In vitro metabolism of the cyanotoxin cylindrospermopsin in HepaRG cells and liver tissue fractions

Abstract : No evidence for phase I metabolites of the cyanotoxin cylindrospermopsin (CYN) was given using HepaRG cells and different liver tissue fractions when studying metabolic conversion. Although the application of ketoconazole, a CYP3A4 inhibitor, led to a decreased cytotoxicity of CYN, no metabolites were detected applying high resolution mass spectrometry. Quantification of non-modified CYN led to recovery rates of almost 100%. Consequently, reduction of CYN toxicity in the presence of metabolism inhibiting agents must be attributed to alternative pathways.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-anses.archives-ouvertes.fr/anses-01346329
Contributeur : Emmanuelle Chiffoleau <>
Soumis le : lundi 18 juillet 2016 - 16:59:12
Dernière modification le : vendredi 3 août 2018 - 16:10:03

Identifiants

Collections

Citation

K Kittler, Dominique Hurtaud Pessel, R Maul, F Kolrep, Valérie Fessard,. In vitro metabolism of the cyanotoxin cylindrospermopsin in HepaRG cells and liver tissue fractions. Toxicon, Elsevier, 2016, 110, pp.47-50. 〈http://www.sciencedirect.com/science/article/pii/S0041010115301331〉. 〈10.1016/j.toxicon.2015.11.007〉. 〈anses-01346329〉

Partager

Métriques

Consultations de la notice

60