Skip to Main content Skip to Navigation
Journal articles

Additive Value of Dynamic FDOPA PET/CT for Glioma Grading

Abstract : Purpose: The aim of this study was to assess the value of the FDOPA PET kinetic parameters extracted using full kinetic analysis for tumor grading with neuronavigation-guided biopsies as reference in patients with newly-diagnosed gliomas. Methods: Fourteen patients with untreated gliomas were investigated. Twenty minutes of dynamic positron-emission tomography (PET) imaging and a 20-min static image 10 min after injection were reconstructed from a 40-min list-mode acquisition immediately after FDOPA injection. Tumors volume-of-interest (VOI) were generated based on the MRI-guided brain biopsies. Static parameters (TBRmax and TBRmean) and kinetic parameters [K1 and k2 using full kinetic analysis with the reversible single-tissue compartment model with blood volume parameter and the time-to-peak (TTP)] were extracted. Performances of each parameter for differentiating low-grade gliomas (LGG) from high-grade gliomas (HGG) were evaluated by receiver-operating characteristic analyses (area under the curve; AUC). Results: Thirty-two tumoral VOI were analyzed. K1, k2, and TTP were significantly higher for HGG than for LGG (median K1-value = 0.124 vs. 0.074 ml/ccm/min, p = 0.025, median k2-value = 0.093 vs. 0.063 min(-1), p = 0.025, and median TTP-value = 10.0 vs. 15.0 min, p = 0.025). No significant difference was observed for the static parameters. The AUC for the kinetic parameters was higher than the AUC for the static parameters (respectively, AUC(K1) = 0.787, AUC(k2) = 0.785, AUC(TTP) = 0.775, AUC(TBRmax) = 0.551, AUC(TBRmean) = 0.575), significantly compared to TBRmax (respectively, p = 0.001 for K1, p = 0.031 for k2, and p = 0.029 for TTP). Conclusion: The present study suggests an additive value of FDOPA PET/CT kinetic parameters for newly-diagnosed gliomas grading.
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-03329582
Contributor : Admin HAL UR1 Connect in order to contact the contributor
Submitted on : Friday, May 6, 2022 - 2:18:44 PM
Last modification on : Friday, August 5, 2022 - 11:49:41 AM
Long-term archiving on: : Sunday, August 7, 2022 - 7:04:00 PM

File

pdf
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Antoine Girard, Pierre-Jean Le Reste, Alice Metais, Nibras Chaboub, Anne Devillers, et al.. Additive Value of Dynamic FDOPA PET/CT for Glioma Grading. Frontiers in Medicine, Frontiers media, 2021, 8, pp.705996. ⟨10.3389/fmed.2021.705996⟩. ⟨hal-03329582⟩

Share

Metrics

Record views

26

Files downloads

5