabolic conversion. Although the application of ketoconazole, a CYP3A4 inhibitor, led to a decreased cytotoxicity of CYN, no metabolites were detected applying high resolution mass spectrometry. Quantification of non-modified CYN led to recovery rates of almost 100%. Consequently, reduction of CYN toxicity in the presence of metabolism inhibiting agents must be attributed to alternative pathways.
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anses-01346329 , version 1 (18-07-2016)

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K Kittler, Dominique Hurtaud Pessel, R Maul, F Kolrep, Valérie Fessard,. In vitro metabolism of the cyanotoxin cylindrospermopsin in HepaRG cells and liver tissue fractions. Toxicon, 2016, 110, pp.47-50. ⟨10.1016/j.toxicon.2015.11.007⟩. ⟨anses-01346329⟩

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