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Journal articles
In vitro metabolism of the cyanotoxin cylindrospermopsin in HepaRG cells and liver tissue fractions
Abstract : No evidence for phase I metabolites of the cyanotoxin cylindrospermopsin (CYN) was given using HepaRG cells and different liver tissue fractions when studying metabolic conversion. Although the application of ketoconazole, a CYP3A4 inhibitor, led to a decreased cytotoxicity of CYN, no metabolites were detected applying high resolution mass spectrometry. Quantification of non-modified CYN led to recovery rates of almost 100%. Consequently, reduction of CYN toxicity in the presence of metabolism inhibiting agents must be attributed to alternative pathways.
https://hal-anses.archives-ouvertes.fr/anses-01346329
Contributor : Emmanuelle Chiffoleau Connect in order to contact the contributor
Submitted on : Monday, July 18, 2016 - 4:59:12 PM
Last modification on : Wednesday, November 3, 2021 - 6:56:52 AM
Contributor : Emmanuelle Chiffoleau Connect in order to contact the contributor
Submitted on : Monday, July 18, 2016 - 4:59:12 PM
Last modification on : Wednesday, November 3, 2021 - 6:56:52 AM